{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T19:43:46Z","timestamp":1747338226775,"version":"3.40.5"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0305_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Central diabetes insipidus (DI) is a known complication following surgical resection of a suprasellar mass. There are limited data analyzing the outcomes of a standardized protocol for the management of postoperative DI in the pediatric population. We sought to fill this gap and hypothesized that utilizing a standardized protocol for fluid management (3-bag system) would reduce serum sodium fluctuations in the postoperative period after suprasellar surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0305_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective chart review was performed. Patients were identified with the following criteria: age\u00a0\u2264\u00a018 years, undergoing a surgical procedure for suprasellar mass that also had postoperative DI. The primary outcome was the variability in serum sodium during the first 48\u00a0h and between 48 and 120\u00a0h postoperatively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0305_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 21 encounters pre-protocol and 22 encounters post-protocol for neurosurgical procedures. Use of the standardized protocol was associated with a lower range of sodium within 48\u00a0h postoperatively (p=0.065) and 83% lower odds of hypernatremia (Na&gt;150\u00a0mmol\/L) within 48\u00a0h postoperatively (CI 0.039\u20130.714) after controlling for age, gender, and prior DI diagnosis. History of DI conferred a lower risk of hypernatremia as well as less sodium fluctuation within 48\u00a0h postoperatively. Younger patients, those &lt;9.7 years of age were associated with increased risk of hyponatremia and greater sodium fluctuations during the postoperative period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0305_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with postoperative DI after suprasellar surgery, using a standardized protocol for fluid management (3-bag system) appears to reduce serum sodium variability in the first 48\u00a0h after surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0305","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T22:02:55Z","timestamp":1632607375000},"page":"197-203","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating a standardized protocol for the management of diabetes insipidus in pediatric neurosurgical patients"],"prefix":"10.1515","volume":"35","author":[{"given":"Daniel","family":"Mak","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, University of Arkansas for Medical Sciences\/Arkansas Children's Hospital , Professional Building 3, 1900 Maryland Ave , Little Rock , AR , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra L.","family":"Schaller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Critical Care Medicine, University of Tennessee Health Sciences Center , Memphis , TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie A.","family":"Storgion","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Critical Care Medicine, University of Tennessee Health Sciences Center , Memphis , TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-8701","authenticated-orcid":false,"given":"Amit","family":"Lahoti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, University of Tennessee Health Sciences Center , Memphis , TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"2022020803263080702_j_jpem-2021-0305_ref_001","doi-asserted-by":"crossref","unstructured":"Lyen, KR, Grant, DB. 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