{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:38:51Z","timestamp":1789274331209,"version":"build-2803163510"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0366_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Physical examinations to characterize pubertal maturation may be unacceptable for children enrolled in research studies. Studies confirm the utility of pubertal self staging for research, but there has been limited comparison of self examination with hormone biomarkers. Our objective was to assess concordance of\u00a0pubertal self staging with hormone biomarkers of puberty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0366_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participants were enrolled in the Health Outcomes and Measures of the Environment Study, a longitudinal pregnancy and birth cohort study. At age 12 years, 139 females and 112 males completed pubertal self staging including breast and pubic hair development in females and pubic hair development in males. No clinical physical examination was performed. Hormone concentrations were measured in 102 females and 96 males including serum dehydroepiandrosterone sulfate, luteinizing hormone, and follicle-stimulating hormone in all; estradiol in females; and testosterone in males.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0366_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Estradiol was significantly associated with female breast stage, even when adjusted for BMI, with geometric least squares means (95%CI) of 13.2 (8.7, 20.2), 38.3 (29.9, 49.1), 59.4 (39.8, 88.6), and 81.2 (45.6, 144) pg\/mL for breast stage 1\u20132, 3, 4, and 5, respectively. Testosterone was significantly associated with male pubic hair stage, with adjusted geometric least squares means (95%CI) of 37.6 (19.9, 71.1), 43.4 (27.7, 68.3), 126 (78.4, 203), 275 (146, 521), and 559 (237, 1319) ng\/dL for pubic hair stage 1, 2, 3, 4, and 5, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0366_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Self assessed pubertal development was positively associated with hormonal biomarkers of puberty.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0366","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T20:43:07Z","timestamp":1629924187000},"page":"1531-1541","source":"Crossref","is-referenced-by-count":22,"title":["Comparing adolescent self staging of pubertal development with hormone biomarkers"],"prefix":"10.1515","volume":"34","author":[{"given":"Nana-Hawa","family":"Yayah Jones","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Biostatistics and Epidemiology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of General and Community Pediatrics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of General and Community Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi J.","family":"Kalkwarf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Gastroenterology, Hepatology & Nutrition, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health, Brown University , Providence , RI , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Lanphear","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Simon Fraser University , Burnaby , BC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M.","family":"Cecil","sequence":"additional","affiliation":[{"name":"Department of Radiology , Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Yolton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of General and Community Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati , OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"2021120918514218991_j_jpem-2021-0366_ref_001","doi-asserted-by":"crossref","unstructured":"Kasper-Sonnenberg, M, Wittsiepe, J, Wald, K, Koch, HM, Wilhelm, M. 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