{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:36:35Z","timestamp":1790836595048,"version":"4.1.0"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","issue":"8","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Shaoxing Scientific Research Fund ProjectShaoxing city health committee","award":["2017CX027"],"award-info":[{"award-number":["2017CX027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0691_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To explore the associations of environmental endocrine disruptors on precocious puberty in girls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0691_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a case-control study in which 30 girls with precocious puberty and 46 age- and race-matched prepubertal females were enrolled. The concentrations of 10 environment endocrine disruptors (bisphenol A, bisphenol B, butylparaben, propylparaben, ethvlparaben, methylparaben, mono-butyl phthalate, mono-2-ethylhexyl phthalate, monoethyl phthalate, and monomethyl phthalate) in urine and 10 steroid hormones (dihydrotestosterone, corticosterone, hydrocortisone, 11-deoxycortisol, 17\u03b1-hydroxy progesterone, 4-androstene-3,17-dione, estrone, deoxycorticosterone, pregnenolone, and dehydroepiandrosterone) in serum were detected with the liquid chromatography-mass spectrometry (LC-MS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0691_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>According to the Mann\u2013Whitney U test, urinary levels of bisphenol A, monobutyl phthalate, and monomethyl phthalate were significantly higher in the precocious group than in the prepubertal group, and blood levels of hydrocortisone, 11-deoxycortisol, corticosterone, deoxycorticosterone, and pregnenolone were significantly lower in the precocious group than in the prepubertal group (p&lt;0.05, VIP&gt;1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0691_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings confirm the association between phthalate exposure and the incidence of precocious puberty in girls. Control and reduction of children exposure to phthalate esters should be considered as a health priority.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0691","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T03:35:01Z","timestamp":1655091301000},"page":"989-997","source":"Crossref","is-referenced-by-count":22,"title":["A preliminary study on the relationship between environmental endocrine disruptors and precocious puberty in girls"],"prefix":"10.1515","volume":"35","author":[{"given":"Fang","family":"Zhou","sequence":"first","affiliation":[{"name":"Traditional Chinese Medical Hospital of Zhuji , Zhuji , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Jin","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medical Hospital of Zhuji , Zhuji , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medical Hospital of Zhuji , Zhuji , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medical Hospital of Zhuji , Zhuji , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angzhi","family":"Ye","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medical Hospital of Zhuji , Zhuji , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Hou","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medical Hospital of Zhuji , Zhuji , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"2023033122070751538_j_jpem-2021-0691_ref_001","doi-asserted-by":"crossref","unstructured":"Kim, YJ, Kwon, A, Jung, MK, Kim, KE, Suh, J, Chae, HW, et al.. Incidence and prevalence of central precocious puberty in Korea: an epidemiologic study based on a national database. J Pediatr 2019;208:221\u20138. https:\/\/doi.org\/10.1016\/j.jpeds.2018.12.022.","DOI":"10.1016\/j.jpeds.2018.12.022"},{"key":"2023033122070751538_j_jpem-2021-0691_ref_002","doi-asserted-by":"crossref","unstructured":"Cesario, SK, Hughes, LA. Precocious puberty: a comprehensive review of literature. J Obstet Gynecol Neonatal Nurs 2007;36:263\u201374. https:\/\/doi.org\/10.1111\/j.1552-6909.2007.00145.x.","DOI":"10.1111\/j.1552-6909.2007.00145.x"},{"key":"2023033122070751538_j_jpem-2021-0691_ref_003","doi-asserted-by":"crossref","unstructured":"Partsch, CJ, Sippell, WG. 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