{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:59:36Z","timestamp":1777658376788,"version":"3.51.4"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2020-0741_abs_001_w2aab3b7c33b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Medium-chain (MCA) and long-chain acylcarnitine (LCA) blood concentrations play a significant role in the fatty acid (FA) oxidation process, especially during the first days of life. Identification of their abnormal concentrations, <jats:italic>via<\/jats:italic> expanded newborn screening, can lead to the diagnosis of FA oxidation disorders. This study aimed to demonstrate MCA and LCA concentrations in Dried Blood Spots (DBS) of full-term breastfed infants, in relation to their birth weight (BW) perinatally.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0741_abs_002_w2aab3b7c33b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Breastfed full-term infants (n\u00a0=\u00a012,000, 6,000 males, 6,000 females) with BW 2,000\u20133,999\u00a0g were divided into four equal groups: Group A, 2,000\u20132,499\u00a0g, B 2,500\u20132,999\u00a0g, C 3,000\u20133,499\u00a0g, and D 3,500\u20133,999\u00a0g. Samples were collected as DBS and acylcarnitines were determined <jats:italic>via<\/jats:italic> a liquid chromatography tandem mass spectrometry method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0741_abs_003_w2aab3b7c33b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MCA and LCA blood concentrations were determined significantly lower in group A (low birth weight infants) in both sexes. Infants with BW\u00a0&gt;\u00a03,500\u00a0g (group D), were characterized by lower levels of C10, C10:1, C14, C14:1 acylcarnitines and higher levels of C16 and C18:1 acylcarnitines, as compared to the other groups of this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2020-0741_abs_004_w2aab3b7c33b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Concentration patterns in full-term breastfed newborns in relation to sex and mainly BW found in this study could be very helpful for neonatologists, especially for newborns of group A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2020-0741","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:11:46Z","timestamp":1624572706000},"page":"1023-1030","source":"Crossref","is-referenced-by-count":4,"title":["Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns"],"prefix":"10.1515","volume":"34","author":[{"given":"Penelope D.","family":"Manta-Vogli","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics , Agia Sofia Children\u2019s Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleopatra H.","family":"Schulpis","sequence":"additional","affiliation":[{"name":"Institute of Child Health, Agia Sofia Children\u2019s Hospital , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannis L.","family":"Loukas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Laboratory of Pharm. Analysis, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-8286","authenticated-orcid":false,"given":"Yannis","family":"Dotsikas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Laboratory of Pharm. Analysis, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"2023040101170325399_j_jpem-2020-0741_ref_001_w2aab3b7c33b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"McCandless, SE, Wright, EJ. Mandatory newborn screening in the United States: history, current status, and existential challenges. Birth Defects Res 2020;112:350\u201366. https:\/\/doi.org\/10.1002\/bdr2.1653.","DOI":"10.1002\/bdr2.1653"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_002_w2aab3b7c33b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Ozben, T. Expanded newborn screening and confirmatory follow-up testing for inborn errors of metabolism detected by tandem mass spectrometry. Clin Chem Lab Med 2013;51:157\u201376. https:\/\/doi.org\/10.1515\/cclm-2012-0472.","DOI":"10.1515\/cclm-2012-0472"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_003_w2aab3b7c33b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Longo, N, Frigeni, M, Pasquali, M. Carnitine transport and fatty acid oxidation. Biochim Biophys Acta 2016;1863:2422\u201335. https:\/\/doi.org\/10.1016\/j.bbamcr.2016.01.023.","DOI":"10.1016\/j.bbamcr.2016.01.023"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_004_w2aab3b7c33b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Wanders, RJ, Ruiter, JP, IJlst, L, Waterham, HR, Houten, SM. The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results. J Inherit Metab Dis 2010;33:479\u201394. https:\/\/doi.org\/10.1007\/s10545-010-9104-8.","DOI":"10.1007\/s10545-010-9104-8"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_005_w2aab3b7c33b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Sharpe, AJ, McKenzie, M. Mitochondrial fatty acid oxidation disorders associated with short-chain enoyl-coA hydratase (ESHS1) deficiency. Cells 2018;23:7.","DOI":"10.3390\/cells7060046"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_006_w2aab3b7c33b1b6b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Wajner, M, Amaral, AU. Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies. Biosci Rep 2015;36:e00281. https:\/\/doi.org\/10.1042\/BSR20150240.","DOI":"10.1042\/BSR20150240"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_007_w2aab3b7c33b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Manta-Vogli, PD, Schulpis, KH, Dotsikas, Y, Loukas, YL. The significant role of carnitine and fatty acids during pregnancy, lactation and perinatal period. Nutritional support in specific groups of pregnant women. Clin Nutr 2020;39:2337\u201346. https:\/\/doi.org\/10.1016\/j.clnu.2019.10.025.","DOI":"10.1016\/j.clnu.2019.10.025"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_008_w2aab3b7c33b1b6b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Hachey, DL, Silber, GH, Wong, WW, Garza, C. Human lactation. II: Endogenous fatty acid synthesis by the mammary gland. Pediatr Res 1989;25:63\u20138. https:\/\/doi.org\/10.1203\/00006450-198901000-00015.","DOI":"10.1203\/00006450-198901000-00015"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_009_w2aab3b7c33b1b6b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Sinanoglou, VJ, Cavouras, D, Boutsikou, T, Briana, D, Lantzouraki, DZ, Paliatsiou, S, et al.. Factors affecting human colostrum fatty acid profile: a case study. PLoS One 2017;12:e0175817. https:\/\/doi.org\/10.1371\/journal.pone.0175817.","DOI":"10.1371\/journal.pone.0175817"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_010_w2aab3b7c33b1b6b1ab2b2c10Aa","doi-asserted-by":"crossref","unstructured":"Andreas, NJ, Kampmann, B, Mehring Le-Doare, K. Human breast milk: a review on its composition and bioactivity. Early Hum Dev 2015;91:629\u201335. https:\/\/doi.org\/10.1016\/j.earlhumdev.2015.08.013.","DOI":"10.1016\/j.earlhumdev.2015.08.013"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_011_w2aab3b7c33b1b6b1ab2b2c11Aa","unstructured":"ELSTAT. Available from: http:\/\/www.statistics.gr [Accessed 15 Dec 2020]."},{"key":"2023040101170325399_j_jpem-2020-0741_ref_012_w2aab3b7c33b1b6b1ab2b2c12Aa","doi-asserted-by":"crossref","unstructured":"Loukas, YL, Soumelas, GS, Dotsikas, Y, Georgiou, V, Molou, E, Thodi, G, et al.. Expanded newborn screening in Greece: 30 months of experience. J Inherit Metab Dis 2010;33:S341\u20138. https:\/\/doi.org\/10.1007\/s10545-010-9181-8.","DOI":"10.1007\/s10545-010-9181-8"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_013_w2aab3b7c33b1b6b1ab2b2c13Aa","doi-asserted-by":"crossref","unstructured":"Tali\u00e1n, GC, Koml\u00f3si, K, Decsi, T, Koletzko, B, Melegh, B. Determination of carnitine ester patterns during the second half of pregnancy, at delivery, and in neonatal cord blood by tandem mass spectrometry: complex and dynamic involvement of carnitine in the intermediary metabolism. Pediatr Res 2007;62:88\u201392. https:\/\/doi.org\/10.1203\/pdr.0b013e3180676cca.","DOI":"10.1203\/PDR.0b013e3180676cca"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_014_w2aab3b7c33b1b6b1ab2b2c14Aa","doi-asserted-by":"crossref","unstructured":"Borum, PR. Role of carnitine during development. Can J Physiol Pharmacol 1985;63:571\u20136. https:\/\/doi.org\/10.1139\/y85-097.","DOI":"10.1139\/y85-097"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_015_w2aab3b7c33b1b6b1ab2b2c15Aa","doi-asserted-by":"crossref","unstructured":"Manta-Vogli, PD, Schulpis, KH, Loukas, YL, Dotsikas, Y. Perinatal free carnitine and short chain acylcarnitine blood concentrations in 12000 full-term breastfed newborns in relation to their birth weight. Pediatr Neonatol 2020;61:620\u20138. https:\/\/doi.org\/10.1016\/j.pedneo.2020.07.015.","DOI":"10.1016\/j.pedneo.2020.07.015"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_016_w2aab3b7c33b1b6b1ab2b2c16Aa","doi-asserted-by":"crossref","unstructured":"Yu, T, Han, Y, Pu, X, Duan, H, Zhi, L, Zhang, Y, et al.. Performance of LC\/MS\/MS in analyzing multiple amino acids and acylcarnitines in dried blood spot of very low birth weight, low birth weight and normal weight neonates. Clin Lab 2018;64:1333\u20139. https:\/\/doi.org\/10.7754\/Clin.Lab.2018.171233.","DOI":"10.7754\/Clin.Lab.2018.171233"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_017_w2aab3b7c33b1b6b1ab2b2c17Aa","unstructured":"Liu, Q, Yin, A, Wen, S, Shi, X, Fang, L, Rao, T, et al.. Analysis of amino acids and acylcarnitines profiles in small, appropriate, and large for gestational age neonates. J Matern Fetal Neonatal Med in press."},{"key":"2023040101170325399_j_jpem-2020-0741_ref_018_w2aab3b7c33b1b6b1ab2b2c18Aa","doi-asserted-by":"crossref","unstructured":"Adeva-Andany, \u039c\u039c, Calvo-Castro, \u0399, Fern\u00e1ndez-Fern\u00e1ndez, C, Donapetry-Garc\u00eda, C, Pedre-Pi\u00f1eiro, AM. Significance of l-carnitine for human health. IUBMB Life 2017;69:578\u201394. https:\/\/doi.org\/10.1002\/iub.1646.","DOI":"10.1002\/iub.1646"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_019_w2aab3b7c33b1b6b1ab2b2c19Aa","doi-asserted-by":"crossref","unstructured":"Manta-Vogli, PD, Schulpis, KH, Loukas, YL, Dotsikas, Y. Birth weight related essential, non-essential and conditionally essential amino acid blood concentrations in 12,000 breastfed full-term infants perinatally. Scand J Clin Lab Invest 2020;80:571\u20139. https:\/\/doi.org\/10.1080\/00365513.2020.1818280.","DOI":"10.1080\/00365513.2020.1818280"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_020_w2aab3b7c33b1b6b1ab2b2c20Aa","doi-asserted-by":"crossref","unstructured":"Vidarsdottir, H, Thorkelsson, T, Halldorsson, TI, Bjarnason, R, Geirsson, RT, Rinaldo, P, et al.. Does metabolomic profile differ with regard to birth weight?. Pediatr Res 2020;89:1144\u201351. https:\/\/doi.org\/10.1038\/s41390-020-1033-0.","DOI":"10.1038\/s41390-020-1033-0"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_021_w2aab3b7c33b1b6b1ab2b2c21Aa","doi-asserted-by":"crossref","unstructured":"Liu, J, Chen, XX, Li, XW, Fu, W, Zhang, WQ. Metabolomic research on newborn infants with intrauterine growth restriction. Medicine (Baltim) 2016;95:e3564. https:\/\/doi.org\/10.1097\/md.0000000000003564.","DOI":"10.1097\/MD.0000000000003564"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_022_w2aab3b7c33b1b6b1ab2b2c22Aa","doi-asserted-by":"crossref","unstructured":"Lee, W, Riggs, T, Koo, W, Deter, RL, Yeo, L, Romero, R. The relationship of newborn adiposity to fetal growth outcome based on birth weight or the modified neonatal growth assessment score. J Matern Fetal Neonatal Med 2012;25:1933\u201340. https:\/\/doi.org\/10.3109\/14767058.2012.683084.","DOI":"10.3109\/14767058.2012.683084"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_023_w2aab3b7c33b1b6b1ab2b2c23Aa","doi-asserted-by":"crossref","unstructured":"Adeva-Andany, MM, Perez-Felpete, N, Fernandez-Fernandez, C, Donapetry-Garcia, C, Pazos-Garcia, C. Liver glucose metabolism in humans. Biosci Rep 2016;36:e00416. https:\/\/doi.org\/10.1042\/BSR20160385.","DOI":"10.1042\/BSR20160385"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_024_w2aab3b7c33b1b6b1ab2b2c24Aa","doi-asserted-by":"crossref","unstructured":"Kadakia, R, Scholtens, DM, Rouleau, GW, Talbot, O, Ilkayeva, OR, George, T, et al.. Cord blood metabolites associated with newborn adiposity and hyperinsulinemia. J Pediatr 2018;203:144\u20139.e1. https:\/\/doi.org\/10.1016\/j.jpeds.2018.07.056.","DOI":"10.1016\/j.jpeds.2018.07.056"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_025_w2aab3b7c33b1b6b1ab2b2c25Aa","doi-asserted-by":"crossref","unstructured":"Yang, L, Zhang, Y, Yang, J, Huang, X. Effects of birth weight on profiles of dried blood amino-acids and acylcarnitines. Ann Clin Biochem 2018;55:92\u20139. https:\/\/doi.org\/10.1177\/0004563216688038.","DOI":"10.1177\/0004563216688038"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_026_w2aab3b7c33b1b6b1ab2b2c26Aa","doi-asserted-by":"crossref","unstructured":"De, T, Kruthika-Vinod, TP, Nagaraja, D, Christopher, R. Postnatal variations in blood free and acylcarnitines. J Clin Lab Anal 2011;25:126\u20139. https:\/\/doi.org\/10.1002\/jcla.20445.","DOI":"10.1002\/jcla.20445"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_027_w2aab3b7c33b1b6b1ab2b2c27Aa","doi-asserted-by":"crossref","unstructured":"Floris, LM, Stahl, B, Abrahamse-Berkeveld, M, Celler, IC. Human milk fatty acid profile across lactational stages after term and preterm delivery: a pooled data analysis. Prostaglandins Leukot Essent Fatty Acids 2019;16:102023. https:\/\/doi.org\/10.1016\/j.plefa.2019.102023.","DOI":"10.1016\/j.plefa.2019.102023"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_028_w2aab3b7c33b1b6b1ab2b2c28Aa","doi-asserted-by":"crossref","unstructured":"Vaz, FM, Melegh, B, Bene, J, Cuebas, D, Gage, DA, Bootsma, A, et al.. Analysis of carnitine biosynthesis metabolites in urine by HPLC-electrospray tandem mass spectrometry. Clin Chem 2002;48:826\u201334. https:\/\/doi.org\/10.1093\/clinchem\/48.6.826.","DOI":"10.1093\/clinchem\/48.6.826"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_029_w2aab3b7c33b1b6b1ab2b2c29Aa","doi-asserted-by":"crossref","unstructured":"Shenai, JP, Borum, PR. Tissue carnitine reserves of newborn infants. Pediatr Res 1984;18:679\u201382. https:\/\/doi.org\/10.1203\/00006450-198407000-00024.","DOI":"10.1203\/00006450-198407000-00024"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_030_w2aab3b7c33b1b6b1ab2b2c30Aa","doi-asserted-by":"crossref","unstructured":"Thodi, G, Georgiou, V, Molou, E, Loukas, YL, Dotsikas, Y, Biti, S, et al.. Characterization of the molecular spectrum of Medium-Chain Acyl-CoA Dehydrogenase Deficiency in a Greek newborns cohort: identification of a novel variant. Clin Biochem 2012;45:1167\u201372. https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.05.030.","DOI":"10.1016\/j.clinbiochem.2012.05.030"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_031_w2aab3b7c33b1b6b1ab2b2c31Aa","doi-asserted-by":"crossref","unstructured":"Merritt, JL2nd, Norris, M, Kanungo, S. Fatty acid oxidation disorders. Ann Transl Med 2018;6:473. https:\/\/doi.org\/10.21037\/atm.2018.10.57.","DOI":"10.21037\/atm.2018.10.57"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_032_w2aab3b7c33b1b6b1ab2b2c32Aa","doi-asserted-by":"crossref","unstructured":"Reda, E, D\u2019Iddio, S, Nicolai, R, Benatti, P, Calvani, M. The carnitine system and body composition. Acta Diabetol 2003;40:S106\u201313. https:\/\/doi.org\/10.1007\/s00592-003-0040-z.","DOI":"10.1007\/s00592-003-0040-z"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_033_w2aab3b7c33b1b6b1ab2b2c33Aa","doi-asserted-by":"crossref","unstructured":"Schellong, K, Schulz, S, Harder, T, Plagemann, A. Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PLoS One 2012;7:e47776. https:\/\/doi.org\/10.1371\/journal.pone.0047776.","DOI":"10.1371\/journal.pone.0047776"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_034_w2aab3b7c33b1b6b1ab2b2c34Aa","doi-asserted-by":"crossref","unstructured":"Wright, EL, Baker, PR. Neonatal macrosomia is an interfering factor for analytes on the Colorado state newborn screen. J Clin Endocrinol Metab 2020;105:e1561\u20138. https:\/\/doi.org\/10.1210\/clinem\/dgz183.","DOI":"10.1210\/clinem\/dgz183"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_035_w2aab3b7c33b1b6b1ab2b2c35Aa","doi-asserted-by":"crossref","unstructured":"Sanches-Pintos, P, de Castro, MJ, Roca, I, Rite, S, Lopez, M, Couce, ML. Similarities between acylcarnitine profiles in large for gestational age newborns and obesity. Sci Rep 2017;7:16267. https:\/\/doi.org\/10.1038\/s41598-017-15809-4.","DOI":"10.1038\/s41598-017-15809-4"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_036_w2aab3b7c33b1b6b1ab2b2c36Aa","doi-asserted-by":"crossref","unstructured":"Mai, M, T\u00f6njes, A, Kovacs, P, Stumvoll, M, Fiedler, GM, Leichte, AB. Serum levels of acylcarnitines are altered in prediabetics conditions. PLoS One 2013;8:e82459. https:\/\/doi.org\/10.1371\/journal.pone.0082459.","DOI":"10.1371\/journal.pone.0082459"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_037_w2aab3b7c33b1b6b1ab2b2c37Aa","doi-asserted-by":"crossref","unstructured":"Yoon, HR. Screening newborns for metabolic disorders based on targeted metabolomics using tandem mass spectrometry. Ann Pediatr Endocrinol Metab 2015;20:119\u201324. https:\/\/doi.org\/10.6065\/apem.2015.20.3.119.","DOI":"10.6065\/apem.2015.20.3.119"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_038_w2aab3b7c33b1b6b1ab2b2c38Aa","doi-asserted-by":"crossref","unstructured":"Waisbren, SE, Landau, Y, Wilson, J, Vockley, J. Neuropsychological outcomes in fatty acid oxidation disorders: 85 cases detected by newborn screening. Dev Disabil Res Rev 2013;17:260\u20138. https:\/\/doi.org\/10.1002\/ddrr.1119.","DOI":"10.1002\/ddrr.1119"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_039_w2aab3b7c33b1b6b1ab2b2c39Aa","doi-asserted-by":"crossref","unstructured":"Barker, DJ. The fetal and infant origins of adult disease. BMJ 1990;301:1111. https:\/\/doi.org\/10.1136\/bmj.301.6761.1111.","DOI":"10.1136\/bmj.301.6761.1111"},{"key":"2023040101170325399_j_jpem-2020-0741_ref_040_w2aab3b7c33b1b6b1ab2b2c40Aa","doi-asserted-by":"crossref","unstructured":"Manta-Vogli, PD, Schulpis, KH, Dotsikas, Y, Loukas, YL. The significant role of amino acids during pregnancy: nutritional support. J Matern Fetal Neonatal Med 2020;33:334\u201340. https:\/\/doi.org\/10.1080\/14767058.2018.1489795.","DOI":"10.1080\/14767058.2018.1489795"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0741\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0741\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T19:10:47Z","timestamp":1680376247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2020-0741\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,24]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,6,14]]},"published-print":{"date-parts":[[2021,8,26]]}},"alternative-id":["10.1515\/jpem-2020-0741"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2020-0741","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,24]]}}}