{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:49:04Z","timestamp":1747198144571,"version":"3.40.5"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0637_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Few studies addressed the efficacy of human insulin regimens (mostly premix insulin) used in many low-and-middle income countries on glycemic control of children and adolescents with diabetes. The aim of this study was to assess the efficacy of the premix insulin on the glycated hemoglobin (HbA<jats:sub>1c<\/jats:sub>) in comparison to the regular with NPH insulin scheme.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0637_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective study was carried out from January 2020 to September 2022 on patients with type 1 diabetes aged below 18\u00a0years followed in Burkina Life For A Child program. They were categorized into three groups, on regular with NPH insulin (Group A), on premix insulin (Group B) and on regular with premix insulin (Group C). Outcome was analyzed based on HbA<jats:sub>1c<\/jats:sub> level.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0637_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixty-eight patients with a mean age of 15.38\u00a0\u00b1\u00a02.26\u00a0years and the sex ratio (M\/W) 0.94 were studied. There were 14 in Group A, 20 in Group B, and 34 patients in Group C. The mean HbA<jats:sub>1c<\/jats:sub> value in the corresponding insulin regimen was 12.8\u00a0\u00b1\u00a01.39%, 9.87\u00a0\u00b1\u00a02.18%, and 10.66\u00a0\u00b1\u00a02.1%, respectively. Glycemic control was better in Groups B and C than Group A (p&lt;0.05) but there was no difference between groups B and C.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0637_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results indicate that the use of premix insulin gives a better glycemic control than NPH insulin. However, further prospective study of these insulin regimens with a strengthening education strategy and glycemic control by continuous glucose monitoring and HbA<jats:sub>1c<\/jats:sub> is required to corroborate these preliminary findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0637","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T17:50:28Z","timestamp":1678729828000},"page":"447-450","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of regular with NPH insulin vs. premix insulin in children and adolescents with type 1 diabetes in a resources-limited setting: a retrospective data analysis"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-2967","authenticated-orcid":false,"given":"Yempabou","family":"Sagna","sequence":"first","affiliation":[{"name":"Service de m\u00e9decine interne , CHU Sour\u00f4 Sanou , Bobo Dioulasso , Burkina Faso"},{"name":"INSSA\u00a0\u2013 Universit\u00e9 Nazi BONI , Bobo Dioulasso , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wend Pagnangde Abraham Hermann","family":"Bagbila","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne , CHU Sour\u00f4 Sanou , Bobo Dioulasso , Burkina Faso"},{"name":"INSSA\u00a0\u2013 Universit\u00e9 Nazi BONI , Bobo Dioulasso , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Bognounou","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne CHU Yalgado Ou\u00e9draogo , Bobo Dioulasso , Burkina Faso"},{"name":"UFR\/SDS\u00a0\u2013 Universit\u00e9 Joseph Ki Zerbo , Ouagadougou , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alassane","family":"Ilboudo","sequence":"additional","affiliation":[{"name":"CHR de Banfora , Banfora , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nongoba","family":"Sawadogo","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHUR de Ouahigouya , Universit\u00e9 de Ouahigouya , Ouahigouya , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole G.","family":"Kyelem","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne , CHU Sour\u00f4 Sanou , Bobo Dioulasso , Burkina Faso"},{"name":"INSSA\u00a0\u2013 Universit\u00e9 Nazi BONI , Bobo Dioulasso , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumar","family":"Guira","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne CHU Yalgado Ou\u00e9draogo , Bobo Dioulasso , Burkina Faso"},{"name":"UFR\/SDS\u00a0\u2013 Universit\u00e9 Joseph Ki Zerbo , Ouagadougou , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macaire S.","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne , CHU Sour\u00f4 Sanou , Bobo Dioulasso , Burkina Faso"},{"name":"INSSA\u00a0\u2013 Universit\u00e9 Nazi BONI , Bobo Dioulasso , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Y.","family":"Drabo","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne CHU Yalgado Ou\u00e9draogo , Bobo Dioulasso , Burkina Faso"},{"name":"UFR\/SDS\u00a0\u2013 Universit\u00e9 Joseph Ki Zerbo , Ouagadougou , Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"2023050204214803081_j_jpem-2022-0637_ref_001","doi-asserted-by":"crossref","unstructured":"Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications Research Group, Lachin, JM, Genuth, S, Cleary, P, Davis, MD, Nathan, DM. 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