{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:12:17Z","timestamp":1776355937908,"version":"3.51.2"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0386_abs_001_w2aab3b7c62b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Treatment of central precocious puberty (CPP) is based on administration of GnRH agonists in order to suppress hypothalamic-pituitary-gonadal axis and thus induce the stabilization or regression of pubertal development. Our aim was to determine whether the single basal serum LH and\/or FSH concentration could be an effective tool to assess the efficacy of treatment to suppress activation of hypothalamic-pituitary axis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0386_abs_002_w2aab3b7c62b1b6b1aab1c15b2Aa\">\n                  <jats:title>Patients and methods<\/jats:title>\n                  <jats:p>Serum LH and FSH were measured before and after the GnRH injection, as well as E2 basal levels in 60 girls with documented idiopathic CPP at diagnosis and 18 and 30 months after the beginning of therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0386_abs_003_w2aab3b7c62b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At diagnosis, peaks of &gt;5\u00a0IU\/L of LH and of FSH were observed in 100 and 91.6% of girls, respectively, with basal LH values of &lt;1\u00a0IU\/L in 70% and basal FSH levels of &lt;1\u00a0IU\/L in 10%. E2 were &lt;20\u00a0pg\/mL in 36.6%. After 18 months, a suppressed peak (i.e. &lt;3\u00a0IU\/L) was recorded in 85% of girls (p&lt;0.01) for LH and in 98.3% for FSH (p&lt;0.01). Basal LH &lt;1\u00a0IU\/L was detected in 85% (p&lt;0.01) and basal FSH \u22641\u00a0IU\/L in 40% (p&lt;0.01). Serum E2 \u226420\u00a0pg\/mL was recorded in 61.6% (p&lt;0.01). After 30 months, all patients showed LH suppressed peak (p&lt;0.01) and 98.3% suppressed FSH peak (p&lt;0.01). 100% showed basal LH concentrations &lt;1\u00a0IU\/L (p&lt;0.01) and 38.3% FSH basal values &lt;1\u00a0UI\/mL (p&lt;0.01). E2 \u226420\u00a0pg\/mL was observed in 32.72% (p=NS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0386_abs_004_w2aab3b7c62b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Basal LH values are a reliable indicator of the efficacy of GnRHa therapy after 30 months of GnRHa therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0386","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T07:57:24Z","timestamp":1605599844000},"page":"45-50","source":"Crossref","is-referenced-by-count":12,"title":["Effectiveness of basal LH in monitoring central precocious puberty treatment in girls"],"prefix":"10.1515","volume":"34","author":[{"given":"Valeria","family":"Calcaterra","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Pediatrics and Adolescent Unit , University of Pavia , Pavia , Italy"},{"name":"Department of Pediatrics , Children's Hospital \u201cV. Buzzi\u201d , Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Service d\u2019Endocrinologie et Diab\u00e9tologie P\u00e9diatrique, H\u00f4pital Robert-Debr\u00e9 , Paris , France"},{"name":"French Clinical Research Group in Adolescent Medicine and Health , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Albertini","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry , Foundation IRCCS San Matteo , Pavia , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Rendina","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery , Federico II University , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Messini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hospital \u201cSan Giovanni Battista\u201d , Foligno , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Maria","family":"Monti","sequence":"additional","affiliation":[{"name":"Adolfo Ferrata Medical Library , University of Pavia , Pavia , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bozzola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Unit of Pediatrics and Infectious Diseases , Bambino Ges\u00f9 Children Hospital IRCCS , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Villani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Unit of Pediatrics and Infectious Diseases , Bambino Ges\u00f9 Children Hospital IRCCS , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Bozzola","sequence":"additional","affiliation":[{"name":"University of Pavia , Pavia , Italy"},{"name":"Onlus Il bambino e il suo pediatra , Novara , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2023040101232134893_j_jpem-2020-0386_ref_001_w2aab3b7c62b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Carel, JC, L\u00e9ger, J. 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