{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:03:53Z","timestamp":1790262233689,"version":"4.1.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0051_abs_001_w2aab3b7c61b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>It is unclear whether body weight status (underweight\/normal weight\/overweight\/obese) is associated with allergic disease. Our objective was to investigate the relationship between body weight status (body mass index; BMI) and atopic allergic disease in prepubertal children, and to compare children with atopic allergic diseases with non atopic healthy children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0051_abs_002_w2aab3b7c61b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective cross sectional study of 707 prepubertal children aged 3\u201310 years was performed; the participants were 278 atopic children with physician-diagnosed allergic disease (allergic rhinitis and asthma) (serum total IgE level &gt;100\u00a0kU\/l and eosinophilia &gt;4%, or positivity to at least one allergen in skin test) and 429 non atopic healthy age- and sex-matched controls. Data were collected between December 2019 and November 2020 at the Pediatric General and Pediatric Allergy Outpatient Clinics of Bezmialem Vak\u0131f University Hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0051_abs_003_w2aab3b7c61b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Underweight was observed in 11.6% of all participants (10.8% of atopic children, 12.2% of healthy controls), and obesity in 14.9% of all participants (18.0% of atopic children, 12.8% of controls). Obese (OR 1.71; 95% CI: 1.08\u20132.71, p=0.021), and overweight status (OR 1.62; 95% CI: 1.06\u20132.50, p=0.026) were associated with an increased risk of atopic allergic disease compared to normal weight in\u00a0pre-pubertal children. This association did not differ by\u00a0gender. There was no relationship between underweight status and atopic allergic disease (OR 1.03; 95% CI: 0.63\u20131.68, p=0.894).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0051_abs_004_w2aab3b7c61b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overweight and obesity were associated with an increased risk of atopic allergic disease compared to normal weight among middle-income and high-income pre pubertal children living in Istanbul.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0051","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T22:38:59Z","timestamp":1617835139000},"page":"727-732","source":"Crossref","is-referenced-by-count":17,"title":["Is overweight\/obesity a risk factor for atopic allergic disease in prepubertal children? A case\u2013control study"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-6330","authenticated-orcid":false,"given":"Aysel","family":"Vehapoglu","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Bezmialem Vak\u0131f University, Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-5878","authenticated-orcid":false,"given":"Zeynep Ebru","family":"Cak\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Bezmialem Vak\u0131f University, Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-7723","authenticated-orcid":false,"given":"Feyza Ustabas","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Bezmialem Vak\u0131f University, Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-1082","authenticated-orcid":false,"given":"Mustafa Atilla","family":"Nursoy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology , Bezmialem Vak\u0131f University, Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-2790","authenticated-orcid":false,"given":"Ali","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Statistics , Faculty of Medicine, Bezmialem Vakif University , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"2023040101193742299_j_jpem-2021-0051_ref_001_w2aab3b7c61b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Tajima, H, Pawankar, R. 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