{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T01:51:48Z","timestamp":1782611508362,"version":"3.54.5"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0001_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Diabetes mellitus (DM) is widely known to have a detrimental effect on bone health and is associated with increased fracture risk. Recently, the Wnt\/beta-catenin signaling pathway and its inhibitors sclerostin and dickkopf-1 (Dkk-1) were found to be involved in the control of bone mass. The present study aimed to measure serum sclerostin and Dkk-1 protein levels in children and adolescents with type-1 DM and compare with other bone turnover markers and bone mineral density (BMD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0001_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study was performed on 40 children and adolescents with type-I DM and 40 healthy children and adolescents. Anthropometric measurements and pubertal examination were done. In addition to laboratory analysis, dickkopf-1, sclerostin, cross-linked N-telopeptides of type I collagen (NTx), bone alkaline phosphatase (bALP), and osteocalcin levels were studied. BMD of the participants was measured by calcaneus ultrasonography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0001_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Dickkopf-1 levels of the children and adolescents with type-1 DM were significantly higher, vitamin D, NTx, osteocalcin, and phosphorus levels were significantly lower than those of the controls (p&lt;0.001). Fasting blood glucose, HbA1c, and insulin were significantly higher in the type 1 DM group (p&lt;0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0001_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both bone remodeling and its compensatory mechanism bone loss are lower in children and adolescents with type-1 DM than in the controls. Also, higher levels of Dkk-1 play a role in decreased bone turnover in these patients. Since Dkk-1 and sclerostin seem to take a role in treating metabolic bone diseases in the future, we believe that our findings are significant in this respective.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0001","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T07:40:56Z","timestamp":1649749256000},"page":"673-679","source":"Crossref","is-referenced-by-count":13,"title":["Investigation of the relationship between serum sclerostin and dickkopf-1 protein levels with bone turnover in children and adolescents with type-1 diabetes mellitus"],"prefix":"10.1515","volume":"35","author":[{"given":"Sevil","family":"Kurban","sequence":"first","affiliation":[{"name":"Department of Biochemistry , Necmettin Erbakan University Faculty of Medicine , Konya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-5346","authenticated-orcid":false,"given":"Beray","family":"Selver Eklioglu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Necmettin Erbakan University Faculty of Medicine , Konya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Burak","family":"Selver","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Necmettin Erbakan University Faculty of Medicine , Konya , Turkey"},{"name":"Istanbul University, Institute of Health Sciences and Institute of Child Health Social Pediatrics PhD Program , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"2023033121124482700_j_jpem-2022-0001_ref_001","doi-asserted-by":"crossref","unstructured":"Bonjour, JP, Ammann, P, Rizzoli, R. 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