{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:57:09Z","timestamp":1778641029001,"version":"3.51.4"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0160_abs_001_w2aab3b7c40b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Premature adrenarche may be associated with an intrauterine programmed metabolic syndrome which should be considered as a warning sign for coronary heart disease due to accelerated atherosclerosis, hypertension, type 2 diabetes mellitus (DM), and polycystic ovary syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0160_abs_002_w2aab3b7c40b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seventy-three patients with premature adrenarche were evaluated for metabolic parameters and aortic elasticity to evaluate the susceptibility to atherosclerosis and compared with a control group. The patients were examined in two groups as overweight and nonoverweight, and metabolic and cardiac parameters were also compared among these groups. Strain, distensibility, and stiffness index parameters were used to evaluate aortic elasticity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0160_abs_003_w2aab3b7c40b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Biochemical parameters and cardiac measurements were not statistically different between patients and controls. They also did not differ between patients with normal weight and overweight groups. Atherogenic index and insulin resistance were closely related and a positive correlation between cholesterol and triglyceride, and ascending aortic stiffness was found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0160_abs_004_w2aab3b7c40b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results may suggest that cholesterol and triglyceride-related arterial involvement is more involved in the pathogenesis of arterial stiffness. It can be considered that \u2018being overweight\u2019 or \u2018having metabolic profile characterized by insulin resistance and dyslipidemia\u2019 are the major coexisting factors influencing the vascular structure, rather than increased androgens and premature adrenarche itself.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0160","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:06:51Z","timestamp":1624572411000},"page":"1009-1015","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of metabolic parameters and aortic elasticity in normotensive children with premature adrenarche"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-3751","authenticated-orcid":false,"given":"Eylem","family":"Topakta\u015f","sequence":"first","affiliation":[{"name":"Department of Pediatrics , University of Health Sciences, \u00dcmraniye Training and Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-5732","authenticated-orcid":false,"given":"Elif","family":"Erolu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology , University of Health Sciences, \u00dcmraniye Training and Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-8175","authenticated-orcid":false,"given":"Fatma","family":"Dursun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Sciences, \u00dcmraniye Training and Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-3452","authenticated-orcid":false,"given":"Heves","family":"K\u0131rm\u0131z\u0131bekmez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Sciences, \u00dcmraniye Training and Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"2023040101170329188_j_jpem-2021-0160_ref_001_w2aab3b7c40b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ib\u00e1\u00f1ez, L, D\u00edaz, R, L\u00f3pez-Bermejo, A, Marcos, MV. 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