{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:43:03Z","timestamp":1762508583192,"version":"3.40.5"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"11","funder":[{"name":"Turkey Pediatric Endocrinology and Diabetes Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0343_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>There is a complex interaction between the anti-m\u00fcllerian hormone (AMH) and hypothalamic\u2013pituitary\u2013gonadal axis. However, the effect of gonadotropin-releasing hormone (GnRH) stimulation on AMH levels is not clearly known. In the study, we aimed to evaluate the effect of GnRH stimulation on AMH levels in central precocious puberty (CPP) and isolated premature thelarche (PT) groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0343_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sixty-three girls with breast development before the age of 8 were enrolled in the study. GnRH test was performed on all subjects. Blood samples for follicle-stimulating hormone (FSH), luteinizing hormone (LH), and AMH levels were taken at basal, 40th, and 90th minute of GnRH test. Subjects were grouped as CPP and PT group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0343_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After GnRH stimulation, AMH levels increased significantly at the 40th minute and the stimulating effect of GnRH on AMH continued till the 90th minute (p: 0.0001). There was a positive correlation between basal and 90th-minute AMH levels (r: 479, p: 0.0001). The highest FSH, LH, and AMH times were significantly different after the GnRH stimulation (p: 0.001, p: 0.001, and p: 0.007). Although the CPP group had a lower basal AMH level than the PT group\u2019s basal AMH level; AMH response to GnRH stimulation was not different (p&gt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0343_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our study, which examined the effect of GnRH stimulation on AMH levels in early pubertal development disorders for the first time, GnRH stimulated AMH secretion rapidly, correlated with basal AMH. Basal AMH levels were lower in patients with CPP than in those with PT; however, the effect of GnRH stimulation on AMH levels was similar in both groups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0343","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T22:06:39Z","timestamp":1628028399000},"page":"1385-1391","source":"Crossref","is-referenced-by-count":2,"title":["The effect of GnRH stimulation on AMH regulation in central precocious puberty and isolated premature thelarche"],"prefix":"10.1515","volume":"34","author":[{"given":"Nursel Muratoglu","family":"Sahin","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology , Health Sciences University, Dr Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease, Health Implementation and Research Center , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Nursun","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology , Hacettepe University , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aslihan Arasli","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Health Sciences University, Dr Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease, Health Implementation and Research Center , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senay Savas","family":"Erdeve","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Health Sciences University, Dr Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease, Health Implementation and Research Center , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3974-2872","authenticated-orcid":false,"given":"Semra","family":"Cetinkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Health Sciences University, Dr Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease, Health Implementation and Research Center , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Health Sciences University, Dr Sami Ulus Obstetrics and Gynecology, Children\u2019s Health and Disease, Health Implementation and Research Center , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"2023040101375945815_j_jpem-2021-0343_ref_001","doi-asserted-by":"crossref","unstructured":"Chemaitilly, W, Trivin, C, Adan, L, Gall, V, Sainte-Rose, C, Brauner, R. 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