{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:14:17Z","timestamp":1777029257974,"version":"3.51.4"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"12","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpem-2020-0298_abs_001_w2aab3b7c36b1b6b1aab1c15b1Aa\"><jats:title>Objectives<\/jats:title><jats:p>In general population, there are three phases in the human growth curve: infancy, childhood and puberty, with different main factors involved in their regulation and mathematical models to fit them. Achondroplasia children experience a fast decreasing growth during infancy and an \u201cadolescent growth spurt\u201d; however, there are no longitudinal studies that cover the analysis of the whole post-natal growth. Here we analyse the whole growth curve from infancy to adulthood applying the JPA-2 mathematical model.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2020-0298_abs_002_w2aab3b7c36b1b6b1aab1c15b2Aa\"><jats:title>Methods<\/jats:title><jats:p>Twenty-seven patients, 17 girls and 10 boys with achondroplasia, who reached adult size, were included. Height growth data was collected from birth until adulthood. Individual growth curves were estimated by fitting the JPA-2 model to each individual\u2019s height for age data.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2020-0298_abs_003_w2aab3b7c36b1b6b1aab1c15b3Aa\"><jats:title>Results<\/jats:title><jats:p>Height growth velocity curves show that after a period of fast decreasing growth velocity since birth, with a mean of 9.7\u00a0cm\/year at 1 year old, the growth velocity is stable in late preschool years, with a mean of 4.2\u00a0cm\/year. In boys, age and peak height velocity in puberty were 13.75\u00a0years and 5.08\u00a0cm\/year and reach a mean adult height of 130.52\u00a0cm. In girls, the age and peak height velocity in puberty were 11.1\u00a0years and 4.32\u00a0cm\/year and reach a mean adult height of 119.2\u00a0cm.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpem-2020-0298_abs_004_w2aab3b7c36b1b6b1aab1c15b4Aa\"><jats:title>Conclusions<\/jats:title><jats:p>The study of individual growth curves in achondroplasia children by the JPA-2 model shows the three periods, infancy, childhood and puberty, with a similar shape but lesser in magnitude than general population.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpem-2020-0298","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:00:45Z","timestamp":1605600045000},"page":"1589-1595","source":"Crossref","is-referenced-by-count":14,"title":["Growth in achondroplasia, from birth to adulthood, analysed by the JPA-2 model"],"prefix":"10.1515","volume":"33","author":[{"given":"Mariana","family":"del Pino","sequence":"first","affiliation":[{"name":"Growth and Development , Garrahan Hospital , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Fano","sequence":"additional","affiliation":[{"name":"Growth and Development , Garrahan Hospital , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Adamo","sequence":"additional","affiliation":[{"name":"Growth and Development , Garrahan Hospital , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2023040101094788857_j_jpem-2020-0298_ref_001_w2aab3b7c36b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Horton, WA, Hall, JG, Hecht, JT. Achondroplasia. Lancet 2007;370:162\u201372. https:\/\/doi.org\/10.1016\/s0140-6736(07)61090-3.","DOI":"10.1016\/S0140-6736(07)61090-3"},{"key":"2023040101094788857_j_jpem-2020-0298_ref_002_w2aab3b7c36b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Shiang, R, Thompson, LM, Zhu, YZ, Church, DM, Fielder, TJ, Bocian, M, et al.. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, Achondroplasia. Cell 1994;78:335\u201342. https:\/\/doi.org\/10.1016\/0092-8674(94)90302-6.","DOI":"10.1016\/0092-8674(94)90302-6"},{"key":"2023040101094788857_j_jpem-2020-0298_ref_003_w2aab3b7c36b1b6b1ab2b2b3Aa","unstructured":"Bellus, GA, Hefferon, TW, Ortiz de Luna, RI, Hecht, JT, Horton, WA, Machado, M, et al.. Achondroplasia is defined by recurrent G380R mutations of FGFR3. Am J Hum Genet 1995;56:368\u201373."},{"key":"2023040101094788857_j_jpem-2020-0298_ref_004_w2aab3b7c36b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Karlberg, JA. 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