{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:32Z","timestamp":1747198232272,"version":"3.40.5"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0499_abs_001_w2aab3b7b7b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Pituitary apoplexy is a rare complication of Cushing\u2019s disease (CD), especially in the paediatric age and even more rarely it can occur following anterior pituitary stimulation tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0499_abs_002_w2aab3b7b7b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We report a case of a 14-year-old girl who was admitted to our Hospital for evaluation of a possible Cushing\u2019s syndrome (CS). Her symptoms and initial laboratory tests were suggestive of CD. Magnetic resonance imaging (MRI) revealed a microadenoma of the pituitary gland. As part of her evaluation she was submitted to a corticotropin-releasing hormone (CRH) stimulation test. Two and a half months later the patient was re-evaluated and presented with both clinical improvement of CS, biochemical resolution of hypercortisolism and tumour size reduction in the MRI, also evidencing a haemorrhagic component favouring the diagnosis of pituitary apoplexy after CRH stimulation test. The patient denied any episodes of severe headache, nausea, vomiting or visual changes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0499_abs_003_w2aab3b7b7b1b6b1aab1c16b3Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>To our knowledge, the authors report the first case of a pituitary apoplexy after a CRH stimulation test in the paediatric age.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0499","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T08:31:53Z","timestamp":1617611513000},"page":"799-803","source":"Crossref","is-referenced-by-count":3,"title":["Asymptomatic pituitary apoplexy induced by corticotropin-releasing hormone in a 14 year-old girl with Cushing\u2019s disease"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-8308","authenticated-orcid":false,"given":"Liliana","family":"Fonseca","sequence":"first","affiliation":[{"name":"Endocrinology Department , Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Borges Duarte","sequence":"additional","affiliation":[{"name":"Endocrinology Department , Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Freitas","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology Unit , Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology Unit , Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Neurosurgery Department , Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Amaral","sequence":"additional","affiliation":[{"name":"Endocrinology Department , Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Borges","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology Unit , Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"2023040101193740943_j_jpem-2020-0499_ref_001_w2aab3b7b7b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"W\u0119drychowicz, A, Hull, B, Tyrawa, K, Kalicka-Kasperczyk, A, Zieli\u0144ski, G, Starzyk, J. 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