{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:59:36Z","timestamp":1784566776337,"version":"3.55.0"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0644_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Children with type 1 diabetes (T1D) having diabetic nephropathy (DN) are at increased risk of developing end stage renal disease. The present study aimed to determine the prevalence of DN and its predictors in Indian children and youth with T1D.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0644_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study included 319 children and youth (2.6\u201321 years) with T1D having disease duration of at least 2 years. Demographic data and laboratory findings were obtained using standard questionnaires and protocols. Diagnosis of diabetic nephropathy was based on albuminuria on two occasions within a period of 3\u00a0months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0644_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of DN in our study subjects was\u00a013.4%. 7.5% subjects were known cases of diabetic nephropathy on treatment with enalapril. Hypertension was found in 14.3% subjects with DN in contrast to 4.1% without DN (p&lt;0.05). Duration of diabetes and estimated glucose disposal rate were the important predictors of DN. Interestingly, of the 43 children with DN, 11.3% (n=8) were under 10 years age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0644_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found a high prevalence of DN in children and youth with T1D including in children under the age of 10 years. Early screening and timely intervention are required to retard the disease progression and avoid end stage renal disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0644","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T01:12:15Z","timestamp":1647738735000},"page":"585-592","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of nephropathy in Indian children and youth with type 1 diabetes mellitus"],"prefix":"10.1515","volume":"35","author":[{"given":"Madhura","family":"Karguppikar","sequence":"first","affiliation":[{"name":"Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirantap","family":"Oza","sequence":"additional","affiliation":[{"name":"Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Shah","sequence":"additional","affiliation":[{"name":"Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaman","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"},{"name":"Interdisciplinary School of Health Sciences, Savitribai Phule University , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Gondhalekar","sequence":"additional","affiliation":[{"name":"Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"},{"name":"Interdisciplinary School of Health Sciences, Savitribai Phule University , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"2023033121124494863_j_jpem-2021-0644_ref_001","doi-asserted-by":"crossref","unstructured":"Whiting, DR, Guariguata, L, Weil, C, Shaw, J. 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