{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:13:42Z","timestamp":1756462422821,"version":"3.40.5"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0368_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Large cell calcifying Sertoli cell tumours (LCCSCTs) are one of the infrequent causes of prepubertal gynaecomastia. Most of these tumours are in the content of Peutz\u2013Jeghers syndrome (PJS) or other familial syndromes (Carney complex).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0368_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>Here, we report a long-term follow-up of an 8.5-year-old prepubertal boy with a diagnosis of PJS, who presented with bilateral gynaecomastia, advanced bone age and accelerated growth velocity, and were found to have bilateral multifocal testicular microcalcifications. As the findings were compatible with LCCSCT, anastrozole was initiated. Gynaecomastia completely regressed and growth velocity and pubertal development were appropriate for age during follow-up. Testicular lesions slightly increased in size. After four\u00a0years of medication, anastrozole was discontinued but was restarted due to the recurrence of gynaecomastia after six\u00a0months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0368_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Testicular tumour should be investigated in a patient with PJS who presents with prepubertal gynaecomastia. When findings are consistent with LCCSCT, aromatase inhibitors may be preferred in the treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0368","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T06:50:24Z","timestamp":1664607024000},"page":"1565-1570","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of aromatase inhibitor therapy in a case with large cell calcifying Sertoli cell tumour-associated prepubertal gynaecomastia"],"prefix":"10.1515","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-9002","authenticated-orcid":false,"given":"G\u00f6zde Ak\u0131n","family":"Ka\u011f\u0131zmanl\u0131","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-9617","authenticated-orcid":false,"given":"\u00d6zge","family":"Besci","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9492-4834","authenticated-orcid":false,"given":"K\u00fcbra Y\u00fcksek","family":"Acinikli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-4978","authenticated-orcid":false,"given":"G\u00fcl","family":"\u015eeker","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-1044","authenticated-orcid":false,"given":"Elif","family":"Ya\u015far","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-7815","authenticated-orcid":false,"given":"Ye\u015fim","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-2422","authenticated-orcid":false,"given":"Korcan","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-0892","authenticated-orcid":false,"given":"Ece","family":"B\u00f6ber","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-0321","authenticated-orcid":false,"given":"Ayhan","family":"Abac\u0131","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology , Dokuz Eyl\u00fcl University Faculty of Medicine , \u0130zmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2023040100361107560_j_jpem-2022-0368_ref_001","doi-asserted-by":"crossref","unstructured":"Narula, HS, Carlson, HE. 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