{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:42:55Z","timestamp":1793468575498,"version":"4.5.0"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0146_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Compare the efficacy and safety of daily vs. monthly oral vitamin D<jats:sub>3<\/jats:sub> in treating symptomatic vitamin D deficiency in infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0146_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>90 infants with symptomatic vitamin D deficiency were randomized into Daily (D) [46 infants] and Bolus (B) [44 infants] groups to receive oral vitamin D<jats:sub>3<\/jats:sub>, daily (2000 IU\/day) and bolus (60,000 IU\/month) for three months respectively. Both groups received daily oral calcium @50\u202fmg\/kg\/day. Serum calcium (Ca), phosphate (P), alkaline phosphatase (ALP), 25-hydroxy cholecalciferol [25(OH)D], parathyroid hormone (PTH) levels, urine calcium: creatinine ratio and radiological score were assessed at baseline, 4 and 12\u00a0weeks. At the end of 12\u00a0weeks, 78 infants were available for evaluation of efficacy and safety of both regimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0146_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Both regimens led to a statistically significant increase in Ca and P levels and fall in ALP and PTH levels from baseline to 4 and 12\u00a0weeks of therapy, with no inter-group difference. Infants in group D had statistically significant higher mean 25(OH)D levels as compared to group B at 4\u00a0weeks (group D 130.89 \u00b1 43.43\u202fnmol\/L, group B\u00a0\u2013 108.25 \u00b1 32.40\u202fnmol\/L; p\u00a0\u2013 0.012) and 12\u00a0weeks (group D\u00a0\u2013 193.69\u00a0\u00b1\u00a032.47\u202fnmol\/L, group B\u00a0\u2013 153.85 \u00b1 33.60\u202fnmol\/L; p&lt;0.001). Eight infants [group D\u00a0\u2013 6\/41 (14.6\u202f%); group B\u00a0\u2013 2\/37 (5.4\u202f%), p=0.268] developed mild asymptomatic hypercalcemia without hypercalciuria at 12\u00a0weeks that corrected spontaneously within a week.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0146_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both daily and monthly oral vitamin D<jats:sub>3<\/jats:sub> in equivalent doses are efficacious and safe for treating symptomatic vitamin D deficiency in infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0146","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T20:40:30Z","timestamp":1684269630000},"page":"683-691","source":"Crossref","is-referenced-by-count":5,"title":["Daily vs. monthly oral vitamin D<sub>3<\/sub> for treatment of symptomatic vitamin D deficiency in infants: a randomized controlled trial"],"prefix":"10.1515","volume":"36","author":[{"given":"Anupriya","family":"Gora","sequence":"first","affiliation":[{"name":"Lady Hardinge Medical College , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Lady Hardinge Medical College , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Debnath","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Lady Hardinge Medical College , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev Kumar","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Delhi Cancer Registry , BR Ambedkar IRCH, All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-8835","authenticated-orcid":false,"given":"Anju","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Lady Hardinge Medical College , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"2023070813115021786_j_jpem-2023-0146_ref_001","doi-asserted-by":"crossref","unstructured":"Creo, AL, Thacher, TD, Pettifor, JM, Strand, MA, Fischer, PR. Nutritional rickets around the world: an update. Paediatr Int Child Health 2017;37:84\u201398. https:\/\/doi.org\/10.1080\/20469047.2016.1248170.","DOI":"10.1080\/20469047.2016.1248170"},{"key":"2023070813115021786_j_jpem-2023-0146_ref_002","doi-asserted-by":"crossref","unstructured":"Jiang, Z, Pu, R, Li, N, Chen, C, Li, J, Dai, W, et al.. High prevalence of vitamin D deficiency in Asia: a systematic review and meta-analysis. Crit Rev Food Sci Nutri 2021:1\u201310. https:\/\/doi.org\/10.1080\/10408398.2021.1990850.","DOI":"10.1080\/10408398.2021.1990850"},{"key":"2023070813115021786_j_jpem-2023-0146_ref_003","unstructured":"Surve, S, Chauhan, S, Amdekar, Y, Joshi, B. Vitamin D deficiency in children: an update on its prevalence, therapeutics and knowledge gap s. Indian J Nutr 2017;4:167."},{"key":"2023070813115021786_j_jpem-2023-0146_ref_004","doi-asserted-by":"crossref","unstructured":"Mehrotra, P, Marwaha, RK, Aneja, S, Seth, A, Singla, BM, Ashraf, G, et al.. 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