{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:29:51Z","timestamp":1793424591218,"version":"4.5.0"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0393_abs_001_w2aab3b7c36b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The purpose of this study was to evaluate the impact of recombinant human growth hormone (rhGH) on the development and progression of scoliosis in patients with idiopathic short stature (ISS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0393_abs_002_w2aab3b7c36b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with ISS who underwent rhGH treatment from 1997 to 2017 and were followed up for scoliosis screening with serial radiographic examination were included. For assessing scoliosis development, patients who did not have scoliosis at the time of rhGH treatment were included and followed up to determine whether <jats:italic>de novo<\/jats:italic> scoliosis developed during the treatment. For evaluating scoliosis progression, patients who already had scoliosis were analyzed. Univariate and multivariate Cox regression analyses of demographic and radiographic variables were performed to determine the related factors in the development and progression of scoliosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0393_abs_003_w2aab3b7c36b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For assessing scoliosis development, 1093 patients were included. The average duration of rhGH treatment was about 2 years. De novo scoliosis developed in 32 patients (3.7%). The analysis revealed that sex (p=0.016) and chronological age (p=0.048) were statistically significant factors associated with scoliosis development. However, no relationship was observed between scoliosis development and rhGH treatment types or duration. Among 67 patients who already had scoliosis at the time of rhGH treatment, 11 (16.4%) showed scoliosis progression. However, the rhGH types and duration also did not affect scoliosis progression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0393_abs_004_w2aab3b7c36b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>De novo scoliosis developed in 3.7% and scoliosis progressed in 16.4% of the patients during rhGH treatment. However, scoliosis development or progression was not affected by the types or duration of rhGH treatment in patients with ISS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0393","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:01:44Z","timestamp":1605600104000},"page":"243-250","source":"Crossref","is-referenced-by-count":18,"title":["Impact of growth hormone treatment on scoliosis development and progression: analysis of 1128 patients with idiopathic short stature"],"prefix":"10.1515","volume":"34","author":[{"given":"Se-Jun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Spine Center, Samsung Medical Center , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, College of Medicine , Hallym University, Kangdong Sacred Heart Hospital , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Suh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Spine Center, Samsung Medical Center , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Tack","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, College of Medicine , Kyung Hee University Hospital at Gangdong, Kyung Hee University , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hyuk","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, College of Medicine , Hallym University, Kangdong Sacred Heart Hospital , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, College of Medicine , Hallym University, Kangdong Sacred Heart Hospital , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Kyu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"2023040100571175878_j_jpem-2020-0393_ref_001_w2aab3b7c36b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Cheng, JC, Castelein, RM, Chu, WC, Danielsson, AJ, Dobbs, MB, Grivas, TB, et al.. Adolescent idiopathic scoliosis. Nat Rev Dis Primers 2015;1:15030. https:\/\/doi.org\/10.1038\/nrdp.2015.68.","DOI":"10.1038\/nrdp.2015.68"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_002_w2aab3b7c36b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Kikanloo, SR, Tarpada, SP, Cho, W. Etiology of adolescent idiopathic scoliosis: a literature review. Asian Spine J 2019;13:519\u201326. https:\/\/doi.org\/10.31616\/asj.2018.0096.","DOI":"10.31616\/asj.2018.0096"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_003_w2aab3b7c36b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Ng, S-Y, Bettany-Saltikov, J, Cheung, IYK, Chan, KKY. The role of vitamin D in the pathogenesis of adolescent idiopathic scoliosis. Asian Spine J 2018;12:1127. https:\/\/doi.org\/10.31616\/asj.2018.12.6.1127.","DOI":"10.31616\/asj.2018.12.6.1127"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_004_w2aab3b7c36b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Dimeglio, A, Canavese, F. Progression or not progression? How to deal with adolescent idiopathic scoliosis during puberty. J Child Orthop 2013;7:43\u20139. https:\/\/doi.org\/10.1007\/s11832-012-0463-6.","DOI":"10.1007\/s11832-012-0463-6"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_005_w2aab3b7c36b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Negrini, S, Donzelli, S, Aulisa, AG, Czaprowski, D, Schreiber, S, de Mauroy, JC, et al.. SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. Scolios Spinal Disord 2016;13:3, 2018.","DOI":"10.1186\/s13013-017-0145-8"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_006_w2aab3b7c36b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Bell, J, Parker, KL, Swinford, RD, Hoffman, AR, Maneatis, T, Lippe, B. Long-term safety of recombinant human growth hormone in children. J Clin Endocrinol Metab 2010;95:167\u201377. https:\/\/doi.org\/10.1210\/jc.2009-0178.","DOI":"10.1210\/jc.2009-0178"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_007_w2aab3b7c36b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Fong, DY, Lee, CF, Cheung, KM, Cheng, JC, Ng, BK, Lam, TP, et al.. A meta-analysis of the clinical effectiveness of school scoliosis screening. Spine Phila Pa 1976;35:1061\u201371, 2010.","DOI":"10.1097\/BRS.0b013e3181bcc835"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_008_w2aab3b7c36b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Grimberg, A, DiVall, SA, Polychronakos, C, Allen, DB, Cohen, LE, Quintos, JB, et al.. Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency. Horm Res Paediatr 2016;86:361\u201397. https:\/\/doi.org\/10.1159\/000452150.","DOI":"10.1159\/000452150"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_009_w2aab3b7c36b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Sitoula, P, Verma, K, Holmes, LJr., Gabos, PG, Sanders, JO, Yorgova, P, et al.. Prediction of curve progression in idiopathic scoliosis: validation of the sanders skeletal maturity staging system. Spine Phila Pa 1976;40:1006\u201313, 2015.","DOI":"10.1097\/BRS.0000000000000952"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_010_w2aab3b7c36b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Allen, DB. Safety of growth hormone treatment of children with idiopathic short stature: the US experience. Horm Res Paediatr 2011;76(3 Suppl):45\u20137. https:\/\/doi.org\/10.1159\/000330159.","DOI":"10.1159\/000330159"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_011_w2aab3b7c36b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Wang, ED, Drummond, DS, Dormans, JP, Moshang, T, Davidson, RS, Gruccio, D. Scoliosis in patients treated with growth hormone. J Pediatr Orthop 1997;17:708\u201311. https:\/\/doi.org\/10.1097\/01241398-199711000-00003.","DOI":"10.1097\/01241398-199711000-00003"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_012_w2aab3b7c36b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Yun, YH, Kwon, SS, Koh, Y, Kim, DJ, Ahn, J, Lee, SY. Influence of growth hormone treatment on radiographic indices of the spine: propensity-matched analysis. J Orthop Surg Res 2017;12:130. https:\/\/doi.org\/10.1186\/s13018-017-0630-z.","DOI":"10.1186\/s13018-017-0630-z"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_013_w2aab3b7c36b1b6b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Wit, JM, Clayton, PE, Rogol, AD, Savage, MO, Saenger, PH, Cohen, P. Idiopathic short stature: definition, epidemiology, and diagnostic evaluation. Growth Horm IGF Res 2008;18:89\u2013110. https:\/\/doi.org\/10.1016\/j.ghir.2007.11.004.","DOI":"10.1016\/j.ghir.2007.11.004"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_014_w2aab3b7c36b1b6b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Suh, SW, Modi, HN, Yang, JH, Hong, JY. Idiopathic scoliosis in Korean schoolchildren: a prospective screening study of over 1 million children. Eur Spine J 2011;20:1087\u201394. https:\/\/doi.org\/10.1007\/s00586-011-1695-8.","DOI":"10.1007\/s00586-011-1695-8"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_015_w2aab3b7c36b1b6b1ab2b1c15Aa","doi-asserted-by":"crossref","unstructured":"Quigley, CA, Gill, AM, Crowe, BJ, Robling, K, Chipman, JJ, Rose, SR, et al.. Safety of growth hormone treatment in pediatric patients with idiopathic short stature. J Clin Endocrinol Metab 2005;90:5188\u201396. https:\/\/doi.org\/10.1210\/jc.2004-2543.","DOI":"10.1210\/jc.2004-2543"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_016_w2aab3b7c36b1b6b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Day, GA, McPhee, IB, Batch, J, Tomlinson, FH. Growth rates and the prevalence and progression of scoliosis in short-statured children on Australian growth hormone treatment programmes. Scoliosis 2007;2:3. https:\/\/doi.org\/10.1186\/1748-7161-2-3.","DOI":"10.1186\/1748-7161-2-3"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_017_w2aab3b7c36b1b6b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Sung, IK. Monitoring growth in childhood: practical clinical guide. J Korean Med Assoc 2009;52:211\u201324. https:\/\/doi.org\/10.5124\/jkma.2009.52.3.211.","DOI":"10.5124\/jkma.2009.52.3.211"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_018_w2aab3b7c36b1b6b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Goldberg, CJ, Moore, DP, Fogarty, EE, Dowling, FE. Scoliosis: a review. Pediatr Surg Int 2008;24:129\u201344. https:\/\/doi.org\/10.1007\/s00383-007-2016-5.","DOI":"10.1007\/s00383-007-2016-5"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_019_w2aab3b7c36b1b6b1ab2b1c19Aa","unstructured":"Reamy, BV, Slakey, J. Adolescent idiopathic scoliosis: review and current concepts. Am Fam Physician 2001;64:111."},{"key":"2023040100571175878_j_jpem-2020-0393_ref_020_w2aab3b7c36b1b6b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Ohtsuka, Y, Yamagata, M, Arai, S, Kitahara, H, Minami, S. School screening for scoliosis by the Chiba University Medical School screening program. Results of 1.24 million students over an eight-year period. Spine 1988;13:1251\u20137. https:\/\/doi.org\/10.1097\/00007632-198811000-00008.","DOI":"10.1097\/00007632-198811000-00008"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_021_w2aab3b7c36b1b6b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Wong, H-K, Hui, JH, Rajan, U, Chia, H-P. Idiopathic scoliosis in Singapore schoolchildren: a prevalence study 15 years into the screening program. Spine 2005;30:1188\u201396. https:\/\/doi.org\/10.1097\/01.brs.0000162280.95076.bb.","DOI":"10.1097\/01.brs.0000162280.95076.bb"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_022_w2aab3b7c36b1b6b1ab2b1c22Aa","doi-asserted-by":"crossref","unstructured":"Lonstein, JE, Carlson, JM. The prediction of curve progression in untreated idiopathic scoliosis during growth. J Bone Joint Surg Am 1984;66:1061\u201371. https:\/\/doi.org\/10.2106\/00004623-198466070-00013.","DOI":"10.2106\/00004623-198466070-00013"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_023_w2aab3b7c36b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"Trobisch, P, Suess, O, Schwab, F. Idiopathic scoliosis. Dtsch Arztebl Int 2010;107:875\u201383. https:\/\/doi.org\/10.3238\/arztebl.2010.0875 quiz 84.","DOI":"10.3238\/arztebl.2010.0875"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_024_w2aab3b7c36b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Hresko, MT. Clinical practice. Idiopathic scoliosis in adolescents. N Engl J Med 2013;368:834\u201341. https:\/\/doi.org\/10.1056\/nejmcp1209063.","DOI":"10.1056\/NEJMcp1209063"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_025_w2aab3b7c36b1b6b1ab2b1c25Aa","doi-asserted-by":"crossref","unstructured":"Cheung, JPY, Cheung, PWH, Samartzis, D, Luk, KD-K. APSS-ASJ best clinical research award: predictability of curve progression in adolescent idiopathic scoliosis using the distal radius and ulna classification. Asian spine journal 2018;12:202. https:\/\/doi.org\/10.4184\/asj.2018.12.2.202.","DOI":"10.4184\/asj.2018.12.2.202"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_026_w2aab3b7c36b1b6b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"Zhang, J, Cheuk, KY, Xu, L, Wang, Y, Feng, Z, Sit, T, et al.. A validated composite model to predict risk of curve progression in adolescent idiopathic scoliosis. E Clin Med 2020;18:100236. https:\/\/doi.org\/10.1016\/j.eclinm.2019.12.006.","DOI":"10.1016\/j.eclinm.2019.12.006"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_027_w2aab3b7c36b1b6b1ab2b1c27Aa","doi-asserted-by":"crossref","unstructured":"Fukami, M, Seki, A, Ogata, T. SHOX haploinsufficiency as a cause of syndromic and nonsyndromic short stature. Mol Syndromol 2016;7:3\u201311. https:\/\/doi.org\/10.1159\/000444596.","DOI":"10.1159\/000444596"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_028_w2aab3b7c36b1b6b1ab2b1c28Aa","doi-asserted-by":"crossref","unstructured":"Petteys, RJ, Spitz, SM, Goodwin, CR, Abu-Bonsrah, N, Bydon, A, Witham, TF, et al.. Factors associated with improved survival following surgery for renal cell carcinoma spinal metastases. Neurosurg Focus 2016;41:E13. https:\/\/doi.org\/10.3171\/2016.5.focus16145.","DOI":"10.3171\/2016.5.FOCUS16145"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_029_w2aab3b7c36b1b6b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Dias, C, Giordano, M, Frechette, R, Bellone, S, Polychronakos, C, Legault, L, et al.. Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature. J Cell Mol Med 2017;21:2985\u201399. https:\/\/doi.org\/10.1111\/jcmm.13210.","DOI":"10.1111\/jcmm.13210"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_030_w2aab3b7c36b1b6b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"Rogers, DG, Aswini, RS. Response to growth hormone treatment in a patient with 18p-syndrome. J Pediatr Endocrinol Metab 2012;25:1023\u20135. https:\/\/doi.org\/10.1515\/jpem-2012-0100.","DOI":"10.1515\/jpem-2012-0100"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_031_w2aab3b7c36b1b6b1ab2b1c31Aa","doi-asserted-by":"crossref","unstructured":"Rogers, DG, Nasomyont, N. Growth hormone treatment in a patient with Hurler-Scheie syndrome. J Pediatr Endocrinol Metab 2014;27:957\u201360. https:\/\/doi.org\/10.1515\/jpem-2013-0340.","DOI":"10.1515\/jpem-2013-0340"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_032_w2aab3b7c36b1b6b1ab2b1c32Aa","doi-asserted-by":"crossref","unstructured":"Inzaghi, E, Reiter, E, Cianfarani, S. The challenge of defining and investigating the causes of idiopathic short stature and finding an effective therapy. Horm Res Paediatr 2019;92:71\u201383. https:\/\/doi.org\/10.1159\/000502901.","DOI":"10.1159\/000502901"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_033_w2aab3b7c36b1b6b1ab2b1c33Aa","doi-asserted-by":"crossref","unstructured":"Cohen, P, Bright, GM, Rogol, AD, Kappelgaard, AM, Rosenfeld, RG. American norditropin clinical trials group. Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. J Clin Endocrinol Metab 2002;87:90\u20138. https:\/\/doi.org\/10.1210\/jcem.87.1.8150.","DOI":"10.1210\/jcem.87.1.8150"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_034_w2aab3b7c36b1b6b1ab2b1c34Aa","doi-asserted-by":"crossref","unstructured":"Cohen, P, Rogol, AD, Deal, CL, Saenger, P, Reiter, EO, Ross, JL, et al.. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the growth hormone research society, the lawson wilkins pediatric endocrine society, and the European society for paediatric endocrinology workshop. J Clin Endocrinol Metab 2008;93:4210\u20137. https:\/\/doi.org\/10.1210\/jc.2008-0509.","DOI":"10.1210\/jc.2008-0509"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_035_w2aab3b7c36b1b6b1ab2b1c35Aa","doi-asserted-by":"crossref","unstructured":"Poidvin, A, Carel, JC, Ecosse, E, Levy, D, Michon, J, Coste, J. Increased risk of bone tumors after growth hormone treatment in childhood: a population-based cohort study in France. Cancer Med 2018;7:3465\u201373. https:\/\/doi.org\/10.1002\/cam4.1602.","DOI":"10.1002\/cam4.1602"},{"key":"2023040100571175878_j_jpem-2020-0393_ref_036_w2aab3b7c36b1b6b1ab2b1c36Aa","doi-asserted-by":"crossref","unstructured":"Okuda, A, Shigematsu, H, Fujii, H, Iwata, E, Tanaka, M, Morimoto, Y, et al.. Reliability comparison between \u201cdistal radius and ulna\u201d and \u201csimplified tanner\u2013whitehouse III\u201d assessments for patients with adolescent idiopathic scoliosis. Asian Spine J 2020;14:280\u20136. https:\/\/doi.org\/10.31616\/asj.2019.0162.","DOI":"10.31616\/asj.2019.0162"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpem\/ahead-of-print\/article-10.1515-jpem-2020-0393\/article-10.1515-jpem-2020-0393.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0393\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0393\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T17:23:45Z","timestamp":1680369825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0393\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,12,14]]},"published-print":{"date-parts":[[2021,2,23]]}},"alternative-id":["10.1515\/jpem-2020-0393"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2020-0393","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,13]]}}}