{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:12:24Z","timestamp":1775815944519,"version":"3.50.1"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"DOI":"10.13039\/501100001843","name":"Scientific and Engineering Research Board","doi-asserted-by":"crossref","award":["Grant# SB\/SO\/HS\/041\/2013"],"award-info":[{"award-number":["Grant# SB\/SO\/HS\/041\/2013"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0354_abs_001_w2aab3b7c43b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Pediatric pheochromocytoma and paraganglioma (PPGL) are rare tumors with limited data on the diagnostic performance of <jats:sup>68<\/jats:sup>Ga-DOTA(0)-Tyr(3)-octreotate positron emission tomography\u2013computed tomography (<jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT). We have described our experience of <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT in overall and von Hippel Lindau (VHL)-associated pediatric PPGL and compared its sensitivity with that of <jats:sup>131<\/jats:sup>I-meta-iodobenzyl-guanidine (<jats:sup>131<\/jats:sup>I-MIBG), <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose PET\/CT (<jats:sup>18<\/jats:sup>F-FDG PET\/CT), and contrast-enhanced CT (CECT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0354_abs_002_w2aab3b7c43b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective evaluation of consecutive PPGL patients (age:\u00a0\u226420 years), who had undergone at least one functional imaging [<jats:sup>131<\/jats:sup>I-MIBG, <jats:sup>18<\/jats:sup>F-FDG PET\/CT, and\/or <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT], was done. Composite of anatomical and all the performed functional imaging scans, image comparator (IC), was considered as the gold standard for sensitivity analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0354_abs_003_w2aab3b7c43b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In a cohort of 32 patients (16 males, age at diagnosis: 16.4\u00a0\u00b1\u00a02.68 years), lesion-wise sensitivity of <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT (95%) was higher than that of both\u00a0<jats:sup>18<\/jats:sup>F-FDG-PET\/CT (80%, p=0.027) and <jats:sup>131<\/jats:sup>I-MIBG (65%, p=0.0004) for overall lesions, than that of <jats:sup>18<\/jats:sup>F-FDG-PET\/CT (100 vs. 67%, p=0.017) for primary PPG, and than that of <jats:sup>131<\/jats:sup>I-MIBG (93 vs. 42%, p=0.0001) for metastases. In the\u00a0VHL (n=14), subgroup, <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT had\u00a0higher lesion-wise sensitivity (100%) compared to <jats:sup>18<\/jats:sup>F-FDG PET\/CT (74%, p=0.045) and <jats:sup>131<\/jats:sup>I-MIBG (64%, p=0.0145).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0354_abs_004_w2aab3b7c43b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our pediatric PPGL cohort, overall lesion-wise sensitivity of <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT was higher than that of <jats:sup>18<\/jats:sup>F\u2013FDG PET\/CT and <jats:sup>131<\/jats:sup>I-MIBG scintigraphy. Hence, we recommend <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT as the preferred modality in pediatric PPGL. <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT may evolve as a preferred imaging modality for disease surveillance in VHL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0354","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:10:08Z","timestamp":1605600608000},"page":"109-119","source":"Crossref","is-referenced-by-count":16,"title":["The utility of <sup>68<\/sup>Ga-DOTATATE PET\/CT in localizing primary\/metastatic pheochromocytoma and paraganglioma in children and adolescents\u00a0\u2013 a single-center experience"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-9251","authenticated-orcid":false,"given":"Sanjeet Kumar","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Endocrinology , Seth G.S. Medical College & KEM Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Sarathi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Vydehi Institute of Medical Sciences and Research Center , Bengaluru , Karnataka , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine , Bhabha Atomic Research Centre , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Hira","sequence":"additional","affiliation":[{"name":"Department of Radiology , Seth G.S. Medical College & KEM Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravikumar","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth G.S. Medical College & KEM Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virendra A.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth G.S. Medical College & KEM Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"Dalvi","sequence":"additional","affiliation":[{"name":"Department of General Surgery , Seth G.S. Medical College & KEM Hospital , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gagan","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Uro-Oncology , Tata Memorial Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag R.","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth G.S. Medical College & KEM Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalini S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth G.S. Medical College & KEM Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-4639","authenticated-orcid":false,"given":"Tushar","family":"Bandgar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth G.S. Medical College & KEM Hospital , Mumbai , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2023040101232108966_j_jpem-2020-0354_ref_001_w2aab3b7c43b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Wyszy\u0144ska, T, Cichocka, E, Wieteska\u2010Klimczak, A, Jobs, K, Januszewicz, P. 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