{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:43:35Z","timestamp":1764020615502,"version":"3.40.5"},"reference-count":6,"publisher":"Walter de Gruyter GmbH","issue":"12","funder":[{"name":"The Foundation for Growth Science","award":["2021 research grant"],"award-info":[{"award-number":["2021 research grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0224_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The usefulness of continuous glucose monitoring (CGM) in infants with panhypopituitarism (PH) having hypoglycemia is yet to be explored. The potential adverse effects of growth hormone (GH) replacement therapy, such as hyperglycemia, cannot be comprehensively evaluated using the conventional measurement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0224_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 2-month-old infant with PH, including severe GH deficiency, had hypoglycemia despite frequent feeding. Glucose levels were monitored using CGM before and after GH replacement therapy. The proportion of time for hypoglycemia decreased from 4.9 to 0% (p&lt;0.017). Hyperglycemia did not increase. The CGM method did not contribute to any adverse events requiring intervention. Our patient only experienced minor bleeding and no episode of cellulitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0224_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CGM is useful in controlling glucose levels in infants with hypoglycemia and PH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0224","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T01:05:36Z","timestamp":1663376736000},"page":"1556-1559","source":"Crossref","is-referenced-by-count":4,"title":["Continuous glucose monitoring in an infant with panhypopituitarism having hypoglycemia on growth hormone therapy"],"prefix":"10.1515","volume":"35","author":[{"given":"Kaho","family":"Kiuchi","sequence":"first","affiliation":[{"name":"Keio University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-2975","authenticated-orcid":false,"given":"Takeshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satsuki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-2465","authenticated-orcid":false,"given":"Tomohiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonobu","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"2023040100361112929_j_jpem-2022-0224_ref_001","doi-asserted-by":"crossref","unstructured":"Watanabe, T, Ozawa, A, Ishii, S, Tomaru, T, Shibusawa, N, Saito, T, et al.. Usage of continuous glucose monitoring (CGM) for detecting an unrecognized hypoglycemia and management of glucocorticoid replacement therapy in adult patients with central hypoadrenalism. Endocr J 2018;65:547\u201356. https:\/\/doi.org\/10.1507\/endocrj.ej16-0387.","DOI":"10.1507\/endocrj.EJ16-0387"},{"key":"2023040100361112929_j_jpem-2022-0224_ref_002","doi-asserted-by":"crossref","unstructured":"Christiansen, MP, Garg, SK, Brazg, R, Bode, BW, Bailey, TS, Slover, RH, et al.. Accuracy of a fourth-generation subcutaneous continuous glucose sensor. Diabetes Technol Therapeut 2017;19:446\u201356. https:\/\/doi.org\/10.1089\/dia.2017.0087.","DOI":"10.1089\/dia.2017.0087"},{"key":"2023040100361112929_j_jpem-2022-0224_ref_003","doi-asserted-by":"crossref","unstructured":"Shah, R, McKinlay, CJD, Harding, JE. Neonatal hypoglycemia: continuous glucose monitoring. Curr Opin Pediatr 2018;30:204\u20138. https:\/\/doi.org\/10.1097\/mop.0000000000000592.","DOI":"10.1097\/MOP.0000000000000592"},{"key":"2023040100361112929_j_jpem-2022-0224_ref_004","doi-asserted-by":"crossref","unstructured":"Agus, MS, Wypij, D, Hirshberg, EL, Srinivasan, V, Faustino, EV, Luckett, PM, et al.. Tight glycemic control in critically ill children. N Engl J Med 2017;376:729\u201341. https:\/\/doi.org\/10.1056\/nejmoa1612348.","DOI":"10.1056\/NEJMoa1612348"},{"key":"2023040100361112929_j_jpem-2022-0224_ref_005","doi-asserted-by":"crossref","unstructured":"Hirshberg, EL, Sward, KA, Faustino, EV, Nadkarni, VM, Agus, MS, Morris, AH, et al.. Clinical equipoise regarding glycemic control: a survey of pediatric intensivist perceptions. Pediatr Crit Care Med 2013;14:123\u20139. https:\/\/doi.org\/10.1097\/pcc.0b013e31826049b3.","DOI":"10.1097\/PCC.0b013e31826049b3"},{"key":"2023040100361112929_j_jpem-2022-0224_ref_006","doi-asserted-by":"crossref","unstructured":"Win, M, Beckett, R, Thomson, L, Thankamony, A, Beardsall, K. Continuous glucose monitoring in the management of neonates with persistent hypoglycemia and congenital hyperinsulinism. J Clin Endocrinol Metab 2022;107:e246\u201353. https:\/\/doi.org\/10.1210\/clinem\/dgab601.","DOI":"10.1210\/clinem\/dgab601"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0224\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0224\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T15:52:42Z","timestamp":1680364362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0224\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":6,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,11,30]]},"published-print":{"date-parts":[[2022,12,16]]}},"alternative-id":["10.1515\/jpem-2022-0224"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2022-0224","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"type":"print","value":"0334-018X"},{"type":"electronic","value":"2191-0251"}],"subject":[],"published":{"date-parts":[[2022,9,19]]}}}