{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:02:25Z","timestamp":1742382145019},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0683_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To study the effect of combined gonadotropin therapy (CGT) on testicular descent\u00a0\u00b1\u00a0spermatogenesis in congenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism beyond infancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0683_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study included CHH patients with cryptorchidism [bilateral (n=5) or unilateral (n=1)] treated with CGT for testicular descent\u00a0\u00b1\u00a0pubertal induction. All participants were treated with CGT [human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG)] with hMG pretreatment in three and monitored for changes in testicular volume (TV), serum total testosterone (T), serum inhibin-B, and sperm concentration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0683_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Complete testicular descent to the scrotal position was achieved in 5\/6 patients (10\/11 testes) after 4.7\u00a0\u00b1\u00a01.6\u00a0months of treatment. There was 44\u00a0\u00b1\u00a018%, 97.5% (IQR: 44\u2013195), 10-fold (IQR: 3\u201319.6), and two-fold (IQR: 1.7\u20139.3) increase in stretched penile length, ultrasound measured TV, T level, and serum inhibin-B from baseline, respectively. In two pediatric cases, testicular descent occurred with isolated hMG therapy. At the last follow up (median: 23.5, IQR: 10.5\u201338.7\u00a0months), all the descended testes remained in scrotal position. In four pubertal\/postpubertal age patients, continuous CGT (18\u201360\u00a0months) yielded T and inhibin-B levels of 16.64\u00a0\u00b1\u00a01.46\u00a0nmol\/l and 106\u00a0\u00b1\u00a032.6\u00a0pg\/mL, respectively. All the three patients with available semen analysis had sperm concentration of\u00a0\u22655 million\/mL and one of them achieved paternity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0683_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A trial of CGT before orchiopexy may be considered in CHH males with cryptorchidism even beyond the narrow age-window of infancy. CGT may also have beneficial effects on future spermatogenesis and fertility outcomes in these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0683","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T20:27:54Z","timestamp":1619296074000},"page":"917-924","source":"Crossref","is-referenced-by-count":2,"title":["Gonadotropins for testicular descent in cryptorchid congenital hypogonadotropic hypogonadism males beyond infancy"],"prefix":"10.1515","volume":"34","author":[{"given":"Shreya","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Endocrinology , Seth GS Medical College and KEM Hospital , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravikumar","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth GS Medical College and KEM Hospital , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virendra","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth GS Medical College and KEM Hospital , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag R.","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth GS Medical College and KEM Hospital , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Sarathi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Vydehi Institute of Medical Sciences and Research Center , Bangalore , Karnataka , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalini","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth GS Medical College and KEM Hospital , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar","family":"Bandgar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Seth GS Medical College and KEM Hospital , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"2023040101233478886_j_jpem-2020-0683_ref_001","doi-asserted-by":"crossref","unstructured":"Swee, DS, Quinton, R. Congenital hypogonadotrophic hypogonadism: minipuberty and the case for neonatal diagnosis. Front Endocrinol (Lausanne) 2019;10:1\u20139. https:\/\/doi.org\/10.3389\/fendo.2019.00097.","DOI":"10.3389\/fendo.2019.00097"},{"key":"2023040101233478886_j_jpem-2020-0683_ref_002","doi-asserted-by":"crossref","unstructured":"Kuiri-H\u00e4nninen, T, Koskenniemi, J, Dunkel, L, Toppari, J, Sankilampi, U. Postnatal testicular activity in healthy boys and boys with cryptorchidism. Front Endocrinol (Lausanne) 2019;10:1\u201312. https:\/\/doi.org\/10.3389\/fendo.2019.00489.","DOI":"10.3389\/fendo.2019.00489"},{"key":"2023040101233478886_j_jpem-2020-0683_ref_003","doi-asserted-by":"crossref","unstructured":"Grinspon, RP, Urrutia, M, Rey, RA. Male central hypogonadism in paediatrics: the relevance of follicle-stimulating hormone and Sertoli cell markers. 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