{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:21:49Z","timestamp":1761157309006,"version":"3.40.5"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0674_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>A highly invasive pathological diagnosis is necessary to differentiate central diabetes insipidus (CDI) with a thickened pituitary stalk. Lymphocytic infundibulo-hypophysitis (LIH) due to autoimmune involvement of the pituitary stalk is a differentiating disease, and anti-rabphilin-3A antibody (Rab3A-Ab) positivity was recently reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0674_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 7-year-old boy was diagnosed with CDI after having polyuria for two months. He showed growth hormone deficiency with reduced growth rate. Brain magnetic resonance imaging (MRI) revealed a thickened pituitary stalk. The placental alkaline phosphatase level of the cerebrospinal fluid, tumor marker for germ cell tumors, was below the level of sensitivity. No skin or bone findings suggestive of Langerhans cell histiocytosis were detected. Eight months after CDI onset, Rab3A-Ab was positive, and MRI showed shrinking of the thickened pituitary stalk, leading to the diagnosis with LIH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0674_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Rab3A-Ab is a useful adjunctive diagnostic tool for childhood-onset LIH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0674","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T11:42:08Z","timestamp":1643974928000},"page":"687-690","source":"Crossref","is-referenced-by-count":8,"title":["A 7-year-old boy with central diabetes insipidus presenting with thickened pituitary stalk and anti-rabphilin-3A antibody positivity"],"prefix":"10.1515","volume":"35","author":[{"given":"Kazutaka","family":"Morota","sequence":"first","affiliation":[{"name":"Department of Paediatrics , Nagaoka Red Cross Hospital , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , Nagaoka Red Cross Hospital , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Sawano","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, Department of Homeostatic Regulation and Development , Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , Nagaoka Red Cross Hospital , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes , Daido Hospital , Nagoya , Aichi , Japan"},{"name":"Department of Endocrinology , Diabetes and Metabolism, Fujita Health University , Toyoake , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Diabetes and Metabolism, Fujita Health University , Toyoake , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Diabetes and Metabolism, Fujita Health University , Toyoake , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Sugimura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Diabetes and Metabolism, Fujita Health University , Toyoake , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-661X","authenticated-orcid":false,"given":"Keisuke","family":"Nagasaki","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , Nagaoka Red Cross Hospital , Niigata , Japan"},{"name":"Division of Paediatrics, Department of Homeostatic Regulation and Development , Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"2023033121124489756_j_jpem-2021-0674_ref_001","doi-asserted-by":"crossref","unstructured":"Ji, X, Wang, Z, Wang, W, Gao, L, Guo, X, Feng, C, et al.. 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