{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:09:17Z","timestamp":1745417357723,"version":"3.37.3"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"11","funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["QNRF-NPRP 10-6100017-AXX"],"award-info":[{"award-number":["QNRF-NPRP 10-6100017-AXX"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0452_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Children with antibody positive type 1 diabetes mellitus (type 1 diabetes) are at an increased risk of developing celiac disease (CD) which suggests a common autoimmune basis with both high-risk human lymphocyte antigen (HLA) and non-HLA factors playing a role in the pathophysiology. We aim to describe the prevalence, immune profile, and clinical characteristics of children with CD who have type 1 diabetes mellitus in Qatar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0452_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All children (aged 0\u201318 years) attending a regional diabetes clinic with antibody positive type 1 diabetes were screened for CD. Measurement of tissue transglutaminase IgA and IgG as well as anti-endomysial antibody, was done, clinical details about the birth history, family history of diabetes and CD, age of onset, and ethnicity were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0452_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of the 1,325 children with antibody positive type 1 diabetes, 54 were identified to have CD on screening and then confirmed on small bowel biopsy. The prevalence of CD in the type 1 diabetes childhood population in Qatar is 4.07%. CD and type 1 diabetes were more prevalent in the Qatari children (n=32) as compared to non-Qatari (n=22) and occurred mostly in the age group 6\u201310 years. The most common type 1 diabetes antibodies in children with CD were glutamic acid decarboxylase and insulin autoantibody. Twelve subjects were asymptomatic for CD symptoms and picked up only on screening.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0452_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prevalence of CD in children with type 1 diabetes in Qatar is comparable to reports from around the world. Many children were asymptomatic and thus routine screening is recommended.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0452","type":"journal-article","created":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T03:45:15Z","timestamp":1630208715000},"page":"1457-1461","source":"Crossref","is-referenced-by-count":3,"title":["The prevalence, immune profile, and clinical characteristics of children with celiac disease and type 1 diabetes mellitus in the state of Qatar"],"prefix":"10.1515","volume":"34","author":[{"given":"Basma","family":"Haris","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abdellatief","sequence":"additional","affiliation":[{"name":"Department of Information Management and Technology , Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Afyouni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasneem","family":"Abdel-Karim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayma","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Al-Maadheed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Zyoud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Elawwa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawziya","family":"Al-Khalaf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-7112","authenticated-orcid":false,"given":"Khalid","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Endocrinology, Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"2023040101375947459_j_jpem-2021-0452_ref_001","doi-asserted-by":"crossref","unstructured":"Garrote, JA, G\u00f3mez-Gonz\u00e1lez, E, Bernardo, D, Arranz, E, Chirdo, F. 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