{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:59:38Z","timestamp":1781564378841,"version":"3.54.5"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0642_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Activating variants of the <jats:italic>ABCC8<\/jats:italic> gene cause neonatal diabetes or maturity-onset diabetes of the young (MODY). We report three cases of MODY type 12 caused by variants in the <jats:italic>ABCC8<\/jats:italic> encoding sulphonylurea receptor 1, and the experience of switching from insulin therapy to sulphonylurea therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0642_abs_002\">\n                  <jats:title>Case presentations<\/jats:title>\n                  <jats:p>We describe a 12.5-year-old girl with permanent neonatal diabetes mellitus, and two diabetes mellitus cases with variants in the <jats:italic>ABCC8<\/jats:italic> gene. Two of these cases were successfully switched from subcutaneous insulin to oral glibenclamide, with a marked improvement in glycemic control. In permanent neonatal diabetes case, glibenclamide dose was progressively increased to achieve a full dose (2\u202fmg\/kg\/day) in 9\u00a0days. Nine months after starting oral sulphonylurea therapy, her blood glucose control dramatically improved and insulin therapy was discontinued.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0642_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We conclude that patients with <jats:italic>ABCC8<\/jats:italic> gene\u00a0variants can successfully switch from insulin to sulphonylureas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0642","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T20:23:04Z","timestamp":1681849384000},"source":"Crossref","is-referenced-by-count":2,"title":["ABCC8-related maturity-onset diabetes of the young: switching from insulin to sulphonylurea therapy: how long do we need for a good metabolic control?"],"prefix":"10.1515","volume":"0","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7169-890X","authenticated-orcid":false,"given":"Ferda","family":"Evin","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes , Ege University , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-2408","authenticated-orcid":false,"given":"Esra","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Genetics , Ege University , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-8866","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Onay","sequence":"additional","affiliation":[{"name":"Multigen Genetic Diseases Diagnosis Center , Izmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-2713","authenticated-orcid":false,"given":"Samim","family":"\u00d6zen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes , Ege University , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-6397","authenticated-orcid":false,"given":"\u015e\u00fckran","family":"Darcan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes , Ege University , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6108-0591","authenticated-orcid":false,"given":"Damla","family":"G\u00f6k\u015fen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes , Ege University , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"2023041820225633048_j_jpem-2022-0642_ref_001","doi-asserted-by":"crossref","unstructured":"Lachance, CH. 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