{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:42:34Z","timestamp":1762508554311,"version":"3.37.3"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"10","funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals Incubating Program","doi-asserted-by":"publisher","award":["(PX2020055)"],"award-info":[{"award-number":["(PX2020055)"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0137_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The use of inhibin B (INHB), anti-M\u00fcllerian hormone (AMH) and insulin-like growth factor-1 (IGF-1) in\u00a0differentiating central precocious puberty (CPP) from non-CPP was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0137_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 115 Chinese girls were recruited (CPP: 44, non-CPP: 71). The diagnostic performance of INHB, AMH and IGF-1 in differentiating CPP from non-CPP was analyzed using receiver operating characteristic (ROC) curves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0137_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>INHB levels were higher in the CPP group than in the non-CPP group (55.56\u00a0\u00b1\u00a022.42 vs. 32.97\u00a0\u00b1\u00a015.59\u00a0pg\/mL; p&lt;0.001). AMH levels were similar in the CPP and non-CPP groups (6.63\u00a0\u00b1\u00a03.74 vs. 5.70\u00a0\u00b1\u00a03.15\u00a0pg\/mL; p=0.158), and IGF-1 levels were much higher in the CPP group than in the non-CPP group (290.75\u00a0\u00b1\u00a079.78 vs. 200.10\u00a0\u00b1\u00a054.01\u00a0pg\/mL; p&lt;0.001). The area under the ROC curve (AUC) was greatest for INHB (0.819, standard error (SE) 0.041), followed by IGF-1 (0.809, SE 0.047) and AMH (0.567, SE 0.057). Among the ROC curves including combinations of these parameters, the AUC for INHB\u00a0+\u00a0IGF-1 was 0.849 and that for INHB\u00a0+\u00a0AMH was 0.768.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0137_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Serum INHB and IGF-1 measurements could predict positive responses to gonadotropin-releasing hormone (GnRH) analog stimulation in girls with precocious puberty.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0137","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T01:57:32Z","timestamp":1626919052000},"page":"1257-1262","source":"Crossref","is-referenced-by-count":8,"title":["The utility of serum inhibin B, anti-M\u00fcllerian hormone and insulin growth factor-1 in predicting a positive response to GnRH analogs for diagnosing central precocious puberty in girls"],"prefix":"10.1515","volume":"34","author":[{"given":"Liu","family":"Ziqin","sequence":"first","affiliation":[{"name":"Department of Endocrinology , Capital Institute of Pediatrics , Beijing , P. R. China"},{"name":"Peking Union Medical College Graduate School , Beijing , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Qinwei","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory , Capital Institute of Pediatrics , Beijing , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Xiaobo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Capital Institute of Pediatrics , Beijing , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xiaohui","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Graduate School , Beijing , P. R. China"},{"name":"Department of Cardiology , Capital Institute of Pediatrics , Beijing , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"2023040101125232473_j_jpem-2021-0137_ref_001","doi-asserted-by":"crossref","unstructured":"Carel, JC, L\u00e9ger, J. Clinical practice. Precocious puberty. N Engl J Med 2008;358:2366\u201377. https:\/\/doi.org\/10.1056\/nejmcp0800459.","DOI":"10.1056\/NEJMcp0800459"},{"key":"2023040101125232473_j_jpem-2021-0137_ref_002","doi-asserted-by":"crossref","unstructured":"Parent, AS, Teilmann, G, Juul, A, Skakkebaek, NE, Toppari, J, Bourguignon, JP. The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. 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