{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:09:46Z","timestamp":1787022586433,"version":"build-2736575974"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2021-0035_abs_001_w2aab3b7c37b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hashimoto\u2019s thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children and adolescents, especially in areas without endemic iodine deficiency. We aimed to evaluate the follow-up results of children and adolescents diagnosed with HT, including clinical, biochemical, and radiological findings and treatment approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2021-0035_abs_003_w2aab3b7c37b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HT patients, who were diagnosed between 2012 and 2018 years in a single-center, were assessed retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2021-0035_abs_004_w2aab3b7c37b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred and twenty-four cases were included in the study, 75.9% of whom were girls (female\/male ratio: 3.1) and 66.5% were pubertal. The median age of the cases at first admission was 12.5 (9.2\u201315) years. The median follow-up period of 196 patients, who continued their follow-up regularly, was 2.1 (0.7\u20134.8) years. When autoantibody levels were analyzed according to gender, mean anti-Tg levels were higher in girls (p=0.028), whereas anti-TPO levels were similar (p=0.372). A nodule was detected in the ultrasonographic follow-up of 29 (13%) patients. Papillary thyroid carcinoma was observed in 10.3% (n=3) of those with nodules. When the last ultrasonography findings of 188 patients with available radiological follow-up data were compared with their initial evaluation, the rate of\u00a0heterogeneous parenchymal echogenicity increased significantly (p=0.008). The need for\n                      <jats:sc>l<\/jats:sc>\n                      -thyroxine dosage augmented over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2021-0035_abs_005_w2aab3b7c37b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although HT is more common in adolescent girls, it can be encountered in both genders and at all ages in childhood. The incidence of malignancy was not higher in patients with nodules associated with HT than the reported incidences of malignancy in nodules not associated with HT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2021-0035","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T18:07:01Z","timestamp":1623694021000},"page":"987-994","source":"Crossref","is-referenced-by-count":8,"title":["Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto\u2019s thyroiditis: a single-center experience"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-979X","authenticated-orcid":false,"given":"\u0130rem Ceren","family":"Erba\u015f","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Faculty of Medicine, \u0130stanbul University\u00a0\u2013 Cerrahpa\u015fa , \u0130stanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-8868","authenticated-orcid":false,"given":"\u0130brahim Mert","family":"Erba\u015f","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Faculty of Medicine, Dokuz Eyl\u00fcl University , \u0130zmir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-8637","authenticated-orcid":false,"given":"Olcay","family":"Evliyao\u011flu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Faculty of Medicine, \u0130stanbul University\u00a0\u2013 Cerrahpa\u015fa , \u0130stanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"2023040101170331767_j_jpem-2021-0035_ref_001_w2aab3b7c37b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Vanderpump, MP, Tunbridge, WM, French, JM. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 1995;43:55\u201368.","DOI":"10.1111\/j.1365-2265.1995.tb01894.x"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_002_w2aab3b7c37b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"De Luca, F, Santucci, S, Corica, D, Pitrolo, E, Romeo, M, Aversa, T. Hashimoto\u2019s thyroiditis in childhood: presentation modes and evolution over time. Ital J Pediatr 2013;39:8.","DOI":"10.1186\/1824-7288-39-8"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_003_w2aab3b7c37b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Pasala, P, Francis, G. Autoimmune thyroid diseases in children. Expet Rev Endocrinol Metabol 2017;12:129\u201342.","DOI":"10.1080\/17446651.2017.1300525"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_004_w2aab3b7c37b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Fava, A, Oliverio, R, Giuliano, S, Parlato, G, Michniewicz, A, Indrieri, A, et al.. Clinical evolution of autoimmune thyroiditis in children and adolescents. Thyroid 2009;19:361\u20137.","DOI":"10.1089\/thy.2008.0239"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_005_w2aab3b7c37b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Cappa, M, Bizzarri, C, Crea, F. Autoimmune thyroid diseases in children. J Thyroid Res 2010;2011:675703.","DOI":"10.4061\/2011\/675703"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_006_w2aab3b7c37b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Demir, K, Konak\u00e7\u0131, E, \u00d6zkaya, G, Kasap Demir, B, \u00d6zen, S, Ayd\u0131n, M, et al.. New features for Child Metrics: further growth references and blood pressure calculations. J Clin Res Pediatr Endocrinol 2020;12:125\u20139.","DOI":"10.4274\/jcrpe.galenos.2019.2019.0127"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_007_w2aab3b7c37b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Neyzi, O, Bundak, R, G\u00f6k\u00e7ay, G, G\u00fcn\u00f6z, H, Furman, A, Darendeliler, F, et al.. Reference values for weight, height, head circumference, and body mass index in Turkish children. J Clin Res Pediatr Endocrinol 2015;7:280\u201393.","DOI":"10.4274\/jcrpe.2183"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_008_w2aab3b7c37b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Tanner, JM, Whitehouse, RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976;51:170\u20139.","DOI":"10.1136\/adc.51.3.170"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_009_w2aab3b7c37b1b6b1ab2b1b9Aa","unstructured":"WHO. ICCIDD. Assessment of Iodine Deficiency Disorders and Monitoring their Elimination: a Guide for Programme Managers, 2nd ed. Geneva: WHO\/NHD; 2001."},{"key":"2023040101170331767_j_jpem-2021-0035_ref_010_w2aab3b7c37b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Tas, F, Bulut, S, Egilmez, H, Oztoprak, I, Ergur, AT, Candan, F. Normal thyroid volume by ultrasonography in healthy children. Ann Trop Paediatr 2002;22:375\u20139.","DOI":"10.1179\/027249302125002047"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_011_w2aab3b7c37b1b6b1ab2b1c11Aa","unstructured":"Recommended normative values for thyroid volume in children aged 6\u201315 years. World Health Organization & International Council for Control of Iodine Deficiency Disorders. Bull World Health Organ 1997;75:95\u20137."},{"key":"2023040101170331767_j_jpem-2021-0035_ref_012_w2aab3b7c37b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Cibas, ES, Ali, SZ. The Bethesda system for reporting thyroid cytopathology. Thyroid 2009;19:1159\u201365.","DOI":"10.1089\/thy.2009.0274"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_013_w2aab3b7c37b1b6b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Caturegli, P, De Remigis, A, Rose, NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev 2014;13:391\u20137.","DOI":"10.1016\/j.autrev.2014.01.007"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_014_w2aab3b7c37b1b6b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Demirbilek, H, Kandemir, N, Gonc, EN, Ozon, A, Alika\u015fifo\u011flu, A, Yordam, N. Hashimoto\u2019s thyroiditis in children and adolescents: a retrospective study on clinical, epidemiological and laboratory properties of the disease. J Pediatr Endocrinol Metab 2007;20:1199\u2013205.","DOI":"10.1515\/JPEM.2007.20.11.1199"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_015_w2aab3b7c37b1b6b1ab2b1c15Aa","unstructured":"Ye\u015filkaya, E, Belen, B, Bideci, A, \u00c7amurdan, O, Boyraz, M, Cinaz, P. Kronik otoimm\u00fcn tiroiditli \u00e7ocuk ve ergenlerin klinik \u00f6zellikleri. G\u00fclhane T\u0131p Dergisi 2008;50:147\u201350."},{"key":"2023040101170331767_j_jpem-2021-0035_ref_016_w2aab3b7c37b1b6b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"de Vries, L, Phillip, M. Chronic autoimmune thyroiditis in children and adolescents: at presentation and during long-term follow-up. Arch Dis Child 2009;94:33\u20137.","DOI":"10.1136\/adc.2007.134841"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_017_w2aab3b7c37b1b6b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Do\u011fan, M, Acikgoz, E, Acikgoz, M, Cesur, Y, Ariyuca, S, Bektas, MS. The frequency of Hashimoto thyroiditis in children and the relationship between urinary iodine level and Hashimoto thyroiditis. J Pediatr Endocrinol Metab 2011;24:75\u201380.","DOI":"10.1515\/jpem.2011.115"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_018_w2aab3b7c37b1b6b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Evliyaoglu, O, Berberoglu, M, Adiyaman, P, Aycan, Z, Ergur, A, Siklar, Z, et al.. Incidence of iodine deficiency in patients presenting with goiter-discrepancy between clinical and ultrasonographic evaluation of the thyroid: comparison of patients with and without autoimmune thyroiditis\u00a0\u2013 clinical, hormonal and urinary iodine excretion studies. J Pediatr Endocrinol Metab 2006;19:39\u201344.","DOI":"10.1515\/JPEM.2006.19.1.39"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_019_w2aab3b7c37b1b6b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Tuhan, H, I\u015f\u0131k, S, Abac\u0131, A, \u015eim\u015fek, E, An\u0131k, A, Anal, \u00d6, et al.. Celiac disease in children and adolescents with Hashimoto Thyroiditis. Turk Pediatri Ars 2016;51:100\u20135.","DOI":"10.5152\/TurkPediatriArs.2016.3566"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_020_w2aab3b7c37b1b6b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Radetti, G, Loche, S, D\u2019Antonio, V, Salerno, M, Guzzetti, C, Aversa, T, et al.. Influence of Hashimoto thyroiditis on the development of thyroid nodules and cancer in children and adolescents. J Endocr Soc 2019;3:607\u201316.","DOI":"10.1210\/js.2018-00287"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_021_w2aab3b7c37b1b6b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Dundar, B, Boyac\u0131, A, Sar\u0131g\u00fcn, \u00d6, D\u00fcndar, N. Hashimoto thyroiditis in children and adolescents: evaluation of clinical and laboratory findings. Turk Pediatri Ars 2011;46:318\u201322.","DOI":"10.4274\/tpa.358.1338"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_022_w2aab3b7c37b1b6b1ab2b1c22Aa","doi-asserted-by":"crossref","unstructured":"Ozen, S, Berk, O, Simsek, DG, Darcan, S. Clinical course of Hashimoto\u2019s thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. J Clin Res Pediatr Endocrinol 2011;3:192\u20137.","DOI":"10.4274\/jcrpe.425"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_023_w2aab3b7c37b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"Wasniewska, M, Corrias, A, Salerno, M, Mussa, A, Capalbo, D, Messina, MF, et al.. Thyroid function patterns at Hashimoto\u2019s thyroiditis presentation in childhood and adolescence are mainly conditioned by patients\u2019 age. Horm Res Paediatr 2012;78:232\u20136.","DOI":"10.1159\/000343815"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_024_w2aab3b7c37b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Zak, T, Noczy\u0144ska, A, Wasikowa, R, Zaleska-Dorobisz, U, Golenko, A. Chronic autoimmune thyroid disease in children and adolescents in the years 1999\u20132004 in Lower Silesia, Poland. Hormones 2005;4:45\u20138.","DOI":"10.14310\/horm.2002.11142"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_025_w2aab3b7c37b1b6b1ab2b1c25Aa","unstructured":"Kaya, T, Varim, C, Nalbant, A, Gunduz, Y, Tamer, A. Ultrasonographic findings of thyroid in patients with Hashimoto thyroiditis: overt hypothyroid and euthyroid. Med Glas 2013;10:343\u20137."},{"key":"2023040101170331767_j_jpem-2021-0035_ref_026_w2aab3b7c37b1b6b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"Langer, JE, Khan, A, Nisenbaum, HL, Baloch, ZW, Horii, SC, Coleman, BG, et al.. Sonographic appearance of focal thyroiditis. AJR Am J Roentgenol 2001;176:751\u20134.","DOI":"10.2214\/ajr.176.3.1760751"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_027_w2aab3b7c37b1b6b1ab2b1c27Aa","doi-asserted-by":"crossref","unstructured":"Dilek, E, Iscan, B, Ekuklu, G, Tutunculer, F. A retrospective evaluation of the cases diagnosed as Hashimoto\u2019s thyroiditis. J Child 2011;11:73\u20137.","DOI":"10.5222\/j.child.2011.073"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_028_w2aab3b7c37b1b6b1ab2b1c28Aa","doi-asserted-by":"crossref","unstructured":"G\u00f3mez L\u00f3pez, E, Nso-Roca, AP, Juste Ruiz, M, Cort\u00e9s Castell, E. Hashimoto\u2019s disease in a cohort of 29 children and adolescents. Epidemiology, clinical course, and comorbidities in the short and long term. Arch Argent Pediatr 2018;116:56\u20138.","DOI":"10.5546\/aap.2018.eng.56"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_029_w2aab3b7c37b1b6b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Dorr, HG, Bettendorf, M, Binder, G, Karges, B, Kneppo, C, Schmidt, H, et al.. Levothyroxine treatment of euthyroid children with autoimmune Hashimoto thyroiditis: results of a multicenter, randomized, controlled trial. Horm Res Paediatr 2015;84:266\u201374.","DOI":"10.1159\/000437140"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_030_w2aab3b7c37b1b6b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"Ibili, ABP, Selver Eklioglu, B, Atabek, ME. General properties of autoimmune thyroid diseases and associated morbidities. J Pediatr Endocrinol Metab 2020;33:509\u201315.","DOI":"10.1515\/jpem-2019-0331"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_031_w2aab3b7c37b1b6b1ab2b1c31Aa","unstructured":"Legakis, I, Manousaki, M, Detsi, S, Nikita, D. Thyroid function and prevalence of anti-thyroperoxidase (TPO) and anti-thyroglobulin (Tg) antibodies in outpatients hospital setting in an area with sufficient iodine intake: influences of age and sex. Acta Med Iran 2013;51:25\u201334."},{"key":"2023040101170331767_j_jpem-2021-0035_ref_032_w2aab3b7c37b1b6b1ab2b1c32Aa","doi-asserted-by":"crossref","unstructured":"Hollowell, JG, Staehling, NW, Flanders, WD, Hannon, WH, Gunter, EW, Spencer, CA, et al.. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489\u201399.","DOI":"10.1210\/jcem.87.2.8182"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_033_w2aab3b7c37b1b6b1ab2b1c33Aa","doi-asserted-by":"crossref","unstructured":"Doeker, B, Reinehr, T, Andler, W. Autoimmune thyroiditis in children and adolescents: clinical and laboratory findings in 34 patients. Klin P\u00e4diatr 2000;212:103\u20137.","DOI":"10.1055\/s-2000-9661"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_034_w2aab3b7c37b1b6b1ab2b1c34Aa","doi-asserted-by":"crossref","unstructured":"Won, JH, Lee, JY, Hong, HS, Jeong, SH. Thyroid nodules and cancer in children and adolescents affected by Hashimoto\u2019s thyroiditis. Br J Radiol 2018;91:20180014.","DOI":"10.1259\/bjr.20180014"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_035_w2aab3b7c37b1b6b1ab2b1c35Aa","doi-asserted-by":"crossref","unstructured":"Popoveniuc, G, Jonklaas, J. Thyroid nodules. Med Clin North Am 2012;96:329\u201349.","DOI":"10.1016\/j.mcna.2012.02.002"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_036_w2aab3b7c37b1b6b1ab2b1c36Aa","doi-asserted-by":"crossref","unstructured":"Filipovi\u00e7, A, Paunovi\u00e7, I, Vuckovi\u00e7, L. Influence of lymphocytic thyroiditis on prognostic outcome differentiated thyroid carcinoma. Acta Chir Iugosl 2010;57:85\u201394.","DOI":"10.2298\/ACI1002085F"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_037_w2aab3b7c37b1b6b1ab2b1c37Aa","doi-asserted-by":"crossref","unstructured":"Sur, ML, Gaga, R, Laz\u0103r, C, Lazea, C, Aldea, C, Sur, D. Papillary thyroid carcinoma in children with Hashimoto\u2019s thyroiditis\u00a0\u2013 a review of the literature between 2000 and 2020. J Pediatr Endocrinol Metab 2020;33:1511\u20137.","DOI":"10.1515\/jpem-2020-0383"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_038_w2aab3b7c37b1b6b1ab2b1c38Aa","doi-asserted-by":"crossref","unstructured":"Francis, GL, Waguespack, SG, Bauer, AJ, Angelos, P, Benvenga, S, Cerutti, JM, et al.. American thyroid association guidelines task force. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid 2015;25:716\u201359.","DOI":"10.1089\/thy.2014.0460"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_039_w2aab3b7c37b1b6b1ab2b1c39Aa","doi-asserted-by":"crossref","unstructured":"Rotondi, M, Groppelli, G, Croce, L, Latrofa, F, Ancona, G, Coperchini, F, et al.. Patients with chronic autoimmune thyroiditis are not at higher risk for developing clinically overt thyroid cancer: a 10-year follow-up study. Eur J Endocrinol 2020;183:317\u201323.","DOI":"10.1530\/EJE-20-0350"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_040_w2aab3b7c37b1b6b1ab2b1c40Aa","doi-asserted-by":"crossref","unstructured":"Guille, JT, Opoku-Boateng, A, Thibeault, SL, Chen, H. Evaluation and management of the pediatric thyroid nodule. Oncol 2015;20:19\u201327.","DOI":"10.1634\/theoncologist.2014-0115"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_041_w2aab3b7c37b1b6b1ab2b1c41Aa","doi-asserted-by":"crossref","unstructured":"Shimura, H, Sobue, T, Takahashi, H, Yasumura, S, Ohira, T, Ohtsuru, A, et al.. Thyroid examination unit of the radiation medical center for the Fukushima Health Management Survey group. Findings of thyroid ultrasound examination within 3 years after the Fukushima nuclear power plant accident: the Fukushima Health Management Survey. J Clin Endocrinol Metab 2018;103:861\u20139.","DOI":"10.1210\/jc.2017-01603"},{"key":"2023040101170331767_j_jpem-2021-0035_ref_042_w2aab3b7c37b1b6b1ab2b1c42Aa","doi-asserted-by":"crossref","unstructured":"Paulson, VA, Rudzinski, ER, Hawkins, DS. Thyroid cancer in the pediatric population. Genes 2019;10:723.","DOI":"10.3390\/genes10090723"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0035\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0035\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T15:14:36Z","timestamp":1680362076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0035\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,6,14]]},"published-print":{"date-parts":[[2021,8,26]]}},"alternative-id":["10.1515\/jpem-2021-0035"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2021-0035","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,15]]}}}