{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:36:46Z","timestamp":1793504206335,"version":"4.5.0"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0442_abs_001_w2aab3b7c79b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Ectopic adrenocorticotropic syndrome (EAS) causes approximately 10\u201318% of cases of Cushing\u2019s syndrome (CS) in adults, while in children it occurs much less frequently.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0442_abs_003_w2aab3b7c79b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We report two cases of neuroendocrine tumors (of the thymus and the appendix) in a 12-year-old boy and a 15-year-old girl who presented with the clinical features of CS. Elevated serum cortisol, ACTH, and chromogranin levels were observed in both patients. Diagnoses were made on the basis of a mass in the thymus\/appendix region visualized with chest\/abdominal CT scan and radiotracer accumulation in scintigraphy in the same areas. Histopathological examinations confirmed the diagnoses of NET.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0442_abs_004_w2aab3b7c79b1b6b1aab1c16b3Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>EAS is an extremely rare endocrine disorder. However, it should be taken into consideration in the diagnostic process of every case of ACTH-dependent CS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0442","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:10:22Z","timestamp":1605600622000},"page":"141-146","source":"Crossref","is-referenced-by-count":8,"title":["Ectopic ACTH production by thymic and appendiceal neuroendocrine tumors\u00a0\u2013 two case reports"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-7003","authenticated-orcid":false,"given":"El\u017cbieta","family":"Moszczy\u0144ska","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-5023","authenticated-orcid":false,"given":"Katarzyna","family":"Pasternak-Pietrzak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Prokop-Piotrkowska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"\u015aliwi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Szyma\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pathology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieczys\u0142aw","family":"Szalecki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology , The Children\u2019s Memorial Health Institute , Warsaw , Poland"},{"name":"Collegium Medicum , Jan Kochanowski University , Kielce , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2023040101232103929_j_jpem-2020-0442_ref_001_w2aab3b7c79b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ilias, I, Torpy, DJ, Pacak, K, Mullen, N, Wesley, RA, Nieman, LK. 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