{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:24:22Z","timestamp":1776335062978,"version":"3.51.2"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n Childhood osteoporosis is an uncommon condition that usually develops secondary to underlying disease states. Idiopathic juvenile osteoporosis or early onset osteoporosis is a rare cause of primary osteoporosis in childhood associated with mutations in \u201cbone fragility\u201d genes.<\/jats:p>\n <\/jats:sec>\n \n Case presentation<\/jats:title>\n The index case presented with upper back pain and was detected to have multiple vertebral fractures. Further workup for the cause revealed a homozygous benign mutation in low-density lipoprotein receptor-related protein 5, which was also detected in the mother who remained asymptomatic till presentation. The child was successfully treated with intravenous zoledronate.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The case report describes the management approach and four-year follow-up of the child.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jpem-2021-0233","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T11:40:44Z","timestamp":1627731644000},"page":"1487-1490","source":"Crossref","is-referenced-by-count":3,"title":["Idiopathic juvenile osteoporosis in a child: a four-year follow-up with review of literature"],"prefix":"10.1515","volume":"34","author":[{"given":"Aashima","family":"Dabas","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Maulana Azad Medical College and Lok Nayak Hospital , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakhi","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hindu Rao Hospital , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Khadgawat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2023040101375938963_j_jpem-2021-0233_ref_001","doi-asserted-by":"crossref","unstructured":"Galindo-Zavala, R, Bou-Torrent, R, Magallares-L\u00f3pez, B, Mir-Perell\u00f3, C, Palmaou-Fontana, N, Sevilla-Perez, P, et al.. Expert panel consensus recommendations for diagnosis and treatment of secondary osteoporosis in children. Pediatr Rheumatol 2020;18:20. https:\/\/doi.org\/10.1186\/s12969-020-0411-9.","DOI":"10.1186\/s12969-020-0411-9"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_002","doi-asserted-by":"crossref","unstructured":"Nasomyont, N, Hornung, LN, Gordon, CM, Wasserman, H. Outcomes following intravenous bisphosphonate infusion in pediatric patients: a 7-year retrospective chart review. Bone 2019;121:60\u20137. https:\/\/doi.org\/10.1016\/j.bone.2019.01.003.","DOI":"10.1016\/j.bone.2019.01.003"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_003","doi-asserted-by":"crossref","unstructured":"Genant, HK, Jergas, M, Palermo, L, Nevitt, M, Valentin, RS, Black, D, et al.. Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis the Study of Osteoporotic Fractures Research Group. J Bone Miner Res 1996;11:984\u201396. https:\/\/doi.org\/10.1002\/jbmr.5650110716.","DOI":"10.1002\/jbmr.5650110716"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_004","doi-asserted-by":"crossref","unstructured":"Baroncelli, GI, Vierucci, F, Bertelloni, S, Erba, P, Zampollo, E, Giuca, MR. Pamidronate treatment stimulates the onset of recovery phase reducing fracture rate and skeletal deformities in patients with idiopathic juvenile osteoporosis: comparison with untreated patients. J Bone Miner Metabol 2013;31:533\u201343. https:\/\/doi.org\/10.1007\/s00774-013-0438-9.","DOI":"10.1007\/s00774-013-0438-9"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_005","doi-asserted-by":"crossref","unstructured":"Caetano da Silva, C, Ricquebourg, M, Orcel, P, Fabre, S, Funck-Brentano, T, Cohen-Solal, M,et al.. More severe phenotype of early-onset osteoporosis associated with recessive form of LRP5 and combination with DKK1 or WNT3A. Mol Genet Genom Med 2021;9:e1681. https:\/\/doi.org\/10.1002\/mgg3.1681.","DOI":"10.1002\/mgg3.1681"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_006","unstructured":"Gene, LRP5. LDL receptor related protein 5 (plus strand). Reference SNP (rs) report; 2021. Available from: https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs545382 [Accessed 25 Mar 2021]."},{"key":"2023040101375938963_j_jpem-2021-0233_ref_007","doi-asserted-by":"crossref","unstructured":"St\u00fcrznickel, J, Rolvien, T, Delsmann, A, Butscheidt, S, Barvencik, F, Mundlos, S, et al.. Clinical phenotype and relevance of LRP5 and LRP6 variants in patients with early-onset osteoporosis (EOOP). J\u00a0Bone Miner Res 2021;36:271\u201382. https:\/\/doi.org\/10.1002\/jbmr.4197.","DOI":"10.1002\/jbmr.4197"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_008","doi-asserted-by":"crossref","unstructured":"Saraff, V, Sahota, J, Crabtree, N, Sakka, S, Shaw, NJ, H\u00f6gler, W. Efficacy and treatment costs of zoledronate versus pamidronate in paediatric osteoporosis. Arch Dis Child 2018;103:92\u20134. https:\/\/doi.org\/10.1136\/archdischild-2017-313234.","DOI":"10.1136\/archdischild-2017-313234"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_009","doi-asserted-by":"crossref","unstructured":"Melchior, R, Zabel, B, Spranger, J, Schumaker, R. Effective parenteral clodronate treatment of a child with severe juvenile idiopathic osteoporosis. Eur J Pediatr 2005;164:22\u20137. https:\/\/doi.org\/10.1007\/s00431-004-1541-7.","DOI":"10.1007\/s00431-004-1541-7"},{"key":"2023040101375938963_j_jpem-2021-0233_ref_010","doi-asserted-by":"crossref","unstructured":"Papakonstantinou, O, Sakalidou, M, Atsali, E, Bizimi, V, Mendrinou, M, Alexopoulou, E, et al.. Radiographic and MR imaging findings of the spine after bisphosphonate treatment, in a child with idiopathic juvenile osteoporosis. Case Rep Radiol 2015;2015:1\u20134.https:\/\/doi.org\/10.1155\/2015\/727510.","DOI":"10.1155\/2015\/727510"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0233\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0233\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T21:07:42Z","timestamp":1680383262000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0233\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":10,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,8,6]]},"published-print":{"date-parts":[[2021,11,25]]}},"alternative-id":["10.1515\/jpem-2021-0233"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2021-0233","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]}}}