{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:29Z","timestamp":1747198229110,"version":"3.40.5"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"7","funder":[{"name":"Instituto Nacional de Pediatr\u00eda"},{"name":"CONACyT FOSISS","award":["272641"],"award-info":[{"award-number":["272641"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0378_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Cryptorchidism is the most common genitourinary birth defect in live newborn males and is considered as an important risk factor for testicular germ cell tumors and infertility. The Androgen Receptor gene is important in this pathology due to its participation, mainly, in the inguinoscrotal phase of testicular descent. We determine the length of the CAG tract in the Androgen Receptor (<jats:italic>AR<\/jats:italic>) gene in Mexican patients with nonsyndromic cryptorchidism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0378_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred and 15 males were included; of these, 62 had nonsyndromic cryptorchidism and 53 were healthy volunteers. DNA was extracted from a peripheral blood samples, subsequently, the CAG tract in exon 1 of <jats:italic>AR<\/jats:italic> gene was amplified by PCR and sequenced.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0378_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mexican patients with nonsyndromic cryptorchidism presented 25.03\u00a0\u00b1\u00a02.58 repeats of CAG tract in the <jats:italic>AR<\/jats:italic> gene compared to 22.72\u00a0\u00b1\u00a03.17 repeats of CAG tract in Mexican healthy individuals (p\u22640.0001; <jats:italic>t<\/jats:italic> value of 4.3). Furthermore, the deletion of codon 57 that corresponds to the deletion of a leucine residue at position 57 (Del L57) in the <jats:italic>AR<\/jats:italic> gene was found for the first time in a nonsyndromic cryptorchidism patient. This molecular alteration has been related previously to testicular germ cell tumor (TGCT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0378_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The CAG tract in the <jats:italic>AR<\/jats:italic> gene is longer in patients with nonsyndromic cryptorchidism than in healthy individuals, supporting the association between this polymorphism of the <jats:italic>AR<\/jats:italic> gene and nonsyndromic cryptorchidism in the Mexican population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0378","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T20:04:17Z","timestamp":1618085057000},"page":"843-849","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of the CAG tract length in the Androgen Receptor gene in Mexican patients with nonsyndromic cryptorchidism"],"prefix":"10.1515","volume":"34","author":[{"given":"Daniel A.","family":"Landero-Huerta","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda , Ciudad de M\u00e9xico , M\u00e9xico"},{"name":"Posgrado en Ciencias Naturales e Ingenier\u00eda, Universidad Aut\u00f3noma Metropolitana, Unidad Cuajimalpa , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa M.","family":"Vigueras-Villase\u00f1or","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Taja-Chayeb","sequence":"additional","affiliation":[{"name":"Laboratorio de Epigen\u00e9tica, Instituto Nacional de Cancerolog\u00eda , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Garc\u00eda-Andrade","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ar\u00e9chaga-Ocampo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales , Universidad Aut\u00f3noma Metropolitana, Unidad Cuajimalpa , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiy","family":"Yokoyama-Rebollar","sequence":"additional","affiliation":[{"name":"Departmento de Gen\u00e9tica Humana , Instituto Nacional de Pediatr\u00eda , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"D\u00edaz-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerolog\u00eda Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica en C\u00e1ncer, Instituto Nacional de Cancerolog\u00eda-Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Ciudad de M\u00e9xico , M\u00e9xico"},{"name":"Instituto Nacional de Medicina Gen\u00f3mica , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-0296","authenticated-orcid":false,"given":"Margarita D.","family":"Ch\u00e1vez-Salda\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda , Ciudad de M\u00e9xico , M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"2023040101233476431_j_jpem-2020-0378_ref_001","doi-asserted-by":"crossref","unstructured":"Sinopidis, X, Mourelatou, R, Kostopoulou, E, Karvela, A, Rojas-Gil, A, Tsekoura, E, et al.. 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