{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:12:49Z","timestamp":1793121169481,"version":"4.5.0"},"reference-count":5,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0565_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Recent studies have demonstrated an increase in the frequency of idiopathic central precocious puberty (CPP) during the severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic. We compared the demographic, anthropometric, and clinical characteristics of idiopathic CPP patients diagnosed during a one-year period of the COVID-19 pandemic with the characteristics of patients diagnosed during the same period in the previous three-years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0565_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Demographic, clinical, anthropometric, and laboratory data of all patients diagnosed in our Pediatric Endocrinology clinic with idiopathic CPP during a one-year period of the COVID-19 pandemic (April 2020\u2013March 2021) and a three-year period before the pandemic (April 2017\u2013March 2020) were evaluated retrospectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0565_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 124 patients (124 girls, zero boys) diagnosed with idiopathic CPP were included in this study. Sixty-six patients in the three-year period before the COVID-19 pandemic (April 2017\u2013March 2020) and 58 patients (46.8%) in the one-year period during the COVID-19 pandemic period (April 2020\u2013March 2021) were diagnosed with idiopathic CPP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0565_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study\u2019s findings suggest that the number of girls diagnosed with idiopathic CPP during the one-year study period during the pandemic was more than double that of any of the previous three-years.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0565","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T07:10:06Z","timestamp":1639033806000},"page":"249-251","source":"Crossref","is-referenced-by-count":37,"title":["Increased frequency of idiopathic central precocious puberty in girls during the COVID-19 pandemic: preliminary results of a tertiary center study"],"prefix":"10.1515","volume":"35","author":[{"given":"Sezer","family":"Acar","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology , Dr. Beh\u00e7et Uz Children\u2019s Education and Research Hospital , Izmir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzat","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Dr. Beh\u00e7et Uz Children\u2019s Education and Research Hospital , Izmir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"2022020803263084233_j_jpem-2021-0565_ref_001","doi-asserted-by":"crossref","unstructured":"Verzani, M, Bizzarri, C, Chioma, L, Bottaro, G, Pedicelli, S, Cappa, M. Impact of COVID-19 pandemic lockdown on early onset of puberty: experience of an Italian tertiary center. Ital J Pediatr 2021;47:52. https:\/\/doi.org\/10.1186\/s13052-021-01015-6.","DOI":"10.1186\/s13052-021-01015-6"},{"key":"2022020803263084233_j_jpem-2021-0565_ref_002","doi-asserted-by":"crossref","unstructured":"Stagi, S, De Masi, S, Bencini, E, Losi, S, Paci, S, Parpagnoli, M, et al.. Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic. Ital J Pediatr 2020;46:165. https:\/\/doi.org\/10.1186\/s13052-020-00931-3.","DOI":"10.1186\/s13052-020-00931-3"},{"key":"2022020803263084233_j_jpem-2021-0565_ref_003","doi-asserted-by":"crossref","unstructured":"Carel, JC, Eugster, EA, Rogol, A, Ghizzoni, L, Palmert, MR, ESPE-LWPES GnRH Analogs Consensus Conference Group, et al.. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 2009;123:e752\u201362. https:\/\/doi.org\/10.1542\/peds.2008-1783.","DOI":"10.1542\/peds.2008-1783"},{"key":"2022020803263084233_j_jpem-2021-0565_ref_004","doi-asserted-by":"crossref","unstructured":"Brix, N, Ernst, A, Lauridsen, LLB, Parner, ET, Arah, OA, Olsen, J, et al.. Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses. Int J Epidemiol 2020;49:834\u201344. https:\/\/doi.org\/10.1093\/ije\/dyaa056.","DOI":"10.1093\/ije\/dyaa056"},{"key":"2022020803263084233_j_jpem-2021-0565_ref_005","doi-asserted-by":"crossref","unstructured":"Boafo, A, Greenham, S, Alenezi, S, Robillard, R, Pajer, K, Tavakoli, P, et al.. Could long-term administration of melatonin to prepubertal children affect timing of puberty? A clinician\u2019s perspective. Nat Sci Sleep 2019;11:1\u201310. https:\/\/doi.org\/10.2147\/nss.s181365.","DOI":"10.2147\/NSS.S181365"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0565\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0565\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T03:28:23Z","timestamp":1644290903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0565\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,10,1]]},"published-print":{"date-parts":[[2022,2,23]]}},"alternative-id":["10.1515\/jpem-2021-0565"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2021-0565","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,8]]}}}