{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:16:35Z","timestamp":1780920995466,"version":"3.54.1"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0267_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Lack of systematic evaluation of short stature results in unnecessary work-up on one hand while missing pathology on the other. We have developed a mobile application that guides work-up based on age, auxology (height, BMI, and corrected standard deviation score), and skeletal maturation with an aim of reducing the diagnostic errors. Aim of this study is to develop and validate a mobile application for point of care evaluation of short stature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0267_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The application was developed (n=400) and validated (n=412) on children and adolescents (2\u201318 years of age) presenting to our Pediatric Endocrinology Clinic with short stature. Height standard deviation score thresholds determining the need for workup were derived from Receiver Operating Characteristics (ROC) curve. Student\u2019s t-test and ROC curves were used to identify the most appropriate parameter differentiating constitutional delay of growth and puberty (CDGP) from pathological and nutritional from endocrine causes. The validation of the application involved comparing the application predicted and clinical diagnosis at each step of the algorithm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0267_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mobile application diagnosis was concordant with clinical diagnosis in 408 (99.0%) with discordance in four (two with CDGP labeled as growth hormone deficiency [GHD] and two with GHD labeled as CDGP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0267_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Mobile application guided short stature assessment has a high concordance with the clinical diagnosis and is expected to help point of care short stature evaluation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0267","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T20:24:17Z","timestamp":1631823857000},"page":"147-153","source":"Crossref","is-referenced-by-count":3,"title":["Development and validation of a mobile application for point of care evaluation of growth failure"],"prefix":"10.1515","volume":"35","author":[{"given":"Riddhi V.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology , Regency Center for Diabetes Endocrinology & Research , Kanpur , India"},{"name":"GROW Society, Growth & Obesity Workforce , Kanpur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag T.","family":"Bajpai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Regency Center for Diabetes Endocrinology & Research , Kanpur , India"},{"name":"GROW Society, Growth & Obesity Workforce , Kanpur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemangkumar V.","family":"Mendpara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Regency Center for Diabetes Endocrinology & Research , Kanpur , India"},{"name":"GROW Society, Growth & Obesity Workforce , Kanpur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetankumar C.","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Regency Center for Diabetes Endocrinology & Research , Kanpur , India"},{"name":"GROW Society, Growth & Obesity Workforce , Kanpur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajili S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Regency Center for Diabetes Endocrinology & Research , Kanpur , India"},{"name":"GROW Society, Growth & Obesity Workforce , Kanpur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalabh","family":"Dixit","sequence":"additional","affiliation":[{"name":"Infolancers Private Limited , Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi K.","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Regency Center for Diabetes Endocrinology & Research , Kanpur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"2022020803263084957_j_jpem-2021-0267_ref_001","unstructured":"Bajpai, A, Agarwal, N. Growth failure. In: MedEClasses Pediatric endocrinology, Bajpai, A, Patel, R, Dave, C, Agarwal, N, editors. Kanpur: Grow society Press, 2019:49\u201353 pp."},{"key":"2022020803263084957_j_jpem-2021-0267_ref_002","doi-asserted-by":"crossref","unstructured":"Sisley, S, Trujillo, MV, Khoury, J, Backeljauw, P. Low incidence of pathology detection and high cost of screening in the evaluation of asymptomatic short children. J Pediatr 2013;163:1045\u201351. https:\/\/doi.org\/10.1016\/j.jpeds.2013.04.002.","DOI":"10.1016\/j.jpeds.2013.04.002"},{"key":"2022020803263084957_j_jpem-2021-0267_ref_003","doi-asserted-by":"crossref","unstructured":"Wit, JM, Kamp, GA, Oostdijk, W. Towards a rational and efficient diagnostic approach in children referred for growth failure to the general paediatrician. 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