{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:45:17Z","timestamp":1764859517625,"version":"3.40.5"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0573_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to evaluate the stiffness of the thyroid parenchyma with Shear wave elastography (SWE) in children with Hashimoto\u2019s thyroiditis (HT) and healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0573_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 130 children with HT and 46 healthy controls were included in this study. The clinical and laboratory characteristics of the groups, thyroiditis stages in thyroid ultrasonography, and SWE scores which was obtained as kilopascal (kPa), were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0573_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed that SWE scores were significantly higher in children with HT compared to healthy controls, and SWE scores increased significantly in HT group, as the thyroiditis stage increased (p&lt;0.001). Median, 1st (Q1) and 3rd (Q3) quartiles of SWE scores were as follows; healthy control: 7.4\u00a0kPa (6\u201310.6), stage 1 HT: 9.6\u00a0kPa (7.4\u201311.2), stage 2 HT: 15.2\u00a0kPa (10.8\u201319.9), stage 3 HT: 17.9\u00a0kPa (13.7\u201325.8), (p&lt;0.001).\u00a0Children with HT were divided into subgroups according to\u00a0serum TSH and free T4 levels as euthyroid (103;\u00a079.2%\u00a0of\u00a0children), euthyroid but subclinical TSH elevation (7; 5.4% of\u00a0children), hypothyroidism (11; 8.5% of children) and hyperthyroidism (9; 6.9% of children). The SWE scores were significantly higher in children with hypothyroidism with HT compared to healthy controls 17.9\u00a0kPa (13.6\u201327.5) vs. 7.4\u00a0kPa (6\u201310.6), and in euthyroid children with HT compared to healthy controls 11.5\u00a0kPa (9.2\u201315.6) vs. 7.4\u00a0kPa (6\u201310.6), (p=0.006 and p&lt;0.001, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0573_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The SWE scores increase as the thyroiditis stage increases in children with HT. There was no significant difference in SWE scores between stage 2 and stage 3 thyroiditis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0573","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T05:20:32Z","timestamp":1677475232000},"source":"Crossref","is-referenced-by-count":1,"title":["Can thyroid elastography with ultrasound be used to stage children with Hashimoto\u2019s thyroiditis?"],"prefix":"10.1515","volume":"0","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-2369","authenticated-orcid":false,"given":"Serkan Bilge","family":"Koca","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology , Health Sciences University, Kayseri City Hospital , Kayseri , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-4058","authenticated-orcid":false,"given":"Turgut","family":"Seber","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Pediatric Radiology , Health Sciences University, Kayseri City Hospital , Kayseri , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"2023022705202445388_j_jpem-2022-0573_ref_001","doi-asserted-by":"crossref","unstructured":"Diaz, A, Lipman Diaz, EG. 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