{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:50:40Z","timestamp":1775044240433,"version":"3.50.1"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0525_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>There have been recent advances assessing copeptin levels in adults with suspected disorders of vasopressin release. Very limited data exits on copeptin levels in children and infants, especially in a critically-ill hospitalized population where hyper- and hypo-natremia are very common. Our objective is to describe the institutional experience assessing copeptin levels in hospitalized infants and children with hyper- or hypo-natremia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0525_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a single-center retrospective case series of all infants, children, and adolescents who had an ultrasensitive plasma copeptin level obtained between 2019-2021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0525_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 29 critically ill patients (6 infants) were identified with 38\u00a0% of patients having copeptin levels after neurosurgical procedures for tumors or trauma. Approximately 13\/17 children with hypernatremia had central diabetes insipidus (central diabetes insipidus) to diagnose CDI, A copeptin level\u00a0\u2264 4.9\u00a0pmol\/L resulted in an 88\u00a0% sensitivity (95\u00a0% CI 47\u201399\u00a0%), and 66\u00a0% specificity (95\u00a0% CI 30\u201393\u00a0%). Amongst those with hyponatremia levels were more variable, 8\/12 children had syndrome of inappropriate antidiuresis (SIAD) with copeptin levels ranging 4.7\u201372.6\u00a0pmol\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0525_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>While difficult to conclude due to multiple limitations, this case series highlights that typical copeptin cutoffs used to diagnose DI in adults in an ambulatory setting may also translate to a critically-ill pediatric population. Large prospective studies are needed to confirm this observation. In addition, postoperative copeptin levels could potentially be utilized as an additional marker to predict permanent from transient DI, but much larger studies are needed. Further work is needed to establish normative copeptin levels in infants and patients with SIAD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0525","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T14:35:37Z","timestamp":1680964537000},"page":"492-499","source":"Crossref","is-referenced-by-count":7,"title":["Copeptin levels in hospitalized infants and children with suspected vasopressin-dependent disorders: a case series"],"prefix":"10.1515","volume":"36","author":[{"given":"Alaa","family":"Al Nofal","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology and Metabolism , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hanna","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology and Hypertension , Mayo Clinic , Rochester , USA"},{"name":"Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida N.","family":"Lteif","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Metabolism , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobhan T.","family":"Pittock","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Metabolism , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E.","family":"Brumbaugh","sequence":"additional","affiliation":[{"name":"Division of Neonatal Medicine , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-1800","authenticated-orcid":false,"given":"Ana L.","family":"Creo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Metabolism , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"2023050204214810376_j_jpem-2022-0525_ref_001","doi-asserted-by":"crossref","unstructured":"Driano, JE, Lteif, AN, Creo, AL. Vasopressin-dependent disorders: what is new in children? Pediatrics 2021;147:e2020022848. https:\/\/doi.org\/10.1542\/peds.2020-022848.","DOI":"10.1542\/peds.2020-022848"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_002","doi-asserted-by":"crossref","unstructured":"Fenske, W, Quinkler, M, Lorenz, D, Zopf, K, Haagen, U, Papassotiriou, J, et al.. Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests. J Clin Endocrinol Metab 2011;96:1506\u201315. https:\/\/doi.org\/10.1210\/jc.2010-2345.","DOI":"10.1210\/jc.2010-2345"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_003","doi-asserted-by":"crossref","unstructured":"Refardt, J, Winzeler, B, Christ-Crain, M. Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis. Clin Endocrinol 2019;91:22\u201332. https:\/\/doi.org\/10.1111\/cen.13991.","DOI":"10.1111\/cen.13991"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_004","doi-asserted-by":"crossref","unstructured":"Morgenthaler, NG, Struck, J, Jochberger, S, Dunser, MW. Copeptin: clinical use of a new biomarker. Trends Endocrinol Metabol 2008;19:43\u20139. https:\/\/doi.org\/10.1016\/j.tem.2007.11.001.","DOI":"10.1016\/j.tem.2007.11.001"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_005","doi-asserted-by":"crossref","unstructured":"Fenske, W, Refardt, J, Chifu, I, Schnyder, I, Winzeler, B, Drummond, J, et al.. A\u00a0copeptin-based approach in the diagnosis of diabetes insipidus. N Engl J Med 2018;379:428\u201339. https:\/\/doi.org\/10.1056\/nejmoa1803760.","DOI":"10.1056\/NEJMoa1803760"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_006","doi-asserted-by":"crossref","unstructured":"Nickel, CH, Bingisser, R, Morgenthaler, NG. The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department. BMC Med 2012;10:7. https:\/\/doi.org\/10.1186\/1741-7015-10-7.","DOI":"10.1186\/1741-7015-10-7"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_007","doi-asserted-by":"crossref","unstructured":"Christ-Crain, M, Fenske, WK. Copeptin in the differential diagnosis of hypotonic polyuria. J Endocrinol Invest 2020;43:21\u201330. https:\/\/doi.org\/10.1007\/s40618-019-01087-6.","DOI":"10.1007\/s40618-019-01087-6"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_008","doi-asserted-by":"crossref","unstructured":"Morgenthaler, NG, Struck, J, Alonso, C, Bergmann, A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 2006;52:112\u20139. https:\/\/doi.org\/10.1373\/clinchem.2005.060038.","DOI":"10.1373\/clinchem.2005.060038"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_009","doi-asserted-by":"crossref","unstructured":"Bhandari, SS, Loke, I, Davies, JE, Squire, IB, Struck, J, Ng, LL. Gender and renal function influence plasma levels of copeptin in healthy individuals. Clin Sci 2009;116:257\u201363. https:\/\/doi.org\/10.1042\/cs20080140.","DOI":"10.1042\/CS20080140"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_010","doi-asserted-by":"crossref","unstructured":"Timper, K, Fenske, W, Kuhn, F, Frech, N, Arici, B, Rutishauser, J, et al.. Diagnostic accuracy of copeptin in the differential diagnosis of the polyuria-polydipsia syndrome: a prospective multicenter study. J Clin Endocrinol Metab 2015;100:2268\u201374. https:\/\/doi.org\/10.1210\/jc.2014-4507.","DOI":"10.1210\/jc.2014-4507"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_011","doi-asserted-by":"crossref","unstructured":"Boursier, G, Almeras, M, Buthiau, D, Jugant, S, Daubin, D, Kuster, N, et al.. CT-pro-AVP as a tool for assessment of intravascular volume depletion in severe hyponatremia. Clin Biochem 2015;48:640\u20135. https:\/\/doi.org\/10.1016\/j.clinbiochem.2015.03.013.","DOI":"10.1016\/j.clinbiochem.2015.03.013"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_012","doi-asserted-by":"crossref","unstructured":"Fenske, W, Stork, S, Blechschmidt, A, Maier, SG, Morgenthaler, NG, Allolio, B. Copeptin in the differential diagnosis of hyponatremia. J Clin Endocrinol Metab 2009;94:123\u20139. https:\/\/doi.org\/10.1210\/jc.2008-1426.","DOI":"10.1210\/jc.2008-1426"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_013","doi-asserted-by":"crossref","unstructured":"Nigro, N, Winzeler, B, Suter-Widmer, I, Schuetz, P, Arici, B, Bally, M, et al.. Evaluation of copeptin and commonly used laboratory parameters for the differential diagnosis of profound hyponatraemia in hospitalized patients: \u2019The Co-MED Study. Clin Endocrinol 2017;86:456\u201362. https:\/\/doi.org\/10.1111\/cen.13243.","DOI":"10.1111\/cen.13243"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_014","doi-asserted-by":"crossref","unstructured":"Bonnet, L, Marquant, E, Fromonot, J, Hamouda, I, Berbis, J, Godefroy, A, et al.. Copeptin assays in children for the differential diagnosis of polyuria-polydipsia syndrome and reference levels in hospitalized children. Clin Endocrinol 2022;96:47\u201353. https:\/\/doi.org\/10.1111\/cen.14620.","DOI":"10.1111\/cen.14620"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_015","doi-asserted-by":"crossref","unstructured":"Du, JM, Sang, G, Jiang, CM, He, XJ, Han, Y. Relationship between plasma copeptin levels and complications of community-acquired pneumonia in preschool children. Peptides 2013;45:61\u20135. https:\/\/doi.org\/10.1016\/j.peptides.2013.04.015.","DOI":"10.1016\/j.peptides.2013.04.015"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_016","doi-asserted-by":"crossref","unstructured":"Tuli, G, Tessaris, D, Einaudi, S, Matarazzo, P, De Sanctis, L. Copeptin role in polyuria-polydipsia syndrome differential diagnosis and reference range in paediatric age. Clin Endocrinol 2018;88:873\u20139. https:\/\/doi.org\/10.1111\/cen.13583.","DOI":"10.1111\/cen.13583"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_017","doi-asserted-by":"crossref","unstructured":"Burckhardt, MA, Wellmann, M, Fouzas, S, Lapaire, O, Burkhardt, T, Benzing, J, et al.. Sexual disparity of copeptin in healthy newborn infants. J Clin Endocrinol Metab 2014;99:E1750\u20133. https:\/\/doi.org\/10.1210\/jc.2014-2244.","DOI":"10.1210\/jc.2014-2244"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_018","doi-asserted-by":"crossref","unstructured":"Rouatbi, H, Zigabe, S, Gkiougki, E, Vranken, L, Van Linthout, C, Seghaye, MC. Biomarkers of neonatal stress assessment: a prospective study. Early Hum Dev 2019;137:104826. https:\/\/doi.org\/10.1016\/j.earlhumdev.2019.104826.","DOI":"10.1016\/j.earlhumdev.2019.104826"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_019","doi-asserted-by":"crossref","unstructured":"Wellmann, S, Koslowski, A, Spanaus, K, Zimmermann, R, Burkhardt, T. Fetal release of copeptin in response to maternal oxytocin administration: a randomized controlled trial. Obstet Gynecol 2016;128:699\u2013703. https:\/\/doi.org\/10.1097\/aog.0000000000001594.","DOI":"10.1097\/AOG.0000000000001594"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_020","doi-asserted-by":"crossref","unstructured":"Benzing, J, Wellmann, S, Achini, F, Letzner, J, Burkhardt, T, Beinder, E, et al.. Plasma copeptin in preterm infants: a highly sensitive marker of fetal and neonatal stress. J Clin Endocrinol Metab 2011;96:E982\u20135. https:\/\/doi.org\/10.1038\/pr.2011.514.","DOI":"10.1210\/jc.2010-2858"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_021","doi-asserted-by":"crossref","unstructured":"Bitencourt, L, Fischer, BL, de Oliveira Campos, JL, Vaz de Castro, PAS, Soares de Brito, SBC, Versiani, CM, et al.. The usefulness of copeptin for the diagnosis of nephrogenic diabetes insipidus in infancy: a case report. J Pediatr Endocrinol Metab 2021;34:1475\u20139. https:\/\/doi.org\/10.1515\/jpem-2021-0296.","DOI":"10.1515\/jpem-2021-0296"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_022","doi-asserted-by":"crossref","unstructured":"Drummond, JB, Soares, BS, Pedrosa, W, Vieira, ELM, Teixeira, AL, Christ-Crain, M, et al.. Copeptin response to hypoglycemic stress is linked to prolactin activation in children. Pituitary 2020;23:681\u201390. https:\/\/doi.org\/10.1007\/s11102-020-01076-6.","DOI":"10.1007\/s11102-020-01076-6"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_023","doi-asserted-by":"crossref","unstructured":"Boal, RL, Hughes, J, Matthews, D, Johnstone, H, Boot, C, Cheetham, TD. Copeptin; utility in paediatric patients with hyponatraemia. Horm Res Paediatr 2021;82\u20137. https:\/\/doi.org\/10.1159\/000521073.","DOI":"10.1159\/000521073"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_024","doi-asserted-by":"crossref","unstructured":"Jones, B, Corredor, M, Lteif, A, Pittock, S, Bornhorst, J, Creo, A. Use of copeptin levels to predict the resolution of transient postoperative SIADH. Horm Res Paediatr 2020;93:258\u201362. https:\/\/doi.org\/10.1159\/000509549.","DOI":"10.1159\/000509549"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_025","unstructured":"Mayo Medical Laboratories. Available from: https:\/\/www.mayocliniclabs.com\/test-catalog\/overview\/603599#Clinical-and-Interpretive."},{"key":"2023050204214810376_j_jpem-2022-0525_ref_026","doi-asserted-by":"crossref","unstructured":"de Vries, F, Lobatto, DJ, Verstegen, MJT, van Furth, WR, Pereira, AM, Biermasz, NR. Postoperative diabetes insipidus: how to define and grade this complication? Pituitary 2021;24:284\u201391. https:\/\/doi.org\/10.1007\/s11102-020-01083-7.","DOI":"10.1007\/s11102-020-01083-7"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_027","doi-asserted-by":"crossref","unstructured":"Winzeler, B, Zweifel, C, Nigro, N, Arici, B, Bally, M, Schuetz, P, et al.. Postoperative copeptin concentration predicts diabetes insipidus after pituitary surgery. J Clin Endocrinol Metab 2015;100:2275\u201382. https:\/\/doi.org\/10.1210\/jc.2014-4527.","DOI":"10.1210\/jc.2014-4527"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_028","doi-asserted-by":"crossref","unstructured":"Vanasuntorn, A, Hansasuta, A, Chailurkit, LO, Sriphrapradang, C. Postoperative copeptin as a biomarker for development of diabetes insipidus following hypothalamic-pituitary surgery. Endocr Pract 2021;27:463\u201370. https:\/\/doi.org\/10.1016\/j.eprac.2020.11.015.","DOI":"10.1016\/j.eprac.2020.11.015"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_029","doi-asserted-by":"crossref","unstructured":"Berton, AM, Gatti, F, Penner, F, Varaldo, E, Prencipe, N, Rumbolo, F, et al.. Early copeptin determination allows prompt diagnosis of post-neurosurgical central diabetes insipidus. Neuroendocrinology 2020;110:525\u201334. https:\/\/doi.org\/10.1159\/000503145.","DOI":"10.1159\/000503145"},{"key":"2023050204214810376_j_jpem-2022-0525_ref_030","doi-asserted-by":"crossref","unstructured":"Boal, RL, Hughes, J, Matthews, D, Johnstone, H, Boot, C, Cheetham, TD. Copeptin: utility in paediatric patients with hyponatraemia. Horm Res Paediatr 2022;95:82\u20137. https:\/\/doi.org\/10.1159\/000521073.","DOI":"10.1159\/000521073"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0525\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0525\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T04:23:21Z","timestamp":1683001401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2022-0525\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3,15]]},"published-print":{"date-parts":[[2023,5,25]]}},"alternative-id":["10.1515\/jpem-2022-0525"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2022-0525","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]}}}