{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:56:38Z","timestamp":1780386998922,"version":"3.54.1"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0699_abs_001_w2aab3b7c19b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Wolfram syndrome (WS) is a rarely seen autosomal recessive multisystem neurodegenerative disorder caused by mutations in the <jats:italic>WFS1<\/jats:italic> gene.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0699_abs_002_w2aab3b7c19b1b6b1aab1c16b2Aa\">\n                  <jats:title>Case Presentation<\/jats:title>\n                  <jats:p>Three sisters with WS had diabetes mellitus (DM) at 4 years of age and optic atrophy. In addition, the first case had hearing impairment, and the second case had diabetes insipidus and urinary incontinence. Linagliptin was administered to the first case as add-on therapy to intensive insulin treatment 15 years after the onset of DM, and her insulin need showed a dramatic decrease. The third case had a remission phase one month after the onset of DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0699_abs_003_w2aab3b7c19b1b6b1aab1c16b3Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Even in cases with the same mutation, symptoms and findings may widely vary in WS. Remission of diabetes has rarely been reported in WS. Also, this report describes the first trial of a dipeptidyl peptidase-4 inhibitor in a patient with WS which provided a decrease in exogenous insulin need.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0699","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T14:12:30Z","timestamp":1619187150000},"page":"1049-1053","source":"Crossref","is-referenced-by-count":4,"title":["Different clinical entities of the same mutation: a case report of three sisters with Wolfram syndrome and efficacy of dipeptidyl peptidase-4 inhibitor therapy"],"prefix":"10.1515","volume":"34","author":[{"given":"Gurkan","family":"Tarcin","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology , Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-9241","authenticated-orcid":false,"given":"Aydilek","family":"Dagdeviren Cakir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Ozer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayca","family":"Aykut","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics , Ege University Faculty of Medicine , Izmir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asude","family":"Alpman Durmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics , Ege University Faculty of Medicine , Izmir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oya","family":"Ercan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-8637","authenticated-orcid":false,"given":"Olcay","family":"Evliyaoglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"2023040101170324572_j_jpem-2020-0699_ref_001_w2aab3b7c19b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Toppings, NB, McMillan, JM, Au, PYB, Suchowersky, O, Donovan, LE. 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