{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:52:25Z","timestamp":1762876345608,"version":"3.40.5"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2021-0727_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>It has been hypothesized that SARS-CoV-2 may play a role in the development of different forms of diabetes mellitus (DM). The Canary Islands have the highest incidence of type 1 DM (T1DM) reported in Spain\u00a0(30\u201335\/100,000 children under 14 years\/year). In 2020\u20132021 we observed the highest incidence so far on the island of Gran Canaria, as a result of which we decided to evaluate the possible role of COVID-19 in the increased number of onsets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0727_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We examined the presence of IgG antibodies against SARS-CoV-2 in children with new onset T1DM between October 2020 and August 2021. We compared recent T1DM incidence with that of the previous 10 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0727_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-two patients were diagnosed with T1DM (48.1\/100,000 patients\/year), representing a nonsignificant 25.7% increase from the expected incidence. Of the 33\u00a0patients who consented to the study, 32 presented negative IgG values, with only one patient reflecting undiagnosed past infection. Forty-four percent of patients presented with ketoacidosis at onset, which was similar to previous years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2021-0727_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We conclude that there is no direct relationship between the increased incidence of T1DM and SARS-CoV-2 in the region. The COVID-19 pandemic did not result in an increased severity of T1DM presentation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2021-0727","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:51:22Z","timestamp":1642121482000},"source":"Crossref","is-referenced-by-count":6,"title":["Role of the SARS-CoV-2 virus in the appearance of new onset type 1 diabetes mellitus in children in Gran Canaria, Spain"],"prefix":"10.1515","volume":"0","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-0654","authenticated-orcid":false,"given":"Yeray","family":"N\u00f3voa-Medina","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"},{"name":"Asociaci\u00f3n Canaria para la Investigaci\u00f3n Pedi\u00e1trica (ACIP canarias) , Canary Islands , Spain"},{"name":"Instituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias (IUIBS) , Universidad de Las Palmas de Gran Canaria (ULPGC) , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Pavlovic-Nesic","sequence":"additional","affiliation":[{"name":"Pediatric Department , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Ma","family":"Gonz\u00e1lez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Research Unit , University Hospital Dr.\u00a0Negr\u00edn, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"Hern\u00e1ndez-Betancor","sequence":"additional","affiliation":[{"name":"Microbiology Department , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Dom\u00ednguez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Quinteiro-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"De La Cuesta","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Caballero-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda A.","family":"Gonz\u00e1lez-Perera","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"De Miguel-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Microbiology Department , Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de GC , Canary Islands , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham D.","family":"Ogle","sequence":"additional","affiliation":[{"name":"Life for a Child Program , Diabetes NSW & ACT , Sydney , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"W\u00e4gner","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias (IUIBS) , Universidad de Las Palmas de Gran Canaria (ULPGC) , Canary 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