{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:35:27Z","timestamp":1791974127780,"version":"4.4.0"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0426_abs_001_w2aab3b7c72b1b6b1aab1c16b1Aa\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Multisystem inflammatory syndrome in children (MIS-C) is a unique clinical complication of SARS-CoV-2 infection observed in pediatric patients. COVID-19 is emerging as a potential trigger for the development of diabetes in children. Here, we report a patient presenting with MIS-C and new onset diabetes, and discuss the implication and clinical management of these concomitant conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0426_abs_002_w2aab3b7c72b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>An eight-year-old female presented with hyperglycemia, ketosis and metabolic acidosis consistent with diabetic ketoacidosis (DKA) in the setting of fever, rash, respiratory distress, hemodynamic instability, reduced systolic function with dilation of the left anterior descending artery, and positive SARS-CoV-2 antibodies suggestive of MIS-C.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0426","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:01:42Z","timestamp":1605600102000},"page":"147-150","source":"Crossref","is-referenced-by-count":39,"title":["New onset diabetes with diabetic ketoacidosis in a child with multisystem inflammatory syndrome due to COVID-19"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-8332","authenticated-orcid":false,"given":"Monica N.","family":"Naguib","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Los Angeles , Los Angeles , CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Raymond","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Los Angeles , Los Angeles , CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaina P.","family":"Vidmar","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Los Angeles , Los Angeles , CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2023040101232132865_j_jpem-2020-0426_ref_001_w2aab3b7c72b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Huang, I, Lim, MA, Pranata, R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia\u00a0\u2013 a systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr 2020;14:395\u2013403. https:\/\/doi.org\/10.1016\/j.dsx.2020.04.018.","DOI":"10.1016\/j.dsx.2020.04.018"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_002_w2aab3b7c72b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Liguoro, I, Pilotto, C, Bonanni, M, Ferrari, ME, Pusiol, A, Nocerino, A, et al.. SARS-COV-2 infection in children and newborns: a systematic review. Eur J Pediatr 2020;179:1029\u201346. https:\/\/doi.org\/10.1007\/s00431-020-03684-7.","DOI":"10.1007\/s00431-020-03684-7"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_003_w2aab3b7c72b1b6b1ab2b2b3Aa","unstructured":"Centers for Disease Control and Prevention. Health alert network (HAN) health advisory. Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). Available from: https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp [Accessed 23 Jun 2020]."},{"key":"2023040101232132865_j_jpem-2020-0426_ref_004_w2aab3b7c72b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Hamman, RF, Bell, RA, Dabelea, D, D\u2019Agostino, RB, Dolan, L, Imperatore, G, et al.. The search for diabetes in youth study: rationale, findings, and future directions. Diabetes Care 2014;37:3336\u201344. https:\/\/doi.org\/10.2337\/dc14-0574.","DOI":"10.2337\/dc14-0574"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_005_w2aab3b7c72b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Belhadjer, Z, M\u00e9ot, M, Bajolle, F, Khraiche, D, Legendre, A, Abakka, S, et al.. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation 2020. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.048360 [Epub ahead of print].","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_006_w2aab3b7c72b1b6b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Whittaker, E, Bamford, A, Kenny, J, Kaforou, M, Jones, CE, Shah, P, et al.. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. J Am Med Assoc 2020. https:\/\/doi.org\/10.1001\/jama.2020.10369 [Epub ahead of print].","DOI":"10.1001\/jama.2020.10369"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_007_w2aab3b7c72b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Bhowmick, SK, Estrada, B, Rettig, KR. Insulin-dependent diabetes mellitus in two male African American children after Kawasaki disease. Pediatrics 2002;110:e27. https:\/\/doi.org\/10.1542\/peds.110.2.e27.","DOI":"10.1542\/peds.110.2.e27"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_008_w2aab3b7c72b1b6b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Yang, JK, Lin, SS, Ji, XJ, Guo, LM. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol 2009;47:193\u20139. https:\/\/doi.org\/10.1007\/s00592-009-0109-4.","DOI":"10.1007\/s00592-009-0109-4"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_009_w2aab3b7c72b1b6b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Fu, Y, Cheng, Y, Wu, Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol Sin 2020;35:266\u201371. https:\/\/doi.org\/10.1007\/s12250-020-00207-4.","DOI":"10.1007\/s12250-020-00207-4"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_010_w2aab3b7c72b1b6b1ab2b2c10Aa","doi-asserted-by":"crossref","unstructured":"Chee, YJ, Ng, SJ, Yeoh, E. Diabetic ketoacidosis precipitated by Covid-19 in a patient with newly diagnosed diabetes mellitus [Letter]. Diabetes Res Clin Pract 2020;164:108166. https:\/\/doi.org\/10.1016\/j.diabres.2020.108166.","DOI":"10.1016\/j.diabres.2020.108166"},{"key":"2023040101232132865_j_jpem-2020-0426_ref_011_w2aab3b7c72b1b6b1ab2b2c11Aa","doi-asserted-by":"crossref","unstructured":"Li, J, Wang, X, Chen, J, Zuo, X, Zhang, H, Deng, A. COVID-19 infection may cause ketosis and ketoacidosis. Diabetes Obes Metabol 2020. https:\/\/doi.org\/10.1111\/dom.14057 [Epub ahead of print].","DOI":"10.1111\/dom.14057"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpem\/34\/1\/article-p147.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0426\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0426\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T20:01:47Z","timestamp":1680379307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0426\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,11,12]]},"published-print":{"date-parts":[[2021,1,27]]}},"alternative-id":["10.1515\/jpem-2020-0426"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2020-0426","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,12]]}}}