{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:58:18Z","timestamp":1757541498881,"version":"3.40.5"},"reference-count":51,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0197_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Children with epilepsy are at increased risk of vitamin D deficiency. We aimed to compare the effect of\u00a0two ergocalciferol regimens given for 90\u00a0days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0197_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Epileptic patients aged 5\u201318\u00a0years who received at least one antiepileptic drug (AED) for more than 6\u00a0months and had serum 25-OHD &lt;30\u00a0ng\/mL were randomized to receive 20,000\u00a0IU\/10\u00a0d (standard dose, n=41) or 60,000\u00a0IU\/10\u00a0d (high dose, n=41) of oral ergocalciferol. Serum Ca, P, Mg, ALP, iPTH and urine Ca\/Cr ratio were measured at baseline and after 90\u00a0days of treatment. Change in serum 25-OHD and vitamin D status after treatment was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0197_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The initial serum 25-OHD in the standard dose and high dose group was 19.5\u00a0\u00b1\u00a04.9 and 18.4\u00a0\u00b1\u00a04.6\u00a0ng\/mL, respectively. Serum 25-OHD after treatment was significantly higher in the high dose group (39.0\u00a0\u00b1\u00a011.5 vs. 27.5\u00a0\u00b1\u00a08.6\u00a0ng\/mL, p&lt;0.05). The average increase in serum 25-OHD in the high dose and standard dose group was 20.6\u00a0\u00b1\u00a011.4 and 7.2\u00a0\u00b1\u00a07.5\u00a0ng\/mL, respectively (p&lt;0.05). Normalized serum 25-OHD was achieved in 80.5% of the\u00a0high dose group compared to 36.6% of the standard dose group (p&lt;0.05). No adverse events were found. Patients with a BMI Z-score&gt;0 had a 2.5 times greater risk of\u00a0continued hypovitaminosis D after treatment compared to those with a BMI Z-score&lt;0 (95% CI: 1.0\u20135.9, p&lt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0197_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Oral ergocalciferol 60,000\u00a0IU\/10\u00a0d for 90\u00a0days was more effective at normalizing serum 25-OHD than 20,000\u00a0IU\/10\u00a0d in epileptic children and adolescents who were receiving AEDs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0197","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T14:35:31Z","timestamp":1664807731000},"page":"1369-1376","source":"Crossref","is-referenced-by-count":2,"title":["Standard and high dose ergocalciferol regimens for treatment of hypovitaminosis D in epileptic children and adolescents"],"prefix":"10.1515","volume":"35","author":[{"given":"Suchavadee","family":"Vichutavate","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics , Phramongkutklao Hospital and College of Medicine , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piradee","family":"Suwanpakdee","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics , Phramongkutklao Hospital and College of Medicine , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Napakjira","family":"Likasitthananon","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics , Phramongkutklao Hospital and College of Medicine , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawaporn","family":"Numbenjapon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics , Phramongkutklao Hospital and College of Medicine , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charcrin","family":"Nabangchang","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics , Phramongkutklao Hospital and College of Medicine , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-083X","authenticated-orcid":false,"given":"Voraluck","family":"Phatarakijnirund","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics , Phramongkutklao Hospital and College of Medicine , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"2023040100342183929_j_jpem-2022-0197_ref_001","doi-asserted-by":"crossref","unstructured":"Holick, MF, Chen, TC. 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