{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:40Z","timestamp":1747198240278,"version":"3.40.5"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0094_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the case of a 12-year-old girl with a rare plurihormonal pituitary macroadenoma secreting prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), and alpha subunit (\u03b1-SU).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0094_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>The patient experienced recurrent headaches and progressing loss of vision in one eye. During the examination, abnormalities such as tall stature, coarse facial features, enlarged feet and hands, tachycardia, hand tremor, hyperhidrosis, galactorrhea, and goiter were observed. Head magnetic resonance imaging (MRI) revealed a solid tumor in the anterior and middle cranial fossa, measuring 80 \u00d7 50 \u00d7 55 mm. A stereotactic biopsy revealed plurihormonal Pit-1 positive pituitary adenoma secreting PRL, GH, and TSH. A pituitary hyperfunction with PRL, GH, TSH, and \u03b1-SU excess was diagnosed. The patient was successfully treated pharmacologically with dopamine agonists and somatostatin analogue, and a decrease of tumor volume (30%) was achieved.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0094_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>When neurosurgery is not possible, long-term pharmacological treatment of plurihormonal pituitary macroadenoma can be a safe and relatively effective alternative.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0094","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T22:09:19Z","timestamp":1626818959000},"page":"1469-1473","source":"Crossref","is-referenced-by-count":1,"title":["Giant plurihormonal pituitary adenoma in a child\u00a0\u2013 case study"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-7003","authenticated-orcid":false,"given":"El\u017cbieta","family":"Moszczy\u0144ska","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetology , Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-5781","authenticated-orcid":false,"given":"Wies\u0142awa","family":"Grajkowska","sequence":"additional","affiliation":[{"name":"Department of Pathology , Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6806-6079","authenticated-orcid":false,"given":"Maria","family":"Maksymowicz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Diagnostics , Maria Sklodowska\u00a0\u2013 Curie National Research Institute of Oncology , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-9828","authenticated-orcid":false,"given":"Joanna","family":"Malicka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Medical University of\u00a0Lublin , Lublin , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-761X","authenticated-orcid":false,"given":"Mieczys\u0142aw","family":"Szalecki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology , Children\u2019s Memorial Health Institute , Warsaw , Poland"},{"name":"The Faculty of Medicine and Health Sciences, Jan Kochanowski University , Kielce , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-6784","authenticated-orcid":false,"given":"Monika","family":"Prokop-Piotrkowska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology , Children\u2019s Memorial Health Institute , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"2023040101375949817_j_jpem-2021-0094_ref_001","doi-asserted-by":"crossref","unstructured":"Keil, MF, Stratakis, CA. Pituitary tumors in childhood: an update in their diagnosis, treatment and molecular genetics. Expert Rev Neurother 2008;8:563\u201374. https:\/\/doi.org\/10.1586\/14737175.8.4.563.","DOI":"10.1586\/14737175.8.4.563"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_002","doi-asserted-by":"crossref","unstructured":"Gulbadin, D, Li, Z, Shahbaz, M, Farhaj, Z, Shabbir, A, Qi, Q, et al.. Patients with true mixed growth hormone and prolactin-secreting pituitary adenoma: a case series of 12 patients. Br J Neurosurg 2020;34:154\u201360. https:\/\/doi.org\/10.1080\/02688697.2020.1713989.","DOI":"10.1080\/02688697.2020.1713989"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_003","doi-asserted-by":"crossref","unstructured":"Beatriz, M, Lopes, S. The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol 2017;134:521\u201335.","DOI":"10.1007\/s00401-017-1769-8"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_004","doi-asserted-by":"crossref","unstructured":"De Menis, E, Visentin, A, Billeci, D, Tramontin, P, Agostini, S, Marton, E, et al.. Pituitary adenomas in childhood and adolescence. Clinical analysis of 10 cases. J Endocrinol Invest 2001;24:92\u20137. https:\/\/doi.org\/10.1007\/BF03343820.","DOI":"10.1007\/BF03343820"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_005","doi-asserted-by":"crossref","unstructured":"Perry, A, Graffeo, CS, Marcellino, C, Pollock, BE, Wetjen, NM, Meyer, FB. Pediatric pituitary adenoma: case series, review of the literature, and a skull base treatment paradigm. J Neurol Surg Part B Skull Base 2018;79:91\u2013114. https:\/\/doi.org\/10.1055\/s-0038-1625984.","DOI":"10.1055\/s-0038-1625984"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_006","doi-asserted-by":"crossref","unstructured":"Asa, SL, Casar-Borota, O, Chanson, P, Delgrange, E, Earls, P, Ezzat, S, et al.. From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal. Endocr Relat Canc 2017;24:C5\u20138. https:\/\/doi.org\/10.1530\/ERC-17-0004.","DOI":"10.1530\/ERC-17-0004"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_007","doi-asserted-by":"crossref","unstructured":"Ho, K, Fleseriu, M, Kaiser, U, Salvatori, M, Brue, T, Lopes, MB, et al.. Pituitary neoplasm nomenclature workshop: does adenoma stand the test of time? J Endocr Soc 2021;5:bvaa205. https:\/\/doi.org\/10.1210\/jendso\/bvaa205.","DOI":"10.1210\/jendso\/bvaa205"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_008","doi-asserted-by":"crossref","unstructured":"Dyer, EH, Civit, T, Viscot, A, Delalande, O, Derome, P. Transfenoidal surgery for pituitary adenomas in children. Neurosurgery 1994;34:201\u201312.","DOI":"10.1097\/00006123-199402000-00001"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_009","doi-asserted-by":"crossref","unstructured":"Capozzi, A, Scambia, G, Pontecorvi, A, Lello, S. Hyperprolactinemia: pathophysiology and therapeutic approach. Gynecol Endocrinol 2015;31:506\u201310. https:\/\/doi.org\/10.3109\/09513590.2015.1017810.","DOI":"10.3109\/09513590.2015.1017810"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_010","doi-asserted-by":"crossref","unstructured":"Sethi, A, Didi, M, Dharmaraj, P, Ramakrishnan, R, Senniappan, S, Das, U, et al.. Obesity is common at diagnosis of childhood pituitary adenoma and may persist following successful treatment. Clin Endocrinol (Oxf) 2020;92:323\u201330. https:\/\/doi.org\/10.1111\/cen.14146.","DOI":"10.1111\/cen.14146"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_011","doi-asserted-by":"crossref","unstructured":"Dos Santos Silva, CM, Barbosa, FRP, Lima, GAB, Warszawski, L, Fontes, R, Domingues, RC, et al.. BMI and metabolic profile in patients with prolactinoma before and after treatment with dopamine agonists. Obesity (Silver Spring) 2011;19:800\u20135. https:\/\/doi.org\/10.1038\/oby.2010.150.","DOI":"10.1038\/oby.2010.150"},{"key":"2023040101375949817_j_jpem-2021-0094_ref_012","doi-asserted-by":"crossref","unstructured":"Daly, AF, Tichomirowa, MA, Beckers, A. Genetic, molecular and clinical features of familial isolated pituitary adenomas. Horm Res 2009;71:116\u201322. https:\/\/doi.org\/10.1159\/000192448.","DOI":"10.1159\/000192448"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0094\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0094\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T21:12:46Z","timestamp":1680383566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0094\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,8,6]]},"published-print":{"date-parts":[[2021,11,25]]}},"alternative-id":["10.1515\/jpem-2021-0094"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2021-0094","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"type":"print","value":"0334-018X"},{"type":"electronic","value":"2191-0251"}],"subject":[],"published":{"date-parts":[[2021,7,21]]}}}