{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:51Z","timestamp":1747198251510,"version":"3.40.5"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"NIH\/NCRR SC-CTSI","award":["UL1 TR000130"],"award-info":[{"award-number":["UL1 TR000130"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0600_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural endocrine tumor (ROHHAD-NET) syndrome is\u00a0a\u00a0youth-onset constellation of symptoms including rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation. Despite growing understanding of the clinical classification of this syndrome there is limited investigation into treatment of the rapid-onset obesity which can be progressive and life-limiting. The purpose of this case report is to describe the clinical timeline and treatment of severe obesity in a patient with of\u00a0ROHHAD-NET and propose recommendations for the treatment of associated obesity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0600_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We present the case of a 10-year-old female with a clinical presentation consistent with ROHHAD-NET who achieved clinically meaningful weight loss with a combination of lifestyle modification and anti-obesity pharmacotherapies. We report on the use of three separate pharmacological agents and ultimately the referral for bariatric surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0600_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Given that early-onset obesity and hypoventilation are life-limiting components of this condition, early recognition and treatment are essential to improve health outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0600","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T20:52:52Z","timestamp":1640551972000},"page":"543-548","source":"Crossref","is-referenced-by-count":4,"title":["Weight management in youth with rapid-onset obesity with hypothalamic dysregulation, hypoventilation, autonomic dysregulation, and neural crest tumor (ROHHAD-NET): literature search and case report"],"prefix":"10.1515","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-8312","authenticated-orcid":false,"given":"Ian","family":"Marpuri","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Center for Diabetes, Endocrinology and Metabolism , Children\u2019s Hospital Los Angeles , Los Angeles , CA , USA"},{"name":"Keck School of Medicine of USC , Los Angeles , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Ra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Children\u2019s Hospital of Los Angeles , Los Angeles , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-8332","authenticated-orcid":false,"given":"Monica N.","family":"Naguib","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Diabetes, Endocrinology and Metabolism , Children\u2019s Hospital Los Angeles , Los Angeles , CA , USA"},{"name":"Keck School of Medicine of USC , Los Angeles , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaina P.","family":"Vidmar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Diabetes, Endocrinology and Metabolism , Children\u2019s Hospital Los Angeles , Los Angeles , CA , USA"},{"name":"Keck School of Medicine of USC , Los Angeles , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"2023033123535382228_j_jpem-2021-0600_ref_001","doi-asserted-by":"crossref","unstructured":"Harvengt, J, Gernay, C, Mastouri, M, Farhat, N, Lebrethon, MC, Seghaye, MC, et al.. ROHHAD(NET) syndrome: systematic review of the clinical timeline and recommendations for diagnosis and prognosis. J Clin Endocrinol Metab 2020;105:12\u20139. https:\/\/doi.org\/10.1210\/clinem\/dgaa247.","DOI":"10.1210\/clinem\/dgaa247"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_002","doi-asserted-by":"crossref","unstructured":"August, GP, Caprio, S, Fennoy, I, Freemark, M, Kaufman, FR, Lustig, RH, et al.. Prevention and treatment of pediatric obesity: an Endocrine Society clinical practice guideline based on expert opinion. J Clin Endocrinol Metabol 2008;93:23\u201337. https:\/\/doi.org\/10.1210\/jc.2007-2458.","DOI":"10.1210\/jc.2007-2458"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_003","doi-asserted-by":"crossref","unstructured":"Barlow, SE, Expert Committee. Expert committee recommendations regarding the prevention, assessment, and\u00a0treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007;120(4 Suppl):S164\u201392. https:\/\/doi.org\/10.1542\/peds.2007-2329C.","DOI":"10.1542\/peds.2007-2329C"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_004","doi-asserted-by":"crossref","unstructured":"Cardel, MI, Atkinson, MA, Taveras, EM, Holm, JC, Kelly, AS. Obesity treatment among adolescents: a review of current evidence and future directions. JAMA Pediatr 2020;174:609\u201317. https:\/\/doi.org\/10.1001\/jamapediatrics.2020.0085.","DOI":"10.1001\/jamapediatrics.2020.0085"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_005","doi-asserted-by":"crossref","unstructured":"Pratt, JSA, Browne, A, Browne, NT, Bruzoni, M, Cohen, M, Desai, A, et al.. ASMBS pediatric metabolic and bariatric surgery guidelines, 2018. 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Int J Gen Med 2021;14:319\u201326. https:\/\/doi.org\/10.2147\/ijgm.s293377.","DOI":"10.2147\/IJGM.S293377"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_008","doi-asserted-by":"crossref","unstructured":"Fox, CK, Kelly, AS. Pharmacotherapy for severe obesity in children. Clin Pediatr 2015;54:1302. https:\/\/doi.org\/10.1177\/0009922815580407.","DOI":"10.1177\/0009922815580407"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_009","doi-asserted-by":"crossref","unstructured":"Fox, CK, Marlatt, KL, Rudser, KD, Kelly, AS. Topiramate for weight reduction in adolescents with severe obesity. Clin Pediatr 2015;54:19\u201324. https:\/\/doi.org\/10.1177\/0009922814542481.","DOI":"10.1177\/0009922814542481"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_010","doi-asserted-by":"crossref","unstructured":"Ryder, JR, Kaizer, A, Rudser, KD, Gross, A, Kelly, AS, Fox, CK. Effect of phentermine on weight reduction in a pediatric weight management clinic. Int J Obes 2017;41:90\u20133. https:\/\/doi.org\/10.1038\/ijo.2016.185.","DOI":"10.1038\/ijo.2016.185"},{"key":"2023033123535382228_j_jpem-2021-0600_ref_011","doi-asserted-by":"crossref","unstructured":"Kelly, AS, Rudser, KD, Nathan, BM, Fox, CK, Metzig, AM, Coombes, BJ, et al.. The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial. JAMA Pediatr 2013;167:355\u201360. https:\/\/doi.org\/10.1001\/jamapediatrics.2013.1045.","DOI":"10.1001\/jamapediatrics.2013.1045"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0600\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0600\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T13:12:40Z","timestamp":1680354760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0600\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2,16]]},"published-print":{"date-parts":[[2022,4,26]]}},"alternative-id":["10.1515\/jpem-2021-0600"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2021-0600","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"type":"print","value":"0334-018X"},{"type":"electronic","value":"2191-0251"}],"subject":[],"published":{"date-parts":[[2021,12,23]]}}}