{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:22:23Z","timestamp":1772580143082,"version":"3.50.1"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0136_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Hypothalamic hamartoma (HH) typically presents with gonadotrophin-dependent precocious puberty and\/or seizures. Other endocrine disturbances are rare. We describe an infant with syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) and a HH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0136_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 6-week-old infant presented with seizures and life-threatening hyponatremia. A HH was identified on magnetic resonance imaging. Clinical examination and biochemistry were consistent with SIADH, and serum copeptin was high during hyponatremia, further supporting this diagnosis. Tolvaptan was effective in normalizing plasma sodium and enabling liberalization of fluids to ensure sufficient nutritional intake and weight gain and manage hunger.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0136_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Hyponatremia due to SIADH is novel at presentation of a HH, and can be challenging to diagnose and manage. Successful management of hyponatremia in this case was achieved using tolvaptan.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0136","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T17:20:32Z","timestamp":1686936032000},"page":"895-899","source":"Crossref","is-referenced-by-count":1,"title":["Syndrome of inappropriate secretion of anti-diuretic hormone due to hypothalamic hamartoma: use of tolvaptan"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-2284","authenticated-orcid":false,"given":"Rebecca Jane","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology , Southampton Children\u2019s Hospital, University Hospital Southampton NHS Foundation Trust , Southampton , UK"},{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maisara","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Paediatrics , Frimley Park Hospital , Guildford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieke","family":"Hoogenboom","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology , Bristol Royal Hospital for Children , Bristol , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney D.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology , Southampton Children\u2019s Hospital, University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Bird-Lieberman","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology , Southampton Children\u2019s Hospital, University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaspal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology , Southampton Children\u2019s Hospital, University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Bockenhauer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology , Great Ormond Street Hospital , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anitha","family":"Kumaran","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology , Southampton Children\u2019s Hospital, University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"2023090517184941262_j_jpem-2023-0136_ref_001","doi-asserted-by":"crossref","unstructured":"Harrison, VS, Oatman, O, Kerrigan, JF. Hypothalamic hamartoma with epilepsy: review of endocrine comorbidity. Epilepsia 2017;58:50\u20139. https:\/\/doi.org\/10.1111\/epi.13756.","DOI":"10.1111\/epi.13756"},{"key":"2023090517184941262_j_jpem-2023-0136_ref_002","doi-asserted-by":"crossref","unstructured":"Wang, AY, Wong, TT, Hsieh, KL, Tsai, ML, Yang, C. Giant cystic hypothalamic hamartoma in an infant associated with persistent syndrome of inappropriate antidiuretic hormone secretion. Childs Nerv Syst 2022;38:1593\u20137. https:\/\/doi.org\/10.1007\/s00381-021-05439-7.","DOI":"10.1007\/s00381-021-05439-7"},{"key":"2023090517184941262_j_jpem-2023-0136_ref_003","doi-asserted-by":"crossref","unstructured":"Bhandari, SS, Loke, I, Davies, JE, Squire, IB, Struck, J, Ng, LL. Gender and renal function influence plasma levels of copeptin in healthy individuals. 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Clin Neurol Neurosurg 2020;197:106076. https:\/\/doi.org\/10.1016\/j.clineuro.2020.106076.","DOI":"10.1016\/j.clineuro.2020.106076"},{"key":"2023090517184941262_j_jpem-2023-0136_ref_006","doi-asserted-by":"crossref","unstructured":"Culler, FL, James, HE, Simon, ML, Jones, KL. Identification of gonadotropin-releasing hormone in neurons of a hypothalamic hamartoma in a boy with precocious puberty. Neurosurgery 1985;17:408\u201312. https:\/\/doi.org\/10.1097\/00006123-198509000-00003.","DOI":"10.1097\/00006123-198509000-00003"},{"key":"2023090517184941262_j_jpem-2023-0136_ref_007","doi-asserted-by":"crossref","unstructured":"Refardt, J, Winzeler, B, Christ-Crain, M. Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis. 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