{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:44:11Z","timestamp":1778535851324,"version":"3.51.4"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0535_abs_001_w2aab3b7c46b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>IgG4-related hypophysitis is a novel clinical disease entity, which is typically seen in the sixth decade of life and is typically complicated by hypopituitarism. We describe an adolescent female with IgG4-related hypophysitis with normal pituitary function and summarize the relevant literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0535_abs_002_w2aab3b7c46b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 11.8-year-old girl presented with headache and left VI cranial nerve palsy. MRI brain identified an enlarged pituitary gland. Endocrine investigations revealed normal pituitary function. She underwent a transsphenoidal biopsy of the pituitary gland, and histological examination confirmed the diagnosis of IgG4-related hypophysitis. Serum IgG4 concentrations were normal and no evidence of other organ involvement was found. Although the patient tested strongly positive for TB on an interferon gamma release assay, pituitary biopsy was negative for granuloma formation and acid-fast bacilli (Ziehl-Neelson staining). IgG4-related hypophysitis was treated with oral prednisolone and mycophenolate-mofetil with a good response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0535_abs_003_w2aab3b7c46b1b6b1aab1c16b3Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We describe to the best of our knowledge, the youngest patient in the published literature with IgG4-related hypophysitis presenting without pituitary insufficiency. A literature review identified only five cases of IgG4-related hypophysitis in adolescence. Serum IgG4 concentrations were normal in all, except one of the adolescent patients reported so far, and appear unhelpful in diagnosis in this age group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0535","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T14:54:32Z","timestamp":1608648872000},"page":"395-399","source":"Crossref","is-referenced-by-count":8,"title":["IgG4-related hypophysitis in adolescence"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7416-003X","authenticated-orcid":false,"given":"Ved Bhushan","family":"Arya","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology , Variety Children Hospital, King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarra Abu","family":"El-Gasim","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology , Variety Children Hospital, King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreena","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , Variety Children Hospital, King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita","family":"Reisz","sequence":"additional","affiliation":[{"name":"Department of Neuropathology , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassel","family":"Zebian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"D\u2019Cruz","sequence":"additional","affiliation":[{"name":"Louise Coote Unit , Guy\u2019s and St Thomas NHS Foundation Trust , London , UK"},{"name":"Division of Immunology, Infection and Inflammatory Diseases , King\u2019s College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"King","sequence":"additional","affiliation":[{"name":"Department of Neuropathology , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Hampton","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.\u00a0B.","family":"Aylwin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritika R.","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology , Variety Children Hospital, King\u2019s College Hospital NHS Foundation Trust , London , UK"},{"name":"Faculty of Medicine and Life Science , King\u2019s College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology , Variety Children Hospital, King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"2023040101391767342_j_jpem-2020-0535_ref_001_w2aab3b7c46b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Stone, JH, Zen, Y, Deshpande, V. 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