{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:11:20Z","timestamp":1790475080875,"version":"4.1.0"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0359_abs_001_w2aab3b7b4b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Familial hyperphosphatemic tumoral calcinosis is a rare disorder characterized by hyperphosphatemia with recurrent ectopic periarticular calcifications, in addition to other visceral and vascular manifestations, without any inflammatory or neoplastic disorder. The available treatment strategies are limited. Here we report an eight year old female patient with recurrent lesions under the chin, and bilateral hips which are painful and improving of the size of the lesions and hyperphosphatemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0359_abs_002_w2aab3b7b4b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>The patient was started to the treatment with peroral acetazolamide however the lesion did not regress but a new lesion appeared then we added sevelamer and topical sodium thiosulfate treatment for three months. After the three months of the combination treatment the lesions, there were no pain, no hyperphospahtemia regression\/disappearance of the lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0359_abs_003_w2aab3b7b4b1b6b1aab1c16b3Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This combination treatment or topical sodium thiosulfate use only may be a novel treatment strategy for the patients prospective controlled trials are needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0359","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T20:02:16Z","timestamp":1617652936000},"page":"813-816","source":"Crossref","is-referenced-by-count":7,"title":["Familial hyperphosphatemic tumoral calcinosis in an unusual and usual sites and dramatic improvement with the treatment of acetazolamide, sevelamer and topical sodium thiosulfate"],"prefix":"10.1515","volume":"34","author":[{"given":"Merve","family":"Emecen Sanli","sequence":"first","affiliation":[{"name":"Department of Inborn Errors of Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Inborn Errors of Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekin","family":"Aktasoglu","sequence":"additional","affiliation":[{"name":"Department of Inborn Errors of Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-2060","authenticated-orcid":false,"given":"Asli","family":"Inci","sequence":"additional","affiliation":[{"name":"Department of Inborn Errors of Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Okur","sequence":"additional","affiliation":[{"name":"Department of Inborn Errors of Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Ezgu","sequence":"additional","affiliation":[{"name":"Department of Inborn Errors of Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Tumer","sequence":"additional","affiliation":[{"name":"Department of Inborn Errors of Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"2023040101193746312_j_jpem-2020-0359_ref_001_w2aab3b7b4b1b6b1ab2b1b1Aa","unstructured":"Giard, A. 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