{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:51:04Z","timestamp":1747198264720,"version":"3.40.5"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Betamethasone causing iatrogenic Cushing\u2019s syndrome (CS) in infants are rarely reported.<\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n \u2217 In this case report, there were severe signs of CS, such as considerable weight acceleration and concurrent height deceleration, hirsutism and ecchymosis of the face, and buffalo pad, which are often found in adults. \u2217 Clobetasol propionate, diflucortolone valerate, and dexamethasone nasal sprays were used in the majority of previously reported cases of corticosteroid abuse, whereas this is the first case of CS in an infant as a result of the use of betamethasone cream, also known as betnesol, which is frequently used by mothers in developing countries as a treatment for rashes. \u2217 In this instance, a severe medication interaction caused by systemic betamethasone cream buildup led to the creation of CS. For the professionals, these patients are a challenge because of drug use without prescription.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Topical corticosteroid usage puts infants at risk for CS. Because of excessive betamethasone treatment in this child with diaper dermatitis, he acquired CS. It is said to draw attention to the risks of self-medication in developing nations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jpem-2022-0415","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:50:26Z","timestamp":1676440226000},"source":"Crossref","is-referenced-by-count":2,"title":["BETAMETHASONE cream to treat diapers rash causing Cushing syndrome"],"prefix":"10.1515","volume":"0","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1867-943X","authenticated-orcid":false,"given":"Tooba","family":"Ali","sequence":"first","affiliation":[{"name":"Dow University of Health Sciences , Karachi , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-0212","authenticated-orcid":false,"given":"Ashna","family":"Habib","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences , Karachi , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Zohair","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences , Karachi , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna","family":"Aman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology , National Institute of Child Health , Karachi , Sindh , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"2023021505502366014_j_jpem-2022-0415_ref_001","doi-asserted-by":"crossref","unstructured":"Ahmed, SM, Ahmed, SF, Othman, S, Abdulla, BA, Mohammed, SH, Salih, AM, et al.. Topical corticosteroid-induced iatrogenic cushing syndrome in an infant; a case report with literature review. Ann Med Surg 2021;71:102978. https:\/\/doi.org\/10.1016\/j.amsu.2021.102978.","DOI":"10.1016\/j.amsu.2021.102978"},{"key":"2023021505502366014_j_jpem-2022-0415_ref_002","doi-asserted-by":"crossref","unstructured":"Ahmed, SF, Bapir, R, Fattah, FH, Mahmood, AG, Salih, RQ, Salih, AM, et al.. Simultaneous pituitary and adrenal adenomas in a patient with non ACTH dependent Cushing syndrome; a case report with literature review. Int J Surg Case Rep 2022;94:107038. https:\/\/doi.org\/10.1016\/j.ijscr.2022.107038.","DOI":"10.1016\/j.ijscr.2022.107038"},{"key":"2023021505502366014_j_jpem-2022-0415_ref_003","doi-asserted-by":"crossref","unstructured":"Tiwari, A, Goel, M, Pal, P, Gohiya, P. Topical-steroid-induced iatrogenic Cushing syndrome in the paediatric age group: a rare case report. Indian J Endocrinol Metab 2013;17:S257\u20138. https:\/\/doi.org\/10.4103\/2230-8210.119593.","DOI":"10.4103\/2230-8210.119593"},{"key":"2023021505502366014_j_jpem-2022-0415_ref_004","unstructured":"Jevalikar, G, Sharma, O. Exogenous cushing syndrome due to topical clobetasone use for diaper rash. Indian Pediatr 2016;53:76\u20137."},{"key":"2023021505502366014_j_jpem-2022-0415_ref_005","doi-asserted-by":"crossref","unstructured":"Blume-Peytavi, U, Kanti, V. Prevention and treatment of diaper dermatitis. Pediatr Dermatol 2018;35:s19\u201323. https:\/\/doi.org\/10.1111\/pde.13495.","DOI":"10.1111\/pde.13495"},{"key":"2023021505502366014_j_jpem-2022-0415_ref_006","doi-asserted-by":"crossref","unstructured":"Rajan, R, Kuriakose, C, Paul, J, Kapoor, N, Cherian, KE, Paul, TV. A rare cause of familial exogenous Cushing syndrome. J Fam Med Prim Care 2019;8:1798\u2013800. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_294_19.","DOI":"10.4103\/jfmpc.jfmpc_294_19"},{"key":"2023021505502366014_j_jpem-2022-0415_ref_007","doi-asserted-by":"crossref","unstructured":"Ohnishi, T, Suzuki, T, Watanabe, S, Takahashi, H. Erythrodermic psoriasis associated with hyperuricemia and Iatrogenic Cushing\u2019s syndrome due to topical corticosteroid therapy. Int J Dermatol 1996;35:379\u201380. https:\/\/doi.org\/10.1111\/j.1365-4362.1996.tb03647.x.","DOI":"10.1111\/j.1365-4362.1996.tb03647.x"},{"key":"2023021505502366014_j_jpem-2022-0415_ref_008","doi-asserted-by":"crossref","unstructured":"Alkhuder, L, Mawlawi, H. Infantile iatrogenic cushing syndrome due to topical steroids. Case Rep Pediatr 2019;2019:2652961. https:\/\/doi.org\/10.1155\/2019\/2652961.","DOI":"10.1155\/2019\/2652961"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0415\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0415\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:50:35Z","timestamp":1676440235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0415\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":8,"journal-issue":{"issue":"0","published-online":{"date-parts":[[2023,2,16]]}},"alternative-id":["10.1515\/jpem-2022-0415"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2022-0415","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"type":"print","value":"0334-018X"},{"type":"electronic","value":"2191-0251"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}