{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:09:41Z","timestamp":1787022581771,"version":"build-2736575974"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2020-0349_abs_001_w2aab3b7c29b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Prevalence of Maternal and congenital hypothyroidism is on the rise. To present the thyroid stimulating hormone screening results in babies born to hypothyroid mothers and assess the burden, aetiology of hypothyroidism in these babies<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0349_abs_003_w2aab3b7c29b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All antenatal mothers attending our hospital during the study period were enrolled into the study. Group I includes 249 term babies born to hypothyroid mothers and group II comprises 2154 newborns born to mothers who are euthyroid. Heel prick thyroid stimulating hormone was done for all newborns on day 3 for both groups. Confirmatory venous testing was done for all for babies in group I and screen positives belonging to group II. Evaluation and therapy done as per standard guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0349_abs_004_w2aab3b7c29b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thyroid stimulating hormone values in the two groups are presented. There was significant correlation between peak maternal thyroid stimulating hormone and neonatal day 3 heel prick in group I (r=0.7, P&lt;0.05). The prevalence of positive screening test in groups I and II was 3.8 and 1.03% (p&lt;0.05) whereas corresponding values for confirmed disease was 4.3 and 0.6%, respectively (p&lt;0.05). Aetiological evaluation revealed both transient hypothyroidism (33.3%) and permanent hypothyroidism (66.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0349_abs_005_w2aab3b7c29b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>4.3% of babies born to hypothyroid mothers develop congenital hypothyroidism; aetiology being both transient and permanent. A venous test by 3\u00a0weeks is helpful in these babies to improve case identification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2020-0349","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T18:41:19Z","timestamp":1602700879000},"page":"237-241","source":"Crossref","is-referenced-by-count":6,"title":["Impact of maternal thyroid disease on neonatal thyroid status"],"prefix":"10.1515","volume":"34","author":[{"given":"Lakshmi","family":"Venugopalan","sequence":"first","affiliation":[{"name":"Department of Neonatology , Mehta Multispeciality Hospitals India pvt Ltd. , Chetpet , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Rajan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , Mehta Multispeciality Hospitals India pvt Ltd. , Chetpet , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemchand. K.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and Diabetes , Mehta Multispeciality Hospitals India pvt Ltd. , Chetpet , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Sankaran","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , Mehta Multispeciality Hospitals India pvt Ltd. , Chetpet , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gnanabalan","family":"Murugesan","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Mehta Multispeciality Hospitals India pvt Ltd. , Chetpet , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmughasundaram","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Mehta Multispeciality Hospitals India pvt Ltd. , Chetpet , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"2023040100571185343_j_jpem-2020-0349_ref_001_w2aab3b7c29b1b6b1ab2b2b1Aa","unstructured":"Manglik, AK, Chatterjee, N, Ghosh, G. Umbilical cord blood TSH levels in term neonates: a screening tool for congenital hypothyroidism. Indian Pediatr 2005;42:1029\u201332."},{"key":"2023040100571185343_j_jpem-2020-0349_ref_002_w2aab3b7c29b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Sudha, RP, Shriram, M, Sujatha, J, Seshadri, S. Congenital hypothyroidism: recent Indian data. Indian J Endocrinol Metab 2015;19:436\u20137. https:\/\/doi.org\/10.4103\/2230-8210.152800.","DOI":"10.4103\/2230-8210.152800"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_003_w2aab3b7c29b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Kaur, G, Srivastav, J, Jain, S, Chawla, D, Chavan, BS, Atwal, R, et al. Preliminary report on neonatal screening for congenital hypothyroidism, congenital adrenal hyperplasia and glucose-6-phosphate dehydrogenase deficiency: a Chandigarh experience. Indian J Pediatr 2010;77:969\u201373. https:\/\/doi.org\/10.1007\/s12098-010-0150-x.","DOI":"10.1007\/s12098-010-0150-x"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_004_w2aab3b7c29b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Gopalakrishnan, V, Joshi, K,Phadke, S, Dabadghao, P, Agarwal, M, Das, V. Newborn screening for congenital hypothyroidism, galactosemia and biotinidase deficiency in Uttar Pradesh, India. Indian Pediatr 2014;51:701\u20135. https:\/\/doi.org\/10.1007\/s13312-014-0485-x.","DOI":"10.1007\/s13312-014-0485-x"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_005_w2aab3b7c29b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Sheetal, GL, Nidhish, PS, Mehaboob, AK, Lakshminarayana, R. Gopaliah. Effect of maternal and neonatal factors on cord blood thyroid stimulating hormone. Indian J Endocrinol Metab 2016;20:317\u201323. https:\/\/doi.org\/10.4103\/2230-8210.179998.","DOI":"10.4103\/2230-8210.179998"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_006_w2aab3b7c29b1b6b1ab2b2b6Aa","unstructured":"Sanghvi, U, Diwakar, KK. Universal screening for congenital hypothyroidism. Indian Pediatr 2008;45:331\u20132."},{"key":"2023040100571185343_j_jpem-2020-0349_ref_007_w2aab3b7c29b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Devi, AR, Naushad, SM. Newborn screening in India. Indian J Pediatr 2004;71:157\u201360. https:\/\/doi.org\/10.1007\/bf02723099.","DOI":"10.1007\/BF02723099"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_008_w2aab3b7c29b1b6b1ab2b2b8Aa","unstructured":"Lafranchi, S, Hypothyroidism. In: Behrman, RE, Kleigman, RM, Jenson, HB, editors. Nelson Textbook of Pediatrics, 17th ed. Philadelphia: Saunders: 2004:1872\u20139 pp."},{"key":"2023040100571185343_j_jpem-2020-0349_ref_009_w2aab3b7c29b1b6b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Rose, SR, Brown, RS, Foley, T, Kaplowitz, TP, Kaye, CI, Sundararjan, S, et al. Update of newborn screening and therapy for congenital hypothyroidism, Pediatrics 2006;117:2290\u2013303. https:\/\/doi.org\/10.1542\/peds.2006-0915.","DOI":"10.1542\/peds.2006-0915"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_010_w2aab3b7c29b1b6b1ab2b2c10Aa","doi-asserted-by":"crossref","unstructured":"L\u00e9ger, J, Olivieri, A, Donaldson, M, Torresani, T, Krude, H, Guy van, V, et al. ESPE guidelines on screening, diagnosis and management of congenital hypothyroidism 2014. J Clin Endocrinol Metab 2014;99:363\u201384. https:\/\/doi.org\/10.1210\/jc.2013-1891.","DOI":"10.1210\/jc.2013-1891"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_011_w2aab3b7c29b1b6b1ab2b2c11Aa","unstructured":"MurtyNabhi, V, Bhashyakarla, U. Prevalence of thyroid dysfunction among pregnant women in a rural teaching hospital in Telengana, south India. Scholars J Appl Med Sci 2014;2:2022\u20135."},{"key":"2023040100571185343_j_jpem-2020-0349_ref_012_w2aab3b7c29b1b6b1ab2b2c12Aa","doi-asserted-by":"crossref","unstructured":"Rajput, R, Goel, V, Smiti, N, Rajput, M, Seth, S. Prevalence of thyroid dysfunction among women during the first trimester of pregnancy at a tertiary care hospital in Haryana. Indian J Endocrinol Metab 2015;19:416\u20139. https:\/\/doi.org\/10.4103\/2230-8210.152791.","DOI":"10.4103\/2230-8210.152791"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_013_w2aab3b7c29b1b6b1ab2b2c13Aa","doi-asserted-by":"crossref","unstructured":"De Groot, L, Abalovich, M, Alexander, EK, Amino, N, Barbour, L ,et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline.J Clin Endocrinol Metab 2012;97:2543\u201365. https:\/\/doi.org\/10.1210\/jc.2011-2803.","DOI":"10.1210\/jc.2011-2803"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_014_w2aab3b7c29b1b6b1ab2b2c14Aa","doi-asserted-by":"crossref","unstructured":"Frinke, MJ, Van Eijsden, M, Loomans, EM, Vrijkorte, TG, Rotteveel, J. Maternal hypothyroxinemia in early pregnancy predicts reduced performance in reaction time tests in 5- to 6-year old offspring. J Clin Endocrinol Metab 2013;98:1417\u201326. https:\/\/doi.org\/10.1210\/jc.2012-3389.","DOI":"10.1210\/jc.2012-3389"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_015_w2aab3b7c29b1b6b1ab2b2c15Aa","doi-asserted-by":"crossref","unstructured":"Henriche, J, BongersSchokking, JJ, Schenk, JJ, Ghassabian, A, Schmidt, HG, Visser, TJ, et al. Maternal thyroid function during early pregnancy and cognitive functioning in childhood: the generation R study. J Clin Endocrinol Metab 2010;95:4227\u201334. https:\/\/doi.org\/10.1210\/jc.2010-0415.","DOI":"10.1210\/jc.2010-0415"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_016_w2aab3b7c29b1b6b1ab2b2c16Aa","doi-asserted-by":"crossref","unstructured":"Ganaie, MA, Charoo, BA, Sofi, RA, Ahmed, A, Bhat, JI. Maternal overt hypothyroidism and neuro behavioural outcome of neonates. A cohort study from iodine deficient areas of north India. Indian Pediatr;52:864\u20136. https:\/\/doi.org\/10.1007\/s13312-015-0733-8.","DOI":"10.1007\/s13312-015-0733-8"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_017_w2aab3b7c29b1b6b1ab2b2c17Aa","doi-asserted-by":"crossref","unstructured":"Montero, M, Collea, JV, Frasier, SD, Mestman, JH. Successful outcome of pregnancy in women with hypothyroidism. Ann Intern Med 1981;99:31\u20134. https:\/\/doi.org\/10.7326\/0003-4819-94-1-31.","DOI":"10.7326\/0003-4819-94-1-31"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_018_w2aab3b7c29b1b6b1ab2b2c18Aa","doi-asserted-by":"crossref","unstructured":"Dussault, JH, Letarte, J, Guyda, H, Laberge, C. Lack of influence of thyroid antibodies on thyroid function in newborn infant on a mass screening program for congenital hypothyroidism. J Pediatr 1980;96:385\u20139. https:\/\/doi.org\/10.1016\/s0022-3476(80)80677-9.","DOI":"10.1016\/S0022-3476(80)80677-9"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_019_w2aab3b7c29b1b6b1ab2b2c19Aa","doi-asserted-by":"crossref","unstructured":"Rovelli, R, Vigone, MC, Giovanettoni, C, Passoni, A, MainaL, Corrias, A. Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life. Ital J Pediatr 2010;36:24. https:\/\/doi.org\/10.1186\/1824-7288-36-24.","DOI":"10.1186\/1824-7288-36-24"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_020_w2aab3b7c29b1b6b1ab2b2c20Aa","doi-asserted-by":"crossref","unstructured":"Tamaki, H, Amino, N, Aozasa, M, Mori, M, Iwatani, Y. Effective method for prediction of transient hypothyroidism in neonates born to mothers with chronic thyroiditis. Am J Perinatol 1989;6:296\u2013303. https:\/\/doi.org\/10.1055\/s-2007-999597.","DOI":"10.1055\/s-2007-999597"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_021_w2aab3b7c29b1b6b1ab2b2c21Aa","doi-asserted-by":"crossref","unstructured":"Ozdemir, H, Akman, I, Coskun, S, Demirel, U, Turan, S, Bereket, A. Maternal thyroid dysfunction and neonatal thyroid problems. Internet J Endocrinol 2013;2013:6. Article ID 987843.","DOI":"10.1155\/2013\/987843"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_022_w2aab3b7c29b1b6b1ab2b2c22Aa","doi-asserted-by":"crossref","unstructured":"TembouryMolana, MC, Rivero Martin, MJ, De Juan Ruiz, J, Ares Segura, S. Maternal autoimmune thyroid disease: relevance for the newborn.Med Clin 2015;144:297\u2013303. https:\/\/doi.org\/10.1016\/j.medcli.2013.10.024.","DOI":"10.1016\/j.medcle.2013.10.002"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_023_w2aab3b7c29b1b6b1ab2b2c23Aa","doi-asserted-by":"crossref","unstructured":"Evans, S, Gregory, JW, Barton, J, Bidder, C, Gibbs, J, Pryce, R et al. Transient congenital hypothyroidism due to thyroid stimulating hormone receptor blocking antibodies. Ann Clin Biochem 2011;48:386\u201390. https:\/\/doi.org\/10.1258\/acb.2011.011007.","DOI":"10.1258\/acb.2011.011007"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_024_w2aab3b7c29b1b6b1ab2b2c24Aa","doi-asserted-by":"crossref","unstructured":"Karlsson, FA, Dahlberg, FA, Ritzen, EM.Thyroid blocking antibodies in thyroiditis. Acta Med Scand 1984;215:461\u20136. https:\/\/doi.org\/10.1111\/j.0954-6820.1984.tb17679.x.","DOI":"10.1111\/j.0954-6820.1984.tb17679.x"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_025_w2aab3b7c29b1b6b1ab2b2c25Aa","doi-asserted-by":"crossref","unstructured":"Blazer, S, Moreh-Waterman, Y, Miller-Lotan, R, Tamir, A, Hochberg, Z. Maternal hypothyroidism may affect fetal growth and neonatal thyroid function. Obstet Gynecol 2003;102:232\u201341. https:\/\/doi.org\/10.1016\/s0029-7844(03)00513-1.","DOI":"10.1097\/00006250-200308000-00007"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_026_w2aab3b7c29b1b6b1ab2b2c26Aa","doi-asserted-by":"crossref","unstructured":"Brown, RS, Bellisario, RL, Botero, D, Fournier, L, Abrams, CA, Cowger, ML et al. Incidence of transient congenital hypothyroidism due to maternal thyrotropin receptor antibodies in over a million babies. J Clin Endocrinol Metab 1996;81:1147\u201351. https:\/\/doi.org\/10.1210\/jc.81.3.1147.","DOI":"10.1210\/jcem.81.3.8772590"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_027_w2aab3b7c29b1b6b1ab2b2c27Aa","unstructured":"Gassner, D, Golfer, R, Stock, W, Yoshimra, NJ, Sander, J, Ras Smith, B. Development of a new automated assay for thyrotropin receptor antibodies on elecyes system. Clin Chem 2007;53:C\u2013135."},{"key":"2023040100571185343_j_jpem-2020-0349_ref_028_w2aab3b7c29b1b6b1ab2b2c28Aa","doi-asserted-by":"crossref","unstructured":"Illiciki, A, Larsson, A, Karlsson, FA. Circulating thyroid antibodies in congenital hypothyroidism. ActaPediatr Scand 1991;80:805\u201311.","DOI":"10.1111\/j.1651-2227.1991.tb11953.x"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_029_w2aab3b7c29b1b6b1ab2b2c29Aa","doi-asserted-by":"crossref","unstructured":"Kim, H, Jung, YH, Choi, CW, Chung, HR, Kang, MJ, Kim, BI.. Thyroid dysfunction in preterm infants born before 32 gestational weeks. BMC Pediatr 2019;19:391. https:\/\/doi.org\/10.1186\/s12887-019-1792-0.","DOI":"10.1186\/s12887-019-1792-0"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_030_w2aab3b7c29b1b6b1ab2b2c30Aa","doi-asserted-by":"crossref","unstructured":"Yoon, SA, Chang, YS, Ahn, SY, In Sung, S, Park, WS. Initial and delayed thyroid-stimulating hormone elevation in extremely low-birth-weight infants. BMC Pediatr 2019;19:347. https:\/\/doi.org\/10.1186\/s12887-019-1730-1.","DOI":"10.1186\/s12887-019-1730-1"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_031_w2aab3b7c29b1b6b1ab2b2c31Aa","doi-asserted-by":"crossref","unstructured":"Korkmaz, G, \u00d6z\u00e7etin, M, \u00c7a\u011f, Y, Y\u00fckselmi\u015f, U, \u00d6ngel, V, I\u015f\u0131k, O. Thyroid function in healthy and unhealthy preterm newborns. Afr Health Sci 2018;18:378\u201383. https:\/\/doi.org\/10.4314\/ahs.v18i2.23.","DOI":"10.4314\/ahs.v18i2.23"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_032_w2aab3b7c29b1b6b1ab2b2c32Aa","doi-asserted-by":"crossref","unstructured":"Desai, MP, Sharma, R, Riaz, I, Sudhanshu, S, Parikh, R, Bhatia, V. Newborn screening guidelines for congenital hypothyroidism in India: recommendations of the Indian society for pediatric and adolescent endocrinology (ISPAE)\u00a0\u2013 part I: screening and confirmation of diagnosis. Indian J Pediatr 2018;85:440\u20137. https:\/\/doi.org\/10.1007\/s12098-017-2575-y.","DOI":"10.1007\/s12098-017-2575-y"},{"key":"2023040100571185343_j_jpem-2020-0349_ref_033_w2aab3b7c29b1b6b1ab2b2c33Aa","doi-asserted-by":"crossref","unstructured":"Sudhanshu, S, Riaz, I, Sharma, R, Desai, MP, Bhatia, V. Newborn screening guidelines for congenital hypothyroidism in India: recommendations of the Indian society for pediatric and adolescent endocrinology (ISPAE)\u00a0\u2013 part II: imaging, treatment and follow-up. Indian J Pediatr 2018;85:448\u201353. https:\/\/doi.org\/10.1007\/s12098-017-2576-x.","DOI":"10.1007\/s12098-017-2576-x"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpem\/ahead-of-print\/article-10.1515-jpem-2020-0349\/article-10.1515-jpem-2020-0349.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0349\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0349\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T13:28:12Z","timestamp":1680355692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0349\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,12,14]]},"published-print":{"date-parts":[[2021,2,23]]}},"alternative-id":["10.1515\/jpem-2020-0349"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2020-0349","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,13]]}}}