{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T22:37:20Z","timestamp":1779057440439,"version":"3.51.4"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2020-0503_abs_001_w2aab3b7c42b1b6b1aab1c16b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Coronavirus disease (COVID-19) rapidly spread worldwide in a few months and was declared as a worldwide pandemic by WHO in March 2020. Transient benign hyperphosphatasemia (THI) is a benign condition associated with marked elevation of alkaline phosphatase (ALP) without any other kidney, bone, and liver pathologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0503_abs_002_w2aab3b7c42b1b6b1aab1c16b2Aa\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>Herein, we report a previously healthy 16-month-old female patient who developed a secondary transient benign hyperphosphatasemia associated with SARS-CoV-2. Patient whole family\u2019s SARS-CoV-2 real-time reverse transcription-polymerase chain reaction (RT-PCR) results were positive. Since THI is a diagnosis of exclusion, other reasons that may cause ALP elevation should be ruled out. ALP activity decreased and turned to normal ranges within the following month. THI has been reported to be in association with various conditions. Its relationship with many viruses has been reported previously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2020-0503_abs_003_w2aab3b7c42b1b6b1aab1c16b3Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>If ALP elevation is detected in patients with COVID 19 due to the increasing number of infections, THI should be considered if there is no other accompanying pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2020-0503","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T05:55:53Z","timestamp":1608616553000},"page":"385-387","source":"Crossref","is-referenced-by-count":9,"title":["Transient benign hyperphosphatasemia due to COVID-19: the first case report"],"prefix":"10.1515","volume":"34","author":[{"given":"Tugba","family":"Erat","sequence":"first","affiliation":[{"name":"Sanl\u0131urfa Training and Research Hospital, Clinic of Pediatric Endocrinology , Sanl\u0131urfa , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcge","family":"Atar","sequence":"additional","affiliation":[{"name":"Sanl\u0131urfa Training and Research Hospital, Clinic of Pediatric Endocrinology , Sanl\u0131urfa , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-8580","authenticated-orcid":false,"given":"Tugba","family":"Kontbay","sequence":"additional","affiliation":[{"name":"Sanl\u0131urfa Training and Research Hospital, Clinic of Pediatric Endocrinology , Sanl\u0131urfa , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"2026011412095449699_j_jpem-2020-0503_ref_001_w2aab3b7c42b1b6b1ab2b1b1Aa","unstructured":"https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019. [Accessed:26 August 2020]."},{"key":"2026011412095449699_j_jpem-2020-0503_ref_002_w2aab3b7c42b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Teitelbaum, JE, Laskowski, A, Barrows, FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011;24:93\u20135. https:\/\/doi.org\/10.1515\/jpem.2011.077.","DOI":"10.1515\/jpem.2011.077"},{"key":"2026011412095449699_j_jpem-2020-0503_ref_003_w2aab3b7c42b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Kutilek, S, Cervickova, B, Bebova, P, Kmonickova, M, Nemec, V. Normal bone turnover in transient hyperphosphatasemia. J Clin Res Pediatr Endocrinol 2012;4:154\u20136. https:\/\/doi.org\/10.4274\/jcrpe.680.","DOI":"10.4274\/Jcrpe.680"},{"key":"2026011412095449699_j_jpem-2020-0503_ref_004_w2aab3b7c42b1b6b1ab2b1b4Aa","unstructured":"Goto, M. Is respiratory syncytial virus one of the causative agents for transient hyperphosphatasemia? Rinsho Byori 2002;50:1146\u20139."},{"key":"2026011412095449699_j_jpem-2020-0503_ref_005_w2aab3b7c42b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Koike, Y, Aoki, N. Benign transient hyperphosphatasemia associated with Epstein-Barr virus infection. Pediatr Int 2013;55:667\u20138. https:\/\/doi.org\/10.1111\/ped.12173.","DOI":"10.1111\/ped.12173"},{"key":"2026011412095449699_j_jpem-2020-0503_ref_006_w2aab3b7c42b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Akcaboy, M, Zorlu, P, Acoglu, EA, Acar, M, Oguz, MM, Senel, S. Human Bocavirus infection associated transient benign hyperphosphatasemia in an infant. Indian J Pediatr 2016;83:902\u20133. https:\/\/doi.org\/10.1007\/s12098-016-2156-5.","DOI":"10.1007\/s12098-016-2156-5"},{"key":"2026011412095449699_j_jpem-2020-0503_ref_007_w2aab3b7c42b1b6b1ab2b1b7Aa","unstructured":"Marrali, V, Cutaia, A, Zarbo, C, Meli, G, Fragapane, D, Mandini, A. Transient idiopathic hyperphosphatasemia in rotavirus infection. Minerva Pediatr 1990;42:559\u201360."},{"key":"2026011412095449699_j_jpem-2020-0503_ref_008_w2aab3b7c42b1b6b1ab2b1b8Aa","unstructured":"Suzuki, M, Okazaki, T, Asahara, M, Kadohno, N, Kanno, T. Pathophysiological background of transient hyperphosphatasemia. Rinsho Byori 1998;46:88\u201390."},{"key":"2026011412095449699_j_jpem-2020-0503_ref_009_w2aab3b7c42b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Tezer, H, Bedir Demirda\u011f, T. Novel coronavirus disease (COVID-19) in children. Turk J Med Sci 2020;50:592\u2013603. https:\/\/doi.org\/10.3906\/sag-2004-174.","DOI":"10.3906\/sag-2004-174"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpem\/ahead-of-print\/article-10.1515-jpem-2020-0503\/article-10.1515-jpem-2020-0503.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2020-0503\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2020-0503\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:09:59Z","timestamp":1768392599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2020-0503\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,12,14]]},"published-print":{"date-parts":[[2021,3,26]]}},"alternative-id":["10.1515\/jpem-2020-0503"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2020-0503","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,14]]}}}