{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:24:33Z","timestamp":1790915073932,"version":"4.1.0"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0707_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Feminizing adrenal tumors are rare in childhood. We present a case of a special category of adrenal tumor, an oncocytoma, causing isosexual peripheral precocity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0707_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 4-year old girl presented with breast development and menstrual bleeding over a period of 3\u20134\u00a0months. Her SMR staging was breast stage 4, pubic hair stage 3. Her bone\u00a0age was advanced (6\u00a0year 10\u00a0months), stimulated LH 0.7\u00a0IU\/L, estradiol 206\u00a0pmol\/L and DHEAS &gt;27.1\u00a0micromol\/L. CT scan revealed a right adrenal mass with features of atypical adrenal adenoma. Laparoscopic adrenalectomy was done and histopathology revealed oncocytoma. Lin\u2013Weiss\u2013Bisceglia criteria classified it as likely benign, borne out till a 2\u00a0year follow up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0707_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Adrenal oncocytoma can be a cause of isosexual peripheral precocity in a young girl. Recognition and correct classification of this histological variant, which is more often benign, is important for prognostication and choice of therapy after surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0707","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:12:30Z","timestamp":1646352750000},"page":"827-830","source":"Crossref","is-referenced-by-count":2,"title":["Feminizing adrenocortical oncocytoma presenting as precocious puberty: a case report and literature review"],"prefix":"10.1515","volume":"35","author":[{"given":"Sonali","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Endocrinology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Mandelia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"2023033122444469439_j_jpem-2021-0707_ref_001","doi-asserted-by":"crossref","unstructured":"Bisceglia, M, Ludovico, O, DiMattia, A, BenDor, D, Sandbank, J, Pasquinelli, G, et al.. Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol 2004;12:231\u201343, https:\/\/doi.org\/10.1177\/106689690401200304.","DOI":"10.1177\/106689690401200304"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_002","doi-asserted-by":"crossref","unstructured":"Ghazi, AA, Mofid, D, Salehian, MT, Amirbaigloo, A, Zare, K, Jafari, B, et al.. Functioning adrenocortical tumors in children-secretory behavior. J Clin Res Pediatr Endocrinol 2013;5:27\u201332, https:\/\/doi.org\/10.4274\/Jcrpe.835.","DOI":"10.4274\/Jcrpe.835"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_003","doi-asserted-by":"crossref","unstructured":"Moreno, S, Guillermo, M, Decoulx, M, Dewailly, D, Bresson, R, Proye, C, et al.. Feminizing adreno-cortical carcinomas in male adults. A\u00a0dire prognosis. Three cases in a series of 801 adrenalectomies and review of the literature. Ann Endocrinol 2006;67:32\u20138, https:\/\/doi.org\/10.1016\/s0003-4266(06)72537-9.","DOI":"10.1016\/S0003-4266(06)72537-9"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_004","doi-asserted-by":"crossref","unstructured":"Wong, DD, Spagnolo, DV, Bisceglia, M. Oncocytic adrenocortical neoplasms\u2014a clinicopathologic study of 13 new cases emphasizing the importance of their recognition. Hum Pathol 2011;42:489\u201399, https:\/\/doi.org\/10.1016\/j.humpath.2010.08.010.","DOI":"10.1016\/j.humpath.2010.08.010"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_005","doi-asserted-by":"crossref","unstructured":"Saad, R, Marsault, S, Coloby, P. Adrenocortical oncocytic cells tumor: case report and review of literature. Prog Urol 2011;21:288\u201390, https:\/\/doi.org\/10.1016\/j.purol.2010.04.005.","DOI":"10.1016\/j.purol.2010.04.005"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_006","doi-asserted-by":"crossref","unstructured":"Dong, D, Liu, X, Ji, Z, Li, H. Diagnosis and treatment of adrenocortical oncocytoma: case report of five cases and review of the literature. Front Oncol 2019;9:338, https:\/\/doi.org\/10.3389\/fonc.2019.00338.","DOI":"10.3389\/fonc.2019.00338"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_007","doi-asserted-by":"crossref","unstructured":"Balakumar, T, Perry, LA, Savage, MO. Adrenocortical adenoma\u2013an unusual presentation with hypersecretion of oestradiol, androgens and cortisol. J Pediatr Endocrinol Metab 1997;10:227\u20139, https:\/\/doi.org\/10.1515\/jpem.1997.10.2.227.","DOI":"10.1515\/JPEM.1997.10.2.227"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_008","doi-asserted-by":"crossref","unstructured":"McKenna, TJ, O\u2019Connell, Y, Cunningham, S, McCabe, M, Culliton, M. Steroidogenesis in an estrogen-producing adrenal tumor in a young woman: comparison with steroid profiles associated with cortisol- and androgen-producing tumors. J Clin Endocrinol Metab 1990;70:28\u201334, https:\/\/doi.org\/10.1210\/jcem-70-1-28.","DOI":"10.1210\/jcem-70-1-28"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_009","doi-asserted-by":"crossref","unstructured":"Minagawa, M, Wataki, K, Matsunaga, T, Ohnuma, N, Kohno, Y, Harada, N. Estrogen secreting adrenal adenocarcinoma in an 18\u00a0month-old boy: aromatase activity, protein expression, mRNA and utilization of gonadal type promoter. Endocr J 2000;47:723\u201330.","DOI":"10.1507\/endocrj.47.723"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_010","doi-asserted-by":"crossref","unstructured":"Schittenhelm, J, Ebner, FH, Harter, P, Bornemann, A. Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol 2009;20:73\u20137, https:\/\/doi.org\/10.1007\/s12022-008-9051-1.","DOI":"10.1007\/s12022-008-9051-1"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_011","doi-asserted-by":"crossref","unstructured":"Wieneke, JA, Thompson, LDR, Heffess, CS. Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. Am J Surg Pathol 2003;27:867\u201381, https:\/\/doi.org\/10.1097\/00000478-200307000-00001.","DOI":"10.1097\/00000478-200307000-00001"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_012","doi-asserted-by":"crossref","unstructured":"Das, S, Sengupta, M, Islam, N, Roy, P, Datta, C, Mishra, PK, et al.. Weineke criteria, Ki-67 index and p53 status to study pediatric adrenocortical tumors: is there a correlation? J Pediatr Surg 2016;51:1795\u2013800, https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.07.014.","DOI":"10.1016\/j.jpedsurg.2016.07.014"},{"key":"2023033122444469439_j_jpem-2021-0707_ref_013","doi-asserted-by":"crossref","unstructured":"Picard, C, Orbach, D, Carton, M, Brugieres, L, Renaudin, K, Aubert, S, et al.. Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological review. Mod Pathol 2019;32:546\u201359, https:\/\/doi.org\/10.1038\/s41379-018-0174-8.","DOI":"10.1038\/s41379-018-0174-8"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0707\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0707\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T12:11:34Z","timestamp":1680351094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2021-0707\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,4,20]]},"published-print":{"date-parts":[[2022,6,27]]}},"alternative-id":["10.1515\/jpem-2021-0707"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2021-0707","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]}}}