{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:09:44Z","timestamp":1787022584087,"version":"build-2736575974"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"crossref","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2020-0470_abs_002_w2aab3b7c33b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine appetite-regulating hormone levels in girls with central precocious puberty (CPP) before and after 20\u00a0weeks of gonadotropin-releasing hormone analogue (GnRH-A) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0470_abs_003_w2aab3b7c33b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen newly diagnosed CPP girls were enrolled. Body composition measured by bioelectrical impedance analysis and GnRH-A test were performed with fasting serum leptin, ghrelin and peptide YY (PYY) measurements at baseline (before) and after 20 weeks of GnRH-A treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0470_abs_004_w2aab3b7c33b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following GnRH-A treatment, all patients had prepubertal gonadotropin and estradiol levels. Mean (SD) fat mass index (FMI) was significantly increased from 4.5 (1.7) to 5.0 (1.8) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      after treatment. Also, median (IQR) serum leptin level was significantly increased from 6.9 (4.2\u20138.6) to 7.4 (5.3\u201313.1) ng\/mL. FMI had a positive correlation with serum leptin level (r=0.64, p=0.004). In contrast, no significant changes of serum ghrelin and PYY levels were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0470_abs_005_w2aab3b7c33b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Decreased estrogen following short-term GnRH-A treatment in CPP girls may cause an increase in appetite and consequently an elevation of FMI. Increased serum leptin may be a result of having increased FMI secondary to an increase in appetite.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2020-0470","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T03:38:24Z","timestamp":1614742704000},"page":"479-484","source":"Crossref","is-referenced-by-count":7,"title":["Short-term effects of gonadotropin-releasing hormone analogue treatment on leptin, ghrelin and peptide YY in girls with central precocious puberty"],"prefix":"10.1515","volume":"34","author":[{"given":"Piyathida","family":"Wijarn","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preamrudee","family":"Poomthavorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patcharin","family":"Khlairit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarunyu","family":"Pongratanakul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laor","family":"Chailurkit","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Mahachoklertwattana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2023040101452969690_j_jpem-2020-0470_ref_001_w2aab3b7c33b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Grumbach, MM. 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