{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:43:05Z","timestamp":1775976185813,"version":"3.50.1"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0721_abs_001\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Babies born small for gestational age (SGA) are at risk of obesity and metabolic syndrome (MetS). Spexin (SPX) is a novel peptide implicated in food intake and obesity. Spexin levels are lower in obese subjects. This study investigated the potential association of SPX and some obesity related peptides such as leptin and active ghrelin with size at birth and MetS components in prepubertal children born term and either SGA or appropriate for GA (AGA). Secondary aim was to identify whether any of the investigated peptides were associated with MetS components.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0721_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a cross-sectional study of 37 consecutive (median age: 5.6\u00a0y) SGA- and 50 (median age: 5.9\u00a0y) AGA-born children. Clinical evaluations were performed using standard methods. Several biochemical variables (SPX, total leptin, and active ghrelin levels) were analyzed. Age-dependent cut-off values were used to define MetS components, including excess adiposity, hypertension, insulin resistance, and dyslipidemia. The associations between the assessed clinical and laboratory variables and MetS components were investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0721_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Children born SGA had higher frequencies of MetS components than AGA-born peers (p\u00a0&lt;\u00a00.01). None of the investigated peptides were different between children born SGA and AGA after correcting for body mass index (p\u00a0&gt;\u00a00.05 for all). Serum SPX levels were lower in children with at least one metS component than those without MetS components (p\u00a0=\u00a00.018).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0721_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Size at birth had no association with serum SPX. Serum SPX levels are decreased in prepubertal children with MetS components.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0721","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T19:35:15Z","timestamp":1648236915000},"page":"649-655","source":"Crossref","is-referenced-by-count":3,"title":["Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term"],"prefix":"10.1515","volume":"35","author":[{"given":"Fatma Duygu","family":"\u00d6zt\u00fcrk \u00d6nsal","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Well-Child Care Clinic , University of Health Sciences, \u015ei\u015fli Hamidiye Etfal Education & Research Hospital , Istanbul , Turkey"},{"name":"Department of Pediatric Endocrinology & Diabetes , University of Health Sciences, \u015ei\u015fli Hamidiye Etfal Education & Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gizem Kara","family":"Elitok","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Well-Child Care Clinic , University of Health Sciences, \u015ei\u015fli Hamidiye Etfal Education & Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Well-Child Care Clinic , University of Health Sciences, \u015ei\u015fli Hamidiye Etfal Education & Research Hospital , Istanbul , Turkey"},{"name":"Department of Neonatology , University of Health Sciences, \u015ei\u015fli Hamidiye Etfal Education & Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"U\u00e7ar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology & Diabetes , University of Health Sciences, \u015ei\u015fli Hamidiye Etfal Education & Research Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"2023033121124484341_j_jpem-2021-0721_ref_001","doi-asserted-by":"crossref","unstructured":"Bereket, A, Atay, Z. 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