{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:56:44Z","timestamp":1790632604864,"version":"4.1.0"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0087_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>\u00a0Laron syndrome (LS) is a disease caused by growth hormone receptor (GHR) defects. It is characterized by severe postnatal growth retardation and distinctive facial features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0087_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>In this case report, we describe the clinical and biochemical characteristics of two siblings with LS, a sister and a brother, and identify a homozygous c.344A&gt; C (p.Asn115Thr) variant in GHR. The sister was 11 years 9 months old with a height of 127.5 cm (-3.86 SDS), and the brother was 14 years 10 months old with a height of 139 cm (-4.27 SDS). Their phenotype did not have features suggesting classical LS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0087_abs_003\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In the current literature, there are three cases with the same missense variant. Our cases differ from them in clinical (higher height SDS, mild dysmorphism including a broad forehead, malar hypoplasia, prominent columella and chin, thick lips) and biochemical characteristics. Here, we present the variable expressivity in the two siblings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0044","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T09:01:26Z","timestamp":1625389286000},"page":"1349-1354","source":"Crossref","is-referenced-by-count":1,"title":["Mild phenotype in two siblings with a missense GHR variant"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-3038","authenticated-orcid":false,"given":"Behiye","family":"Sar\u0131kaya \u00d6zdemir","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Department , Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital, University of Health Sciences Turkey , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3974-2872","authenticated-orcid":false,"given":"Semra","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department , Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital, University of Health Sciences Turkey , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-371X","authenticated-orcid":false,"given":"Naz","family":"G\u00fcleray Lafc\u0131","sequence":"additional","affiliation":[{"name":"Medical Genetics Department , Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital,University of Health Sciences Turkey , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4960-6092","authenticated-orcid":false,"given":"Merve","family":"\u015eakar","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department , Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital, University of Health Sciences Turkey , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-1711","authenticated-orcid":false,"given":"G\u00fclin","family":"Karacan K\u00fc\u00e7\u00fckali","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department , Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital, University of Health Sciences Turkey , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-7859","authenticated-orcid":false,"given":"Selin","family":"Elmao\u011fullari","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department , Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital, University of Health Sciences Turkey , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-5089","authenticated-orcid":false,"given":"\u015eenay","family":"Sava\u015f Erdeve","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department , Dr. Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease Training and Research Hospital, University of Health Sciences Turkey , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"2023040101125223192_j_jpem-2021-0044_ref_001","doi-asserted-by":"crossref","unstructured":"Kurto\u011flu, S, Hatipoglu, N. Growth hormone insensitivity: diagnostic and therapeutic approaches. J Endocrinol Invest 2016;39:19\u201328.","DOI":"10.1007\/s40618-015-0327-2"},{"key":"2023040101125223192_j_jpem-2021-0044_ref_002","doi-asserted-by":"crossref","unstructured":"Lin, S, Li, C, Li, C, Zhang, X. Growth hormone receptor mutations related to individual dwarfism. Int J Mol Sci 2018;19:1433. https:\/\/doi.org\/10.3390\/ijms19051433.","DOI":"10.3390\/ijms19051433"},{"key":"2023040101125223192_j_jpem-2021-0044_ref_003","doi-asserted-by":"crossref","unstructured":"David, A, Hwa, V, Metherell, LA, Netchine, I, Camacho-H\u00fcbner, C, Clark, AJ, et al.. Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity. Endocr Rev 2011;32:472\u201397. https:\/\/doi.org\/10.1210\/er.2010-0023.","DOI":"10.1210\/er.2010-0023"},{"key":"2023040101125223192_j_jpem-2021-0044_ref_004","doi-asserted-by":"crossref","unstructured":"Woods, KA, Savage, MO. 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