{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:47:13Z","timestamp":1782229633172,"version":"3.54.5"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0296_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We report a case of an infant with nephrogenic diabetes insipidus (NDI) diagnosed by the measurement of serum copeptin. There is only one study that previously evaluated the use of copeptin measurement in a pediatric patient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0296_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We present a 10-month-old child with polyuria\u2013polydipsia syndrome (PPS) and hypernatremia that could not support water restriction due to increased risk of dehydration and worsening of his condition. Therefore, plasma measurement of copeptin allowed the diagnosis of NDI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0296_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The water deprivation test (WDT) is considered the gold standard for diagnosis in PPS. However, WDT has serious limitations regarding its interpretation. Furthermore, the WDT can cause dehydration and hypernatremia, especially in young children. Therefore, the measurement of plasma copeptin seems to be a promising method to perform an earlier, safer, and accurate investigation of PPS. Up to now, our study is the second to report the usefulness of copeptin in children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0296","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T02:29:13Z","timestamp":1626920953000},"page":"1475-1479","source":"Crossref","is-referenced-by-count":8,"title":["The usefulness of copeptin for the diagnosis of nephrogenic diabetes insipidus in infancy: a case report"],"prefix":"10.1515","volume":"34","author":[{"given":"Let\u00edcia","family":"Bitencourt","sequence":"first","affiliation":[{"name":"Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine , Federal University of Minas Gerais (UFMG) , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Luisa","family":"Fischer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine , Federal University of Minas Gerais (UFMG) , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Lacerda","family":"de Oliveira Campos","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine , Federal University of Minas Gerais (UFMG) , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Alves Soares","family":"Vaz de Castro","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine , Federal University of Minas Gerais (UFMG) , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Bruna Camilo","family":"Soares de Brito","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine , Federal University of Minas Gerais (UFMG) , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Mazieiro","family":"Versiani","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine , UFMG , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Santana","family":"Soares","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine , UFMG , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Beaudette","family":"Drummond","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine , UFMG , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-3882","authenticated-orcid":false,"given":"Ana Cristina","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine , Federal University of Minas Gerais (UFMG) , Belo Horizonte , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"2023040101375941371_j_jpem-2021-0296_ref_001","doi-asserted-by":"crossref","unstructured":"Bockenhauer, D, Bichet, DG. Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus. Nat Rev Nephrol 2015;11:576\u201388. https:\/\/doi.org\/10.1038\/nrneph.2015.89.","DOI":"10.1038\/nrneph.2015.89"},{"key":"2023040101375941371_j_jpem-2021-0296_ref_002","doi-asserted-by":"crossref","unstructured":"D\u2019Alessandri-Silva, C, Carpenter, M, Ayoob, R, Barcia, J, Chishti, A, Constantinescu, A, et al.. Diagnosis, treatment, and outcomes in children with congenital nephrogenic diabetes insipidus: a pediatric nephrology research consortium study. Front Pediatr 2019;7:550. https:\/\/doi.org\/10.3389\/fped.2019.00550.","DOI":"10.3389\/fped.2019.00550"},{"key":"2023040101375941371_j_jpem-2021-0296_ref_003","doi-asserted-by":"crossref","unstructured":"Kavanagh, C, Uy, NS. Nephrogenic diabetes insipidus. 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