{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T04:50:21Z","timestamp":1685767821270},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"name":"JSPS KAKENHI","award":["19K17375"],"award-info":[{"award-number":["19K17375"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0555_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In recent years, research on behavioral and psychiatric problems of adults with Prader-Willi syndrome (PWS) has gained attention. However, no report is available regarding the relationship between psychiatric illness and type 2 diabetes mellitus (T2DM) in patients with PWS. Therefore, we evaluated a behavioral assessment to address the lack of data on the association between psychiatric behavior and T2DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0555_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective single-center study of patients with PWS. Patients with PWS whose blood tests were performed in our hospital between January 2018 and December 2019 and aged &gt;10\u00a0years were included. We evaluated the data, including the behavioral patterns of Japanese PWS patients with T2DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0555_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 114 patients were evaluated; 33 patients (28.9%) developed T2DM. The age of T2DM onset was 18.0\u00a0years (interquartile range [IQR], 14.6\u201321.4\u00a0years). The median body mass index at T2DM onset was 33.7\u00a0kg\/m<jats:sup>2<\/jats:sup> (IQR, 30.0\u201337.4\u00a0kg\/m<jats:sup>2<\/jats:sup>). Between-group comparisons of the intelligence quotient, Food-Related Problem Questionnaire (FRPQ), and Japanese versions of the Short Sensory Profile and Aberrant Behavior Checklist showed a significant difference only in FRPQ scores (p=0.003).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0555_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The occurrence of T2DM among Japanese patients with PWS remains high. Only the FRPQ was significantly different between the T2DM and the non-T2DM group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0555","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T12:28:31Z","timestamp":1637238511000},"page":"89-96","source":"Crossref","is-referenced-by-count":1,"title":["Psychiatric behavioral effect and characteristics of type 2 diabetes mellitus on Japanese patients with Prader-Willi syndrome: a preliminary retrospective study"],"prefix":"10.1515","volume":"35","author":[{"given":"Yuji","family":"Oto","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Dokkyo Medical University Saitama Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Dokkyo Medical University Saitama Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Dokkyo Medical University Saitama Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology , National Research Institute for Child Health and Development , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohei","family":"Saima","sequence":"additional","affiliation":[{"name":"Department of Psychiatry , Dokkyo Medical University Saitama Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry , Dokkyo Medical University Saitama Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry , Dokkyo Medical University Saitama Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Nagai","sequence":"additional","affiliation":[{"name":"Nakagawanosato Ryoiku Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyo","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Dokkyo Medical University Saitama Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"2023040100325810848_j_jpem-2021-0555_ref_001","doi-asserted-by":"crossref","unstructured":"Butler, MG, Miller, JL, Forster, JL. 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