{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:39:15Z","timestamp":1792683555692,"version":"4.5.0"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0536_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We sought to evaluate the impact of estrogen-containing treatment for heavy menstrual bleeding (HMB) on subsequent height compared to progesterone-only or non-hormonal treatment when initiated at menarche.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0536_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective chart review of adolescent females aged 10\u201315 years who presented to an institution-affiliated outpatient, inpatient, or emergency setting for management of HMB within three months of menarche. Growth records over a 2 year period starting at menarche were recorded, and comparisons made among patients treated with 1) estrogen, 2) progesterone, and 3) non-hormonal methods (controls). Groups were compared using bivariate analysis with Chi-square or Fisher\u2019s exact test and linear regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0536_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In an analysis of 80 patients at 24\u00a0months, the mean increase in height from menarche was 6.4\u00a0cm among controls (n=54), 7.2\u00a0cm among the progesterone-only group (n=10), and 3.8\u00a0cm among the estrogen group (n=16). The estrogen group\u2019s increase in height was significantly lower than the control group\u2019s, by a mean of 1.8\u00a0cm (p=0.04). Change in height did not differ significantly between the progesterone and control groups (p=0.87). Additionally, for every year younger at menarche, there was 1 fewer cm of growth (change in height) at 24\u00a0months after menarche (p&lt;0.002).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0536_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Estrogen-containing treatment for HMB initiated within three months of menarche was associated with reduced growth at 24\u00a0months compared to progesterone-only or non-hormonal methods. The clinical applicability of the estrogen group\u2019s 1.8\u00a0cm absolute reduction in height may have considerable significance for those who are shorter at baseline.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0536","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:05:47Z","timestamp":1675328747000},"page":"255-260","source":"Crossref","is-referenced-by-count":6,"title":["The relationship between estrogen and subsequent growth restriction among adolescents with heavy menstrual bleeding at menarche"],"prefix":"10.1515","volume":"36","author":[{"given":"Jessie M.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Michigan Medical School , Ann Arbor , MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah D.","family":"Compton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Michigan Medical School , Ann Arbor , MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina M.","family":"Farahzad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Michigan , Ann Arbor , MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia K.","family":"Winfrey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Michigan , Ann Arbor , MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica W.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Michigan , Ann Arbor , MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"2023033123251293548_j_jpem-2022-0536_ref_001","doi-asserted-by":"crossref","unstructured":"Nur Azurah, AG, Sanci, L, Moore, E, Grover, S. 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